APEX1 in intestinal epithelium triggers neutrophil infiltration and intestinal barrier damage in ulcerative colitis

Ulcerative colitis (UC) can lead to the generation of large amounts of reactive oxygen species and DNA damage. DNA repair caused by base excision repair (BER) enzymes is an important mechanism for maintaining genomic integrity. However, the specific relationship between the function of BER enzymes a...

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Veröffentlicht in:	Free radical biology & medicine 2024-11, Vol.225, p.359-373
Hauptverfasser:	Chen, Qian, Chen, TianYi, Xiao, He, Wang, Fangjie, Li, ChaoFan, Hu, Nana, Bao, Lingbo, Tong, Xueling, Feng, Yan, Xu, Yu, Li, ChunXue, Zhu, Jian wu, Wang, Dong, Li, Meng Xia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals APEX1 Apoptosis Chemokine CXCL1 - genetics Chemokine CXCL1 - metabolism Colitis, Ulcerative - genetics Colitis, Ulcerative - immunology Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colon - metabolism Colon - pathology CXCL1 Disease Models, Animal DNA Damage DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Epithelium Extracellular Traps - metabolism Female Gastrointestinal Microbiome Humans Interleukin-1beta - genetics Interleukin-1beta - metabolism Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Mice Mice, Inbred C57BL Mice, Knockout Neutrophil Neutrophil Infiltration Neutrophils - immunology Neutrophils - metabolism Neutrophils - pathology NF-kappa B - genetics NF-kappa B - metabolism
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