Pseudophakic cystoid macular oedema and posterior capsular opacification rates after combined phaco‐trabeculectomy vs. phaco alone
Purpose To assess the risk for pseudophakic cystoid macular oedema (PCME) and posterior capsular opacification (PCO) associated with combined cataract surgery and trabeculectomy compared to cataract surgery alone. Methods Data analysis of subjects who underwent routine cataract surgery without and w...
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Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2025-02, Vol.103 (1), p.115-120 |
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creator | Levinger, Eliya Ostrovsky, Michael Friehmann, Asaf Elhaddad, Omar Tole, Derek Darcy, Kieren Leadbetter, Duncan Tuuminen, Raimo Goldberg, Mordechai Achiron, Asaf |
description | Purpose
To assess the risk for pseudophakic cystoid macular oedema (PCME) and posterior capsular opacification (PCO) associated with combined cataract surgery and trabeculectomy compared to cataract surgery alone.
Methods
Data analysis of subjects who underwent routine cataract surgery without and with concomitant trabeculectomy at the Department of Ophthalmology, Bristol Eye Hospital, the UK, between January 2008 and December 2017. Odds ratios (ORs) for PCME between the types of surgeries were calculated using univariate and multivariate regression analysis. Multivariate Cox regression controlling for age and gender was used to estimate the hazard ratio (HR) for neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser capsulotomies.
Results
This study included 56 973 cataract surgeries without and 288 with concomitant trabeculectomy (phaco‐trab) with a mean follow‐up time of 6.9 ± 4.2 years. Baseline variables (age and gender, diabetes, pseudoexfoliation, use of pupil expansion device and postoperative follow‐up time) were comparable between the groups. Postoperative rates of PCME remained non‐significant between the cataract surgery and phaco‐trabe groups both in uni‐ and multi‐variate analysis (OR 0.347, 95%CI 0.049–2.477, p = 0.291). Furthermore, in Cox regression analysis adjusted for the patients' age and gender, Nd:YAG laser capsulotomy rates remained non‐significant between the cataract surgery and phaco‐trabe groups (HR 1.250, 95%CI 0.883–1.769, p = 0.209).
Conclusions
In our large cohort study, combining trabeculectomy with cataract surgery did not predispose to an increased PCME or Nd:YAG laser capsulotomy rates. |
doi_str_mv | 10.1111/aos.16766 |
format | Article |
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To assess the risk for pseudophakic cystoid macular oedema (PCME) and posterior capsular opacification (PCO) associated with combined cataract surgery and trabeculectomy compared to cataract surgery alone.
Methods
Data analysis of subjects who underwent routine cataract surgery without and with concomitant trabeculectomy at the Department of Ophthalmology, Bristol Eye Hospital, the UK, between January 2008 and December 2017. Odds ratios (ORs) for PCME between the types of surgeries were calculated using univariate and multivariate regression analysis. Multivariate Cox regression controlling for age and gender was used to estimate the hazard ratio (HR) for neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser capsulotomies.
Results
This study included 56 973 cataract surgeries without and 288 with concomitant trabeculectomy (phaco‐trab) with a mean follow‐up time of 6.9 ± 4.2 years. Baseline variables (age and gender, diabetes, pseudoexfoliation, use of pupil expansion device and postoperative follow‐up time) were comparable between the groups. Postoperative rates of PCME remained non‐significant between the cataract surgery and phaco‐trabe groups both in uni‐ and multi‐variate analysis (OR 0.347, 95%CI 0.049–2.477, p = 0.291). Furthermore, in Cox regression analysis adjusted for the patients' age and gender, Nd:YAG laser capsulotomy rates remained non‐significant between the cataract surgery and phaco‐trabe groups (HR 1.250, 95%CI 0.883–1.769, p = 0.209).
Conclusions
In our large cohort study, combining trabeculectomy with cataract surgery did not predispose to an increased PCME or Nd:YAG laser capsulotomy rates.</description><identifier>ISSN: 1755-375X</identifier><identifier>ISSN: 1755-3768</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.16766</identifier><identifier>PMID: 39394695</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aluminum ; Capsule Opacification - diagnosis ; Capsule Opacification - epidemiology ; Capsule Opacification - etiology ; Capsule Opacification - surgery ; cataract surgery ; Cataracts ; Diabetes mellitus ; Edema ; Eye surgery ; Female ; Follow-Up Studies ; Gender ; Humans ; Incidence ; Lasers ; Macular Edema - diagnosis ; Macular Edema - etiology ; Macular Edema - surgery ; Male ; Middle Aged ; Original ; Phacoemulsification - adverse effects ; Phacoemulsification - methods ; posterior capsular opacification ; Postoperative Complications - epidemiology ; Pseudophakia - complications ; pseudophakic cystoid macular oedema ; Regression analysis ; Retrospective Studies ; Risk Factors ; Surgery ; trabeculectomy ; Trabeculectomy - methods ; Visual Acuity ; Yttrium</subject><ispartof>Acta ophthalmologica (Oxford, England), 2025-02, Vol.103 (1), p.115-120</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.</rights><rights>2024 The Author(s). Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3346-c99c1c6d91d0a906f41a0534836a0b0343c0f3baf77dbe231473d4a616fe78c03</cites><orcidid>0000-0002-6325-7175 ; 0000-0003-1550-8125 ; 0000-0001-7128-3288 ; 0000-0001-6315-6908</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.16766$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.16766$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39394695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levinger, Eliya</creatorcontrib><creatorcontrib>Ostrovsky, Michael</creatorcontrib><creatorcontrib>Friehmann, Asaf</creatorcontrib><creatorcontrib>Elhaddad, Omar</creatorcontrib><creatorcontrib>Tole, Derek</creatorcontrib><creatorcontrib>Darcy, Kieren</creatorcontrib><creatorcontrib>Leadbetter, Duncan</creatorcontrib><creatorcontrib>Tuuminen, Raimo</creatorcontrib><creatorcontrib>Goldberg, Mordechai</creatorcontrib><creatorcontrib>Achiron, Asaf</creatorcontrib><title>Pseudophakic cystoid macular oedema and posterior capsular opacification rates after combined phaco‐trabeculectomy vs. phaco alone</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To assess the risk for pseudophakic cystoid macular oedema (PCME) and posterior capsular opacification (PCO) associated with combined cataract surgery and trabeculectomy compared to cataract surgery alone.
Methods
Data analysis of subjects who underwent routine cataract surgery without and with concomitant trabeculectomy at the Department of Ophthalmology, Bristol Eye Hospital, the UK, between January 2008 and December 2017. Odds ratios (ORs) for PCME between the types of surgeries were calculated using univariate and multivariate regression analysis. Multivariate Cox regression controlling for age and gender was used to estimate the hazard ratio (HR) for neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser capsulotomies.
Results
This study included 56 973 cataract surgeries without and 288 with concomitant trabeculectomy (phaco‐trab) with a mean follow‐up time of 6.9 ± 4.2 years. Baseline variables (age and gender, diabetes, pseudoexfoliation, use of pupil expansion device and postoperative follow‐up time) were comparable between the groups. Postoperative rates of PCME remained non‐significant between the cataract surgery and phaco‐trabe groups both in uni‐ and multi‐variate analysis (OR 0.347, 95%CI 0.049–2.477, p = 0.291). Furthermore, in Cox regression analysis adjusted for the patients' age and gender, Nd:YAG laser capsulotomy rates remained non‐significant between the cataract surgery and phaco‐trabe groups (HR 1.250, 95%CI 0.883–1.769, p = 0.209).
Conclusions
In our large cohort study, combining trabeculectomy with cataract surgery did not predispose to an increased PCME or Nd:YAG laser capsulotomy rates.</description><subject>Aged</subject><subject>Aluminum</subject><subject>Capsule Opacification - diagnosis</subject><subject>Capsule Opacification - epidemiology</subject><subject>Capsule Opacification - etiology</subject><subject>Capsule Opacification - surgery</subject><subject>cataract surgery</subject><subject>Cataracts</subject><subject>Diabetes mellitus</subject><subject>Edema</subject><subject>Eye surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gender</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lasers</subject><subject>Macular Edema - diagnosis</subject><subject>Macular Edema - etiology</subject><subject>Macular Edema - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Phacoemulsification - adverse effects</subject><subject>Phacoemulsification - methods</subject><subject>posterior capsular opacification</subject><subject>Postoperative Complications - epidemiology</subject><subject>Pseudophakia - complications</subject><subject>pseudophakic cystoid macular oedema</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>trabeculectomy</subject><subject>Trabeculectomy - methods</subject><subject>Visual Acuity</subject><subject>Yttrium</subject><issn>1755-375X</issn><issn>1755-3768</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kcFqFTEUhoMotlYXvoAE3NTFvU0mmcxkJaVYLRQqqOAunEnOeFNnJmMyU7m7LvoAfUafxNSpFxXMJoH_y8c5_IQ852zN8zmCkNZcVUo9IPu8KsuVqFT9cPcuP--RJyldMqa4UvIx2RNaaKl0uU9u3iecXRg38NVbardpCt7RHuzcQaQBHfZAYXB0DGnC6EOkFsa0pCNY33oLkw8DjTBhotBmitrQN37A_GsDNvy4vp0iNJidaKfQb-lVWi8RhS4M-JQ8aqFL-Oz-PiCfTt98PHm3Or94e3ZyfL6yQki1slpbbpXT3DHQTLWSAyuFrIUC1jAhhWWtaKCtKtdgIbishJOQl26xqi0TB-T14h3npkdncchzdWaMvoe4NQG8-TsZ_MZ8CVeG84rJWupsOLw3xPBtxjSZ3ieLXQcDhjkZwXmpVa10kdGX_6CXYY5D3i9TZcEKzQuZqVcLZWNIKWK7m4Yzc1euyeWaX-Vm9sWf4-_I321m4GgBvvsOt_83meOLD4vyJ_bdssI</recordid><startdate>202502</startdate><enddate>202502</enddate><creator>Levinger, Eliya</creator><creator>Ostrovsky, Michael</creator><creator>Friehmann, Asaf</creator><creator>Elhaddad, Omar</creator><creator>Tole, Derek</creator><creator>Darcy, Kieren</creator><creator>Leadbetter, Duncan</creator><creator>Tuuminen, Raimo</creator><creator>Goldberg, Mordechai</creator><creator>Achiron, Asaf</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6325-7175</orcidid><orcidid>https://orcid.org/0000-0003-1550-8125</orcidid><orcidid>https://orcid.org/0000-0001-7128-3288</orcidid><orcidid>https://orcid.org/0000-0001-6315-6908</orcidid></search><sort><creationdate>202502</creationdate><title>Pseudophakic cystoid macular oedema and posterior capsular opacification rates after combined phaco‐trabeculectomy vs. phaco alone</title><author>Levinger, Eliya ; Ostrovsky, Michael ; Friehmann, Asaf ; Elhaddad, Omar ; Tole, Derek ; Darcy, Kieren ; Leadbetter, Duncan ; Tuuminen, Raimo ; Goldberg, Mordechai ; Achiron, Asaf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3346-c99c1c6d91d0a906f41a0534836a0b0343c0f3baf77dbe231473d4a616fe78c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Aged</topic><topic>Aluminum</topic><topic>Capsule Opacification - diagnosis</topic><topic>Capsule Opacification - epidemiology</topic><topic>Capsule Opacification - etiology</topic><topic>Capsule Opacification - surgery</topic><topic>cataract surgery</topic><topic>Cataracts</topic><topic>Diabetes mellitus</topic><topic>Edema</topic><topic>Eye surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gender</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lasers</topic><topic>Macular Edema - diagnosis</topic><topic>Macular Edema - etiology</topic><topic>Macular Edema - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Phacoemulsification - adverse effects</topic><topic>Phacoemulsification - methods</topic><topic>posterior capsular opacification</topic><topic>Postoperative Complications - epidemiology</topic><topic>Pseudophakia - complications</topic><topic>pseudophakic cystoid macular oedema</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>trabeculectomy</topic><topic>Trabeculectomy - methods</topic><topic>Visual Acuity</topic><topic>Yttrium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levinger, Eliya</creatorcontrib><creatorcontrib>Ostrovsky, Michael</creatorcontrib><creatorcontrib>Friehmann, Asaf</creatorcontrib><creatorcontrib>Elhaddad, Omar</creatorcontrib><creatorcontrib>Tole, Derek</creatorcontrib><creatorcontrib>Darcy, Kieren</creatorcontrib><creatorcontrib>Leadbetter, Duncan</creatorcontrib><creatorcontrib>Tuuminen, Raimo</creatorcontrib><creatorcontrib>Goldberg, Mordechai</creatorcontrib><creatorcontrib>Achiron, Asaf</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levinger, Eliya</au><au>Ostrovsky, Michael</au><au>Friehmann, Asaf</au><au>Elhaddad, Omar</au><au>Tole, Derek</au><au>Darcy, Kieren</au><au>Leadbetter, Duncan</au><au>Tuuminen, Raimo</au><au>Goldberg, Mordechai</au><au>Achiron, Asaf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudophakic cystoid macular oedema and posterior capsular opacification rates after combined phaco‐trabeculectomy vs. phaco alone</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2025-02</date><risdate>2025</risdate><volume>103</volume><issue>1</issue><spage>115</spage><epage>120</epage><pages>115-120</pages><issn>1755-375X</issn><issn>1755-3768</issn><eissn>1755-3768</eissn><abstract>Purpose
To assess the risk for pseudophakic cystoid macular oedema (PCME) and posterior capsular opacification (PCO) associated with combined cataract surgery and trabeculectomy compared to cataract surgery alone.
Methods
Data analysis of subjects who underwent routine cataract surgery without and with concomitant trabeculectomy at the Department of Ophthalmology, Bristol Eye Hospital, the UK, between January 2008 and December 2017. Odds ratios (ORs) for PCME between the types of surgeries were calculated using univariate and multivariate regression analysis. Multivariate Cox regression controlling for age and gender was used to estimate the hazard ratio (HR) for neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser capsulotomies.
Results
This study included 56 973 cataract surgeries without and 288 with concomitant trabeculectomy (phaco‐trab) with a mean follow‐up time of 6.9 ± 4.2 years. Baseline variables (age and gender, diabetes, pseudoexfoliation, use of pupil expansion device and postoperative follow‐up time) were comparable between the groups. Postoperative rates of PCME remained non‐significant between the cataract surgery and phaco‐trabe groups both in uni‐ and multi‐variate analysis (OR 0.347, 95%CI 0.049–2.477, p = 0.291). Furthermore, in Cox regression analysis adjusted for the patients' age and gender, Nd:YAG laser capsulotomy rates remained non‐significant between the cataract surgery and phaco‐trabe groups (HR 1.250, 95%CI 0.883–1.769, p = 0.209).
Conclusions
In our large cohort study, combining trabeculectomy with cataract surgery did not predispose to an increased PCME or Nd:YAG laser capsulotomy rates.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39394695</pmid><doi>10.1111/aos.16766</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6325-7175</orcidid><orcidid>https://orcid.org/0000-0003-1550-8125</orcidid><orcidid>https://orcid.org/0000-0001-7128-3288</orcidid><orcidid>https://orcid.org/0000-0001-6315-6908</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aluminum Capsule Opacification - diagnosis Capsule Opacification - epidemiology Capsule Opacification - etiology Capsule Opacification - surgery cataract surgery Cataracts Diabetes mellitus Edema Eye surgery Female Follow-Up Studies Gender Humans Incidence Lasers Macular Edema - diagnosis Macular Edema - etiology Macular Edema - surgery Male Middle Aged Original Phacoemulsification - adverse effects Phacoemulsification - methods posterior capsular opacification Postoperative Complications - epidemiology Pseudophakia - complications pseudophakic cystoid macular oedema Regression analysis Retrospective Studies Risk Factors Surgery trabeculectomy Trabeculectomy - methods Visual Acuity Yttrium |
title | Pseudophakic cystoid macular oedema and posterior capsular opacification rates after combined phaco‐trabeculectomy vs. phaco alone |
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