The Role of Atrial Premature Complexes in Exercise Test in Predicting Atrial Fibrillation in Patients Without Obstructive Coronary Artery Disease
Background Atrial fibrillation (AF) is usually triggered by frequent atrial premature complexes (APC) and atrial tachycardias originated in the pulmonary veins. The aim of the current study is to clarify the relationship between AF and APCs observed during treadmill exercise testing through long‐ter...
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| Veröffentlicht in: | Pacing and clinical electrophysiology 2024-12, Vol.47 (12), p.1586-1592 |
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| creator | Tezen, Ozan Pay, Levent Yumurtaş, Ahmet Çağdaş Çetin, Tuğba Eren, Semih Öz, Melih Coşkun, Cahit Karabacak, Cemre Yenitürk, Birkan Çınar, Tufan Hayıroğlu, Mert İlker |
| description | Background
Atrial fibrillation (AF) is usually triggered by frequent atrial premature complexes (APC) and atrial tachycardias originated in the pulmonary veins. The aim of the current study is to clarify the relationship between AF and APCs observed during treadmill exercise testing through long‐term patient follow‐up.
Material and Methods
Our study only examined the data of patients who did not have any obstructive coronary artery disease and had an exercise test. In total, 1559 patients were included in this research. The study data were divided into two groups according to the development of AF during follow‐up. The patients who developed any type of AF during the follow‐up period were classified as AF (+). Mean follow‐up time for AF (+) and (−) groups were 48 and 47 months, respectively.
Results
In the univariable analysis, age, LAAP, and the presence of APCs (HR: 3.906, 95% CI: 2.848–5.365, p < 0.001) during the treadmill exercise test were significantly associated with the development of AF. In the multivariable analysis, age (adjusted HR: 1.063, 95% CI: 1.043–1.083, p < 0.001) and the presence of APCs during the treadmill exercise test (adjusted HR: 2.504, 95% CI: 1.759–3.565, p < 0.001) emerged as independent risk factors for the development of AF. The AF‐free survival was significantly lower in the APCs (+) patients compared with the APCs (−) patients (log rank p < 0.001).
Conclusion
Our study revealed that individuals without obstructive CAD who exhibited frequent APCs during treadmill exercise tests were more likely to develop AF. |
| doi_str_mv | 10.1111/pace.15090 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3116339381</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3116339381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2460-528204be34c2ce047cc5ef6e8487685aa4cefe28972bf9eb9a633beb77ded4d03</originalsourceid><addsrcrecordid>eNp9kcFO3DAQhq2qiF0olz5AZakXhBSwYydxjqtlaSshgapFHCPHmXSNknixHQqP0TfuLLvLgQO-jDX65tOMfkK-cnbO8V2stYFznrGSfSJTnkmWKJ6Vn8mUcVkkSqhyQo5CeGCM5Uxmh2QiSsmYKOSU_FuugP52HVDX0ln0Vnf01kOv4-iBzl2_7uAZArUDXTyDNzYAXUKImwZyjTXRDn_2k1e29rbrdLRueCXwB0MM9N7GlRsjvalD9CPOPG3k3g3av9CZj4DlEt06wBdy0OouwMmuHpO7q8Vy_jO5vvnxaz67Tkwqc5ZkqUqZrEFIkxpgsjAmgzYHJVWRq0xraaCFVJVFWrcl1KXOhaihLooGGtkwcUxOt961d48jnlT1NhjA7QdwY6gE5zhRCsUR_f4OfXCjH3A7pGSKWJoVSJ1tKeNdCB7aau1tjwdWnFWboKpNUNVrUAh_2ynHuofmDd0ngwDfAn9tBy8fqKrb2Xyxlf4HjRGfeg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3142633257</pqid></control><display><type>article</type><title>The Role of Atrial Premature Complexes in Exercise Test in Predicting Atrial Fibrillation in Patients Without Obstructive Coronary Artery Disease</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Tezen, Ozan ; Pay, Levent ; Yumurtaş, Ahmet Çağdaş ; Çetin, Tuğba ; Eren, Semih ; Öz, Melih ; Coşkun, Cahit ; Karabacak, Cemre ; Yenitürk, Birkan ; Çınar, Tufan ; Hayıroğlu, Mert İlker</creator><creatorcontrib>Tezen, Ozan ; Pay, Levent ; Yumurtaş, Ahmet Çağdaş ; Çetin, Tuğba ; Eren, Semih ; Öz, Melih ; Coşkun, Cahit ; Karabacak, Cemre ; Yenitürk, Birkan ; Çınar, Tufan ; Hayıroğlu, Mert İlker</creatorcontrib><description>Background
Atrial fibrillation (AF) is usually triggered by frequent atrial premature complexes (APC) and atrial tachycardias originated in the pulmonary veins. The aim of the current study is to clarify the relationship between AF and APCs observed during treadmill exercise testing through long‐term patient follow‐up.
Material and Methods
Our study only examined the data of patients who did not have any obstructive coronary artery disease and had an exercise test. In total, 1559 patients were included in this research. The study data were divided into two groups according to the development of AF during follow‐up. The patients who developed any type of AF during the follow‐up period were classified as AF (+). Mean follow‐up time for AF (+) and (−) groups were 48 and 47 months, respectively.
Results
In the univariable analysis, age, LAAP, and the presence of APCs (HR: 3.906, 95% CI: 2.848–5.365, p < 0.001) during the treadmill exercise test were significantly associated with the development of AF. In the multivariable analysis, age (adjusted HR: 1.063, 95% CI: 1.043–1.083, p < 0.001) and the presence of APCs during the treadmill exercise test (adjusted HR: 2.504, 95% CI: 1.759–3.565, p < 0.001) emerged as independent risk factors for the development of AF. The AF‐free survival was significantly lower in the APCs (+) patients compared with the APCs (−) patients (log rank p < 0.001).
Conclusion
Our study revealed that individuals without obstructive CAD who exhibited frequent APCs during treadmill exercise tests were more likely to develop AF.</description><identifier>ISSN: 0147-8389</identifier><identifier>ISSN: 1540-8159</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/pace.15090</identifier><identifier>PMID: 39400374</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aged ; atrial fibrillation ; Atrial Fibrillation - physiopathology ; atrial premature complexes ; Atrial Premature Complexes - complications ; Atrial Premature Complexes - physiopathology ; Cardiac arrhythmia ; Cardiovascular disease ; Coronary artery disease ; Coronary Artery Disease - complications ; Coronary Artery Disease - physiopathology ; Coronary vessels ; Exercise Test ; Female ; Fibrillation ; Fitness equipment ; Heart diseases ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk Factors ; Vein & artery diseases</subject><ispartof>Pacing and clinical electrophysiology, 2024-12, Vol.47 (12), p.1586-1592</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2460-528204be34c2ce047cc5ef6e8487685aa4cefe28972bf9eb9a633beb77ded4d03</cites><orcidid>0000-0002-7311-2826 ; 0000-0002-7491-8119 ; 0000-0002-2774-8348</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpace.15090$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpace.15090$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39400374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tezen, Ozan</creatorcontrib><creatorcontrib>Pay, Levent</creatorcontrib><creatorcontrib>Yumurtaş, Ahmet Çağdaş</creatorcontrib><creatorcontrib>Çetin, Tuğba</creatorcontrib><creatorcontrib>Eren, Semih</creatorcontrib><creatorcontrib>Öz, Melih</creatorcontrib><creatorcontrib>Coşkun, Cahit</creatorcontrib><creatorcontrib>Karabacak, Cemre</creatorcontrib><creatorcontrib>Yenitürk, Birkan</creatorcontrib><creatorcontrib>Çınar, Tufan</creatorcontrib><creatorcontrib>Hayıroğlu, Mert İlker</creatorcontrib><title>The Role of Atrial Premature Complexes in Exercise Test in Predicting Atrial Fibrillation in Patients Without Obstructive Coronary Artery Disease</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing Clin Electrophysiol</addtitle><description>Background
Atrial fibrillation (AF) is usually triggered by frequent atrial premature complexes (APC) and atrial tachycardias originated in the pulmonary veins. The aim of the current study is to clarify the relationship between AF and APCs observed during treadmill exercise testing through long‐term patient follow‐up.
Material and Methods
Our study only examined the data of patients who did not have any obstructive coronary artery disease and had an exercise test. In total, 1559 patients were included in this research. The study data were divided into two groups according to the development of AF during follow‐up. The patients who developed any type of AF during the follow‐up period were classified as AF (+). Mean follow‐up time for AF (+) and (−) groups were 48 and 47 months, respectively.
Results
In the univariable analysis, age, LAAP, and the presence of APCs (HR: 3.906, 95% CI: 2.848–5.365, p < 0.001) during the treadmill exercise test were significantly associated with the development of AF. In the multivariable analysis, age (adjusted HR: 1.063, 95% CI: 1.043–1.083, p < 0.001) and the presence of APCs during the treadmill exercise test (adjusted HR: 2.504, 95% CI: 1.759–3.565, p < 0.001) emerged as independent risk factors for the development of AF. The AF‐free survival was significantly lower in the APCs (+) patients compared with the APCs (−) patients (log rank p < 0.001).
Conclusion
Our study revealed that individuals without obstructive CAD who exhibited frequent APCs during treadmill exercise tests were more likely to develop AF.</description><subject>Aged</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>atrial premature complexes</subject><subject>Atrial Premature Complexes - complications</subject><subject>Atrial Premature Complexes - physiopathology</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary vessels</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fibrillation</subject><subject>Fitness equipment</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Vein & artery diseases</subject><issn>0147-8389</issn><issn>1540-8159</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFO3DAQhq2qiF0olz5AZakXhBSwYydxjqtlaSshgapFHCPHmXSNknixHQqP0TfuLLvLgQO-jDX65tOMfkK-cnbO8V2stYFznrGSfSJTnkmWKJ6Vn8mUcVkkSqhyQo5CeGCM5Uxmh2QiSsmYKOSU_FuugP52HVDX0ln0Vnf01kOv4-iBzl2_7uAZArUDXTyDNzYAXUKImwZyjTXRDn_2k1e29rbrdLRueCXwB0MM9N7GlRsjvalD9CPOPG3k3g3av9CZj4DlEt06wBdy0OouwMmuHpO7q8Vy_jO5vvnxaz67Tkwqc5ZkqUqZrEFIkxpgsjAmgzYHJVWRq0xraaCFVJVFWrcl1KXOhaihLooGGtkwcUxOt961d48jnlT1NhjA7QdwY6gE5zhRCsUR_f4OfXCjH3A7pGSKWJoVSJ1tKeNdCB7aau1tjwdWnFWboKpNUNVrUAh_2ynHuofmDd0ngwDfAn9tBy8fqKrb2Xyxlf4HjRGfeg</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Tezen, Ozan</creator><creator>Pay, Levent</creator><creator>Yumurtaş, Ahmet Çağdaş</creator><creator>Çetin, Tuğba</creator><creator>Eren, Semih</creator><creator>Öz, Melih</creator><creator>Coşkun, Cahit</creator><creator>Karabacak, Cemre</creator><creator>Yenitürk, Birkan</creator><creator>Çınar, Tufan</creator><creator>Hayıroğlu, Mert İlker</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7311-2826</orcidid><orcidid>https://orcid.org/0000-0002-7491-8119</orcidid><orcidid>https://orcid.org/0000-0002-2774-8348</orcidid></search><sort><creationdate>202412</creationdate><title>The Role of Atrial Premature Complexes in Exercise Test in Predicting Atrial Fibrillation in Patients Without Obstructive Coronary Artery Disease</title><author>Tezen, Ozan ; Pay, Levent ; Yumurtaş, Ahmet Çağdaş ; Çetin, Tuğba ; Eren, Semih ; Öz, Melih ; Coşkun, Cahit ; Karabacak, Cemre ; Yenitürk, Birkan ; Çınar, Tufan ; Hayıroğlu, Mert İlker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2460-528204be34c2ce047cc5ef6e8487685aa4cefe28972bf9eb9a633beb77ded4d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>atrial premature complexes</topic><topic>Atrial Premature Complexes - complications</topic><topic>Atrial Premature Complexes - physiopathology</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary vessels</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fibrillation</topic><topic>Fitness equipment</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tezen, Ozan</creatorcontrib><creatorcontrib>Pay, Levent</creatorcontrib><creatorcontrib>Yumurtaş, Ahmet Çağdaş</creatorcontrib><creatorcontrib>Çetin, Tuğba</creatorcontrib><creatorcontrib>Eren, Semih</creatorcontrib><creatorcontrib>Öz, Melih</creatorcontrib><creatorcontrib>Coşkun, Cahit</creatorcontrib><creatorcontrib>Karabacak, Cemre</creatorcontrib><creatorcontrib>Yenitürk, Birkan</creatorcontrib><creatorcontrib>Çınar, Tufan</creatorcontrib><creatorcontrib>Hayıroğlu, Mert İlker</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tezen, Ozan</au><au>Pay, Levent</au><au>Yumurtaş, Ahmet Çağdaş</au><au>Çetin, Tuğba</au><au>Eren, Semih</au><au>Öz, Melih</au><au>Coşkun, Cahit</au><au>Karabacak, Cemre</au><au>Yenitürk, Birkan</au><au>Çınar, Tufan</au><au>Hayıroğlu, Mert İlker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Atrial Premature Complexes in Exercise Test in Predicting Atrial Fibrillation in Patients Without Obstructive Coronary Artery Disease</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing Clin Electrophysiol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>47</volume><issue>12</issue><spage>1586</spage><epage>1592</epage><pages>1586-1592</pages><issn>0147-8389</issn><issn>1540-8159</issn><eissn>1540-8159</eissn><abstract>Background
Atrial fibrillation (AF) is usually triggered by frequent atrial premature complexes (APC) and atrial tachycardias originated in the pulmonary veins. The aim of the current study is to clarify the relationship between AF and APCs observed during treadmill exercise testing through long‐term patient follow‐up.
Material and Methods
Our study only examined the data of patients who did not have any obstructive coronary artery disease and had an exercise test. In total, 1559 patients were included in this research. The study data were divided into two groups according to the development of AF during follow‐up. The patients who developed any type of AF during the follow‐up period were classified as AF (+). Mean follow‐up time for AF (+) and (−) groups were 48 and 47 months, respectively.
Results
In the univariable analysis, age, LAAP, and the presence of APCs (HR: 3.906, 95% CI: 2.848–5.365, p < 0.001) during the treadmill exercise test were significantly associated with the development of AF. In the multivariable analysis, age (adjusted HR: 1.063, 95% CI: 1.043–1.083, p < 0.001) and the presence of APCs during the treadmill exercise test (adjusted HR: 2.504, 95% CI: 1.759–3.565, p < 0.001) emerged as independent risk factors for the development of AF. The AF‐free survival was significantly lower in the APCs (+) patients compared with the APCs (−) patients (log rank p < 0.001).
Conclusion
Our study revealed that individuals without obstructive CAD who exhibited frequent APCs during treadmill exercise tests were more likely to develop AF.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39400374</pmid><doi>10.1111/pace.15090</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7311-2826</orcidid><orcidid>https://orcid.org/0000-0002-7491-8119</orcidid><orcidid>https://orcid.org/0000-0002-2774-8348</orcidid></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Aged atrial fibrillation Atrial Fibrillation - physiopathology atrial premature complexes Atrial Premature Complexes - complications Atrial Premature Complexes - physiopathology Cardiac arrhythmia Cardiovascular disease Coronary artery disease Coronary Artery Disease - complications Coronary Artery Disease - physiopathology Coronary vessels Exercise Test Female Fibrillation Fitness equipment Heart diseases Humans Male Middle Aged Predictive Value of Tests Retrospective Studies Risk Factors Vein & artery diseases |
| title | The Role of Atrial Premature Complexes in Exercise Test in Predicting Atrial Fibrillation in Patients Without Obstructive Coronary Artery Disease |
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