Prophylactic (R,S)-ketamine and (2S,6S)-hydroxynorketamine Decrease Fear Expression by Differentially Modulating Fear Neural Ensembles

We previously reported that a single injection of (R,S)-ketamine or its metabolite (2S,6S)-hydroxynorketamine (HNK) prior to stress attenuated learned fear. However, whether these drugs attenuate learned fear through divergent or convergent effects on neural activity remains to be determined. 129S6/...

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Veröffentlicht in:	Biological psychiatry (1969) 2024-10
Hauptverfasser:	Mastrodonato, Alessia, Jin, Michelle, Kee, Noelle, Lanio, Marcos, Tapia, Juliana, Quintana, Liliette, Muñoz Zamora, Andrea, Deng, Shi-Xian, Xu, Xiaoming, Landry, Donald W., Denny, Christine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	c-fos Contextual fear conditioning Depression Metabolite Neural network Stress
Online-Zugang:	Volltext
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