Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Acute myeloid leukemia (AML) patients with the FMS-related receptor tyrosine kinase 3 internal tandem duplication (FLT3/ITD) mutation have a poorer prognosis, and treatment with FLT3 tyrosine kinase inhibitors (TKIs) has been hindered by resistance mechanisms. One such mechanism is known as adaptive...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular oncology 2024-10
Hauptverfasser:	Seale, Tessa S, Li, Li, Bruner, J Kyle, Chou, Melody, Nguyen, Bao, Seo, Jaesung, Zhu, Ruiqi, Levis, Mark J, Pratilas, Christine A, Small, Donald
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!