Copper biomarkers and their relationship with parameters of insulin resistance in obese women
Some studies have demonstrated the involvement of high concentrations of copper in the manifestation of insulin resistance in individuals with obesity. The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obe...
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| Veröffentlicht in: | Biometals 2025-02, Vol.38 (1), p.173-183 |
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| creator | da Silva, Nilmara Cunha da Silva, Lyandra Dias Chaves, Bianca Mickaela Santos de Oliveira, Emyle Horrana Serafim Barros, Esmeralda Maria Lustosa de Oliveira, Francisco Erasmo Henriques, Gilberto Simeone Pereira, Irislene Costa Severo, Juliana Soares dos Santos, Loanne Rocha de Moura, Mayara Storel Beserra da Cunha Soares, Tamires de Sousa, Thayanne Gabryelle Visgueira de Sousa Melo, Stéfany Rodrigues do Nascimento Marreiro, Dilina |
| description | Some studies have demonstrated the involvement of high concentrations of copper in the manifestation of insulin resistance in individuals with obesity. The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case–control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p |
| doi_str_mv | 10.1007/s10534-024-00645-7 |
| format | Article |
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The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case–control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). The results of this study demonstrate that obese women have high copper concentrations in plasma and lower concentrations in erythrocytes. Furthermore, the significant positive correlation between plasma copper and fasting insulin and HOMA-IR index suggests the influence of this mineral on glycemic control parameters in obese women.</description><identifier>ISSN: 0966-0844</identifier><identifier>ISSN: 1572-8773</identifier><identifier>EISSN: 1572-8773</identifier><identifier>DOI: 10.1007/s10534-024-00645-7</identifier><identifier>PMID: 39392553</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Biochemistry ; Biomarkers ; Biomarkers - blood ; Biomedical and Life Sciences ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Body weight ; Case-Control Studies ; Cell Biology ; Ceruloplasmin ; Copper ; Copper - blood ; Dietary intake ; Erythrocytes ; Eutrophication ; Fasting ; Female ; Humans ; Insulin ; Insulin Resistance ; Life Sciences ; Medicine/Public Health ; Microbiology ; Middle Aged ; Nutritional status ; Obesity ; Obesity - blood ; Parameter identification ; Pharmacology/Toxicology ; Plant Physiology ; Plasma ; Statistical analysis ; Young Adult</subject><ispartof>Biometals, 2025-02, Vol.38 (1), p.173-183</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. 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The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case–control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). 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Furthermore, the significant positive correlation between plasma copper and fasting insulin and HOMA-IR index suggests the influence of this mineral on glycemic control parameters in obese women.</description><subject>Adult</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Body weight</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>Ceruloplasmin</subject><subject>Copper</subject><subject>Copper - blood</subject><subject>Dietary intake</subject><subject>Erythrocytes</subject><subject>Eutrophication</subject><subject>Fasting</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Life Sciences</subject><subject>Medicine/Public Health</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Nutritional status</subject><subject>Obesity</subject><subject>Obesity - 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The objective of this study was to evaluate the copper nutritional status and its relationship with parameters of glycemic control in women with obesity. An observational case–control clinical study involving 203 women aged between 20 and 50 years, divided into two groups: obese (n = 84) and eutrophic (n = 119). Body weight, height and waist, hip and neck circumferences, dietary copper intake, copper biomarkers, determine ceruloplasmin activity and glycemic control parameters were measured. It was observed that women with obesity had higher copper concentrations in plasma and lower concentrations in erythrocytes when compared to the control group. Analysis of glycemic control parameters revealed a statistically significant difference in fasting blood glucose (p < 0.05) between groups. The study identified a significant positive correlation between plasma copper and fasting insulin values and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index (p < 0.05). 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| subjects | Adult Biochemistry Biomarkers Biomarkers - blood Biomedical and Life Sciences Blood Glucose - analysis Blood Glucose - metabolism Body weight Case-Control Studies Cell Biology Ceruloplasmin Copper Copper - blood Dietary intake Erythrocytes Eutrophication Fasting Female Humans Insulin Insulin Resistance Life Sciences Medicine/Public Health Microbiology Middle Aged Nutritional status Obesity Obesity - blood Parameter identification Pharmacology/Toxicology Plant Physiology Plasma Statistical analysis Young Adult |
| title | Copper biomarkers and their relationship with parameters of insulin resistance in obese women |
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