Enhancement of protective efficacy of recombinant attenuated Salmonella typhimurium delivering H9N2 avian influenza virus hemagglutinins(HA) antigen vaccine candidate strains by C-C motif chemokine ligand 5 in chickens(chCCL5)

The H9N2 inactivated avian influenza vaccine cannot induce cellular and mucosal immune responses, while the attenuated Salmonella vector as an intracellular bacterium can induce dominant cellular and mucosal immune responses. However, it provides low protection against the virus when delivering vira...

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Veröffentlicht in:	Veterinary microbiology 2024-11, Vol.298, p.110264, Article 110264
Hauptverfasser:	Ma, Jingwen, Xu, Shunshun, Li, Zewei, Li, Yu-An, Wang, Shifeng, Shi, Huoying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antigens arabinose avian influenza bacteria ChCCL5 Chemokine CCL5 - genetics Chemokine CCL5 - immunology chemokines chemotaxis Chickens H9N2 avian influenza virus HA protein HEK293 Cells Hemagglutinin Glycoproteins, Influenza Virus - genetics Hemagglutinin Glycoproteins, Influenza Virus - immunology hemagglutinins Humans Immunity Influenza A virus Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Influenza in Birds - immunology Influenza in Birds - prevention & control Influenza in Birds - virology influenza vaccines Influenza Vaccines - immunology ligands mucosal immunity Poultry Diseases - microbiology Poultry Diseases - prevention & control Poultry Diseases - virology protective effect Recombinant attenuated Salmonella vector Salmonella Typhimurium Salmonella typhimurium - genetics Salmonella typhimurium - immunology Vaccines, Attenuated - immunology Vaccines, Synthetic - immunology viruses
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