Loss of TET Activity in the Postnatal Mouse Brain Perturbs Synaptic Gene Expression and Impairs Cognitive Function

Conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) by ten-eleven translocation (TET) family proteins leads to the accumulation of 5hmC in the central nervous system; however, the role of 5hmC in the postnatal brain and how its levels and target genes are regulated by TETs remain...

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Veröffentlicht in:	Neuroscience bulletin 2024-11, Vol.40 (11), p.1699-1712
Hauptverfasser:	Liu, Ji-Wei, Zhang, Ze-Qiang, Zhu, Zhi-Chuan, Li, Kui, Xu, Qiwu, Zhang, Jing, Cheng, Xue-Wen, Li, Han, Sun, Ying, Wang, Ji-Jun, Hu, Lu-Lu, Xiong, Zhi-Qi, Zhu, Yongchuan
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives 5-Methylcytosine - metabolism Anatomy Anesthesiology Animals Biomedical and Life Sciences Biomedicine Brain - growth & development Brain - metabolism Cognition - physiology Dioxygenases - genetics Dioxygenases - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic Gene Expression Human Physiology Mice Mice, Inbred C57BL Mice, Knockout Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Neurology Neurosciences Original Article Pain Medicine Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Synapses - genetics Synapses - metabolism
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