Captopril inhibits the overproduction of proopiomelanocortin and adrenocorticotropic hormone in the pituitary gland of male diabetic mice in close relationship with an increase in glucocorticoid receptor expression

Prior investigation shows that diabetic patients present hypothalamus-pituitary-adrenal (HPA) axis hyperactivity related to impaired negative feedback. This study investigates the effect of Captopril on the overproduction of adrenocorticotropic hormone (ACTH) and its precursor proopiomelanocortin (P...

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Veröffentlicht in:	European journal of pharmacology 2024-12, Vol.984, p.177057, Article 177057
Hauptverfasser:	Chaves, Amanda da Silva, Magalhães, Nathalia Santos, Insuela, Daniella Bianchi Reis, Silva, Patrícia Machado Rodrigues e, Martins, Marco Aurélio, Carvalho, Vinicius Frias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Angiotensin II1 Animals bcl-2-Associated X Protein - metabolism Captopril Captopril - pharmacology Corticosterone - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism diabetes2 Glucocorticoid receptor3 HPA axis4 Ki-67 Antigen - metabolism Male Mice Pituitary Gland - drug effects Pituitary Gland - metabolism POMC5 Pro-Opiomelanocortin - genetics Pro-Opiomelanocortin - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Receptor, Angiotensin, Type 1 - metabolism Receptor, Angiotensin, Type 2 - metabolism Receptors, Glucocorticoid - metabolism
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