Glutathione‐Depleted Photodynamic Nanoadjuvant for Triggering Nonferrous Ferroptosis to Amplify Radiotherapy of Breast Cancer

Radiotherapy plays a crucial role in the treatment of advanced breast cancer, but the increased antioxidant system, especially the rise in glutathione (GSH), presents a significant obstacle to its effectiveness. To address this challenge, a versatile GSH‐depleted photodynamic nanoadjuvant is develop...

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Veröffentlicht in:	Advanced healthcare materials 2024-12, Vol.13 (31), p.e2402474-n/a
Hauptverfasser:	Shi, Jiangnan, Cui, Guoqing, Jin, Yaqi, Mi, Boyu, Liu, Kenan, Zhao, Linqian, Bao, Kewang, Lu, Ziyao, Liu, Jie, Wang, Yuwei, He, Hui, Guo, Zhengqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor activity Biocompatibility Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Cancer therapies Cell Line, Tumor Depletion Effectiveness Female Ferroptosis Ferroptosis - drug effects Glutathione Glutathione - metabolism glutathione depletion Glutathione peroxidase Humans Lipids Mice Mice, Inbred BALB C Nanoparticles - chemistry Oxidation Peroxidase Peroxides Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Photochemotherapy - methods photodynamic therapy photosensitizer Radiation therapy radiotherapy Tumor microenvironment Tumor Microenvironment - drug effects
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