$Improving the diffraction quality of heat‐shock protein 47 crystals$

Improving the diffraction quality of heat‐shock protein 47 crystals

Heat‐shock protein 47 (HSP47) is a potential target for inhibitors that ameliorate fibrosis by reducing collagen assembly. In an effort to develop a structure‐based drug‐design system, it was not possible to replicate a previous literature result (PDB entry 4au4) for apo dog HSP47; instead, crystal...

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Veröffentlicht in:	Acta crystallographica. Section F, Structural biology communications Structural biology communications, 2024-11, Vol.80 (11), p.302-313
Hauptverfasser:	Kish, Kevin, Cobell, Stephen, Szapiel, Nicolas, Yan, Chunhong, Newitt, John A., Tredup, Jeffrey, Rodrigo, Iyoncy, Tomasco, Elizabeth, Gao, Mian, Marsilio, Frank, Haugner, John, Lipovšek, Dasa, Deng, Bi, Bousquet, Patrick, Zhang, Yihong, Schmidt, Holly, Sheriff, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asymmetry Crystallization crystallization chaperones Crystallography, X-Ray - methods Crystals C‐ and N‐terminal His‐tags Diffraction Dogs Drug development Escherichia coli - genetics Escherichia coli - metabolism Fibronectin Fibronectins - chemistry Fibronectins - metabolism Fibrosis Gene Expression Heat shock proteins HSP47 HSP47 Heat-Shock Proteins - chemistry HSP47 Heat-Shock Proteins - genetics HSP47 Heat-Shock Proteins - metabolism Humans Models, Molecular Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism
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