Marine bioactives: a new frontier in neurosurgical therapeutics
Bioactives derived from marine sources are opening up new therapeutic opportunities for neurosurgery. These include tissue regeneration, neuroprotection, and infection control. These molecules derived from extreme marine conditions have generated new modes of action, for example, selective inhibitio...
Gespeichert in:
| Veröffentlicht in: | Neurosurgical review 2024-10, Vol.47 (1), p.790, Article 790 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 790 |
| container_title | Neurosurgical review |
| container_volume | 47 |
| creator | C M, Mathan Muthu B, Bhavani Sowndharya A, Saravanan S, Vickram A |
| description | Bioactives derived from marine sources are opening up new therapeutic opportunities for neurosurgery. These include tissue regeneration, neuroprotection, and infection control. These molecules derived from extreme marine conditions have generated new modes of action, for example, selective inhibition of voltage-gated ion channels and influencing pathways of neuroinflammation. Representative examples include chitosan for nerve regeneration, conotoxins for pain modulation, and fucoidan for neuroprotection. Despite therapeutic promise, major challenges remain: those of sustainable sourcing and regulatory validation. This letter points up the potential of marine bioactives to change neurosurgical care and challenges the brain communities to work together across disciplines in order to make that happen. |
| doi_str_mv | 10.1007/s10143-024-03034-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3115771704</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3115771704</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-384edb3d9cce7327a0901a589bb51b51ebca3e14900a2d1e5e2d6a991eac25043</originalsourceid><addsrcrecordid>eNp9kE9LAzEQxYMotla_gAfZo5fVSSZrGi8ixX9Q8aLnkM1Oa0q7W5NdxW9v7FbxJAxkJnnvMfkxdszhjAOo88iBS8xByBwQUOa4w4bpRuUCBez-6QfsIMYFAFca-D4boEYtpdBDdvVog68pK31jXevfKV5mNqvpI5uFpm49hczXae5CE7sw984us_aVgl1T13oXD9nezC4jHW3PEXu5vXme3OfTp7uHyfU0d0KM2xzHkqoSK-0cKRTKQlrEFmNdlgVPRaWzSFxqACsqTgWJ6sJqzck6UYDEETvtc9eheesotmblo6Pl0tbUdNEg54VSXG2kope6tHMMNDPr4Fc2fBoO5huc6cGZBM5swBlMppNtfleuqPq1_JBKAuwFMT3Vcwpm0XShTn_-L_YLsRB4kw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3115771704</pqid></control><display><type>article</type><title>Marine bioactives: a new frontier in neurosurgical therapeutics</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>C M, Mathan Muthu ; B, Bhavani Sowndharya ; A, Saravanan ; S, Vickram A</creator><creatorcontrib>C M, Mathan Muthu ; B, Bhavani Sowndharya ; A, Saravanan ; S, Vickram A</creatorcontrib><description>Bioactives derived from marine sources are opening up new therapeutic opportunities for neurosurgery. These include tissue regeneration, neuroprotection, and infection control. These molecules derived from extreme marine conditions have generated new modes of action, for example, selective inhibition of voltage-gated ion channels and influencing pathways of neuroinflammation. Representative examples include chitosan for nerve regeneration, conotoxins for pain modulation, and fucoidan for neuroprotection. Despite therapeutic promise, major challenges remain: those of sustainable sourcing and regulatory validation. This letter points up the potential of marine bioactives to change neurosurgical care and challenges the brain communities to work together across disciplines in order to make that happen.</description><identifier>ISSN: 1437-2320</identifier><identifier>EISSN: 1437-2320</identifier><identifier>DOI: 10.1007/s10143-024-03034-3</identifier><identifier>PMID: 39394429</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Aquatic Organisms ; Biological Products - pharmacology ; Biological Products - therapeutic use ; Correspondence ; Humans ; Medicine ; Medicine & Public Health ; Nerve Regeneration - drug effects ; Neuroprotective Agents - therapeutic use ; Neurosurgery ; Neurosurgical Procedures - methods</subject><ispartof>Neurosurgical review, 2024-10, Vol.47 (1), p.790, Article 790</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-384edb3d9cce7327a0901a589bb51b51ebca3e14900a2d1e5e2d6a991eac25043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10143-024-03034-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10143-024-03034-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39394429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>C M, Mathan Muthu</creatorcontrib><creatorcontrib>B, Bhavani Sowndharya</creatorcontrib><creatorcontrib>A, Saravanan</creatorcontrib><creatorcontrib>S, Vickram A</creatorcontrib><title>Marine bioactives: a new frontier in neurosurgical therapeutics</title><title>Neurosurgical review</title><addtitle>Neurosurg Rev</addtitle><addtitle>Neurosurg Rev</addtitle><description>Bioactives derived from marine sources are opening up new therapeutic opportunities for neurosurgery. These include tissue regeneration, neuroprotection, and infection control. These molecules derived from extreme marine conditions have generated new modes of action, for example, selective inhibition of voltage-gated ion channels and influencing pathways of neuroinflammation. Representative examples include chitosan for nerve regeneration, conotoxins for pain modulation, and fucoidan for neuroprotection. Despite therapeutic promise, major challenges remain: those of sustainable sourcing and regulatory validation. This letter points up the potential of marine bioactives to change neurosurgical care and challenges the brain communities to work together across disciplines in order to make that happen.</description><subject>Animals</subject><subject>Aquatic Organisms</subject><subject>Biological Products - pharmacology</subject><subject>Biological Products - therapeutic use</subject><subject>Correspondence</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nerve Regeneration - drug effects</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neurosurgery</subject><subject>Neurosurgical Procedures - methods</subject><issn>1437-2320</issn><issn>1437-2320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMotla_gAfZo5fVSSZrGi8ixX9Q8aLnkM1Oa0q7W5NdxW9v7FbxJAxkJnnvMfkxdszhjAOo88iBS8xByBwQUOa4w4bpRuUCBez-6QfsIMYFAFca-D4boEYtpdBDdvVog68pK31jXevfKV5mNqvpI5uFpm49hczXae5CE7sw984us_aVgl1T13oXD9nezC4jHW3PEXu5vXme3OfTp7uHyfU0d0KM2xzHkqoSK-0cKRTKQlrEFmNdlgVPRaWzSFxqACsqTgWJ6sJqzck6UYDEETvtc9eheesotmblo6Pl0tbUdNEg54VSXG2kope6tHMMNDPr4Fc2fBoO5huc6cGZBM5swBlMppNtfleuqPq1_JBKAuwFMT3Vcwpm0XShTn_-L_YLsRB4kw</recordid><startdate>20241012</startdate><enddate>20241012</enddate><creator>C M, Mathan Muthu</creator><creator>B, Bhavani Sowndharya</creator><creator>A, Saravanan</creator><creator>S, Vickram A</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241012</creationdate><title>Marine bioactives: a new frontier in neurosurgical therapeutics</title><author>C M, Mathan Muthu ; B, Bhavani Sowndharya ; A, Saravanan ; S, Vickram A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-384edb3d9cce7327a0901a589bb51b51ebca3e14900a2d1e5e2d6a991eac25043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Aquatic Organisms</topic><topic>Biological Products - pharmacology</topic><topic>Biological Products - therapeutic use</topic><topic>Correspondence</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nerve Regeneration - drug effects</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neurosurgery</topic><topic>Neurosurgical Procedures - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>C M, Mathan Muthu</creatorcontrib><creatorcontrib>B, Bhavani Sowndharya</creatorcontrib><creatorcontrib>A, Saravanan</creatorcontrib><creatorcontrib>S, Vickram A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurosurgical review</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>C M, Mathan Muthu</au><au>B, Bhavani Sowndharya</au><au>A, Saravanan</au><au>S, Vickram A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marine bioactives: a new frontier in neurosurgical therapeutics</atitle><jtitle>Neurosurgical review</jtitle><stitle>Neurosurg Rev</stitle><addtitle>Neurosurg Rev</addtitle><date>2024-10-12</date><risdate>2024</risdate><volume>47</volume><issue>1</issue><spage>790</spage><pages>790-</pages><artnum>790</artnum><issn>1437-2320</issn><eissn>1437-2320</eissn><abstract>Bioactives derived from marine sources are opening up new therapeutic opportunities for neurosurgery. These include tissue regeneration, neuroprotection, and infection control. These molecules derived from extreme marine conditions have generated new modes of action, for example, selective inhibition of voltage-gated ion channels and influencing pathways of neuroinflammation. Representative examples include chitosan for nerve regeneration, conotoxins for pain modulation, and fucoidan for neuroprotection. Despite therapeutic promise, major challenges remain: those of sustainable sourcing and regulatory validation. This letter points up the potential of marine bioactives to change neurosurgical care and challenges the brain communities to work together across disciplines in order to make that happen.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39394429</pmid><doi>10.1007/s10143-024-03034-3</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1437-2320 |
| ispartof | Neurosurgical review, 2024-10, Vol.47 (1), p.790, Article 790 |
| issn | 1437-2320 1437-2320 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3115771704 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Animals Aquatic Organisms Biological Products - pharmacology Biological Products - therapeutic use Correspondence Humans Medicine Medicine & Public Health Nerve Regeneration - drug effects Neuroprotective Agents - therapeutic use Neurosurgery Neurosurgical Procedures - methods |
| title | Marine bioactives: a new frontier in neurosurgical therapeutics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T20%3A20%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Marine%20bioactives:%20a%20new%20frontier%20in%20neurosurgical%20therapeutics&rft.jtitle=Neurosurgical%20review&rft.au=C%20M,%20Mathan%20Muthu&rft.date=2024-10-12&rft.volume=47&rft.issue=1&rft.spage=790&rft.pages=790-&rft.artnum=790&rft.issn=1437-2320&rft.eissn=1437-2320&rft_id=info:doi/10.1007/s10143-024-03034-3&rft_dat=%3Cproquest_cross%3E3115771704%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3115771704&rft_id=info:pmid/39394429&rfr_iscdi=true |