Occurrence of per- and polyfluoroalkyl substances in drinking water in China and health risk assessment based on a probabilistic approach
Per- and polyfluoroalkyl substances (PFASs) raise concerns due to their widespread distribution, persistence, and toxicity to humans. Current studies lack the use of exposure parameters for Chinese populations and probabilistic risk assessment (PRA) to assess health risks of PFASs. To provide a scie...
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Veröffentlicht in: | Journal of hazardous materials 2024-12, Vol.480, p.136072, Article 136072 |
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creator | Li, Linqian Cao, Suzhen Shang, Xiaochen Zhang, Liwen Guan, Jiacheng Shao, Kan Qin, Ning Duan, Xiaoli |
description | Per- and polyfluoroalkyl substances (PFASs) raise concerns due to their widespread distribution, persistence, and toxicity to humans. Current studies lack the use of exposure parameters for Chinese populations and probabilistic risk assessment (PRA) to assess health risks of PFASs. To provide a scientific basis for the standards of PFASs in drinking water in China, data on concentrations of nine PFASs in 649 drinking water samples were collected from China through literature review. The highest concentration of PFASs was 17.41 ± 20.06 ng/L for perfluorobutyric acid (PFBA). Higher concentrations of PFASs were found in the southeastern coastal and in Sichuan Province. The probability of exceeding the standardized limits for drinking water for PFOA and PFOS was 2.71 % and 0.91 %. PRA and deterministic risk assessment (DRA) were used to assess non-carcinogenic risks in different age groups and provinces. Health risks of PFASs from oral exposure notably exceeded dermal contact. The Hazard Quotient (HQ) for oral exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) exceeded the acceptable level with a certain probability. The non-carcinogenic risk of exposure to PFASs in drinking water was negligible for the majority of the Chinese population. The study indicates that China should increase research on limits of PFASs in drinking water to reduce the health risks.
[Display omitted]
•Higher per- and polyfluoroalkyl substances (PFASs) were found in southeast China.•PFASs concentrations were less likely to exceed Chinese drinking water standards.•Health risks of PFASs from oral exposure notably exceeded dermal contact.•Exposure to PFASs in drinking water may pose a potential non-carcinogenic risk. |
doi_str_mv | 10.1016/j.jhazmat.2024.136072 |
format | Article |
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[Display omitted]
•Higher per- and polyfluoroalkyl substances (PFASs) were found in southeast China.•PFASs concentrations were less likely to exceed Chinese drinking water standards.•Health risks of PFASs from oral exposure notably exceeded dermal contact.•Exposure to PFASs in drinking water may pose a potential non-carcinogenic risk.</description><identifier>ISSN: 0304-3894</identifier><identifier>ISSN: 1873-3336</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2024.136072</identifier><identifier>PMID: 39388858</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Alkanesulfonic Acids - analysis ; Caprylates - analysis ; Caprylates - toxicity ; China ; Drinking water ; Drinking Water - analysis ; Drinking Water - chemistry ; Environmental Exposure - analysis ; Fluorocarbons - analysis ; Fluorocarbons - toxicity ; Humans ; Non-carcinogenic risk ; Oral and dermal exposure ; PFASs ; PRA ; Probability ; Risk Assessment ; Water Pollutants, Chemical - analysis</subject><ispartof>Journal of hazardous materials, 2024-12, Vol.480, p.136072, Article 136072</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c243t-e9c2a2aa4b37c06999880cbbdcfc4c98d1d712730ab1f82acff172c30a5c78ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhazmat.2024.136072$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39388858$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Linqian</creatorcontrib><creatorcontrib>Cao, Suzhen</creatorcontrib><creatorcontrib>Shang, Xiaochen</creatorcontrib><creatorcontrib>Zhang, Liwen</creatorcontrib><creatorcontrib>Guan, Jiacheng</creatorcontrib><creatorcontrib>Shao, Kan</creatorcontrib><creatorcontrib>Qin, Ning</creatorcontrib><creatorcontrib>Duan, Xiaoli</creatorcontrib><title>Occurrence of per- and polyfluoroalkyl substances in drinking water in China and health risk assessment based on a probabilistic approach</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>Per- and polyfluoroalkyl substances (PFASs) raise concerns due to their widespread distribution, persistence, and toxicity to humans. Current studies lack the use of exposure parameters for Chinese populations and probabilistic risk assessment (PRA) to assess health risks of PFASs. To provide a scientific basis for the standards of PFASs in drinking water in China, data on concentrations of nine PFASs in 649 drinking water samples were collected from China through literature review. The highest concentration of PFASs was 17.41 ± 20.06 ng/L for perfluorobutyric acid (PFBA). Higher concentrations of PFASs were found in the southeastern coastal and in Sichuan Province. The probability of exceeding the standardized limits for drinking water for PFOA and PFOS was 2.71 % and 0.91 %. PRA and deterministic risk assessment (DRA) were used to assess non-carcinogenic risks in different age groups and provinces. Health risks of PFASs from oral exposure notably exceeded dermal contact. The Hazard Quotient (HQ) for oral exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) exceeded the acceptable level with a certain probability. The non-carcinogenic risk of exposure to PFASs in drinking water was negligible for the majority of the Chinese population. The study indicates that China should increase research on limits of PFASs in drinking water to reduce the health risks.
[Display omitted]
•Higher per- and polyfluoroalkyl substances (PFASs) were found in southeast China.•PFASs concentrations were less likely to exceed Chinese drinking water standards.•Health risks of PFASs from oral exposure notably exceeded dermal contact.•Exposure to PFASs in drinking water may pose a potential non-carcinogenic risk.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alkanesulfonic Acids - analysis</subject><subject>Caprylates - analysis</subject><subject>Caprylates - toxicity</subject><subject>China</subject><subject>Drinking water</subject><subject>Drinking Water - analysis</subject><subject>Drinking Water - chemistry</subject><subject>Environmental Exposure - analysis</subject><subject>Fluorocarbons - analysis</subject><subject>Fluorocarbons - toxicity</subject><subject>Humans</subject><subject>Non-carcinogenic risk</subject><subject>Oral and dermal exposure</subject><subject>PFASs</subject><subject>PRA</subject><subject>Probability</subject><subject>Risk Assessment</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>0304-3894</issn><issn>1873-3336</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-P0zAQxS3Eii2FjwDykUuKHSeNc0KoWliklfaye7Ymkwlx6_zBk7Aq34BvvSktXDlZY703T_N-QrzTaqOV3n7cb_Yt_Opg2qQqzTbabFWRvhArbQuTGGO2L8VKGZUlxpbZtXjNvFdK6SLPXolrUxprbW5X4vc94hwj9UhyaORIMZHQ13IcwrEJ8xAHCIdjkDxXPMGiYul7WUffH3z_XT7BRPH0s2t9D3-cLUGYWhk9HyQwE3NH_SQrYKrl0EuQYxwqqHzwPHmUMC4zYPtGXDUQmN5e3rV4_HLzsLtN7u6_ftt9vkswzcyUUIkppABZZQpU27IsrVVYVTU2mGFpa10XOi2Mgko3NgVsGl2kuMw5FpbIrMWH894l9sdMPLnOM1II0NMwszNa5_lS1dLRWuRnKcaBOVLjxug7iEenlTtRcHt3oeBOFNyZwuJ7f4mYq47qf66_tS-CT2cBLYf-9BQdoz8xqH0knFw9-P9EPAMkKp62</recordid><startdate>20241205</startdate><enddate>20241205</enddate><creator>Li, Linqian</creator><creator>Cao, Suzhen</creator><creator>Shang, Xiaochen</creator><creator>Zhang, Liwen</creator><creator>Guan, Jiacheng</creator><creator>Shao, Kan</creator><creator>Qin, Ning</creator><creator>Duan, Xiaoli</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241205</creationdate><title>Occurrence of per- and polyfluoroalkyl substances in drinking water in China and health risk assessment based on a probabilistic approach</title><author>Li, Linqian ; Cao, Suzhen ; Shang, Xiaochen ; Zhang, Liwen ; Guan, Jiacheng ; Shao, Kan ; Qin, Ning ; Duan, Xiaoli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c243t-e9c2a2aa4b37c06999880cbbdcfc4c98d1d712730ab1f82acff172c30a5c78ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alkanesulfonic Acids - analysis</topic><topic>Caprylates - analysis</topic><topic>Caprylates - toxicity</topic><topic>China</topic><topic>Drinking water</topic><topic>Drinking Water - analysis</topic><topic>Drinking Water - chemistry</topic><topic>Environmental Exposure - analysis</topic><topic>Fluorocarbons - analysis</topic><topic>Fluorocarbons - toxicity</topic><topic>Humans</topic><topic>Non-carcinogenic risk</topic><topic>Oral and dermal exposure</topic><topic>PFASs</topic><topic>PRA</topic><topic>Probability</topic><topic>Risk Assessment</topic><topic>Water Pollutants, Chemical - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Linqian</creatorcontrib><creatorcontrib>Cao, Suzhen</creatorcontrib><creatorcontrib>Shang, Xiaochen</creatorcontrib><creatorcontrib>Zhang, Liwen</creatorcontrib><creatorcontrib>Guan, Jiacheng</creatorcontrib><creatorcontrib>Shao, Kan</creatorcontrib><creatorcontrib>Qin, Ning</creatorcontrib><creatorcontrib>Duan, Xiaoli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hazardous materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Linqian</au><au>Cao, Suzhen</au><au>Shang, Xiaochen</au><au>Zhang, Liwen</au><au>Guan, Jiacheng</au><au>Shao, Kan</au><au>Qin, Ning</au><au>Duan, Xiaoli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occurrence of per- and polyfluoroalkyl substances in drinking water in China and health risk assessment based on a probabilistic approach</atitle><jtitle>Journal of hazardous materials</jtitle><addtitle>J Hazard Mater</addtitle><date>2024-12-05</date><risdate>2024</risdate><volume>480</volume><spage>136072</spage><pages>136072-</pages><artnum>136072</artnum><issn>0304-3894</issn><issn>1873-3336</issn><eissn>1873-3336</eissn><abstract>Per- and polyfluoroalkyl substances (PFASs) raise concerns due to their widespread distribution, persistence, and toxicity to humans. Current studies lack the use of exposure parameters for Chinese populations and probabilistic risk assessment (PRA) to assess health risks of PFASs. To provide a scientific basis for the standards of PFASs in drinking water in China, data on concentrations of nine PFASs in 649 drinking water samples were collected from China through literature review. The highest concentration of PFASs was 17.41 ± 20.06 ng/L for perfluorobutyric acid (PFBA). Higher concentrations of PFASs were found in the southeastern coastal and in Sichuan Province. The probability of exceeding the standardized limits for drinking water for PFOA and PFOS was 2.71 % and 0.91 %. PRA and deterministic risk assessment (DRA) were used to assess non-carcinogenic risks in different age groups and provinces. Health risks of PFASs from oral exposure notably exceeded dermal contact. The Hazard Quotient (HQ) for oral exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) exceeded the acceptable level with a certain probability. The non-carcinogenic risk of exposure to PFASs in drinking water was negligible for the majority of the Chinese population. The study indicates that China should increase research on limits of PFASs in drinking water to reduce the health risks.
[Display omitted]
•Higher per- and polyfluoroalkyl substances (PFASs) were found in southeast China.•PFASs concentrations were less likely to exceed Chinese drinking water standards.•Health risks of PFASs from oral exposure notably exceeded dermal contact.•Exposure to PFASs in drinking water may pose a potential non-carcinogenic risk.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39388858</pmid><doi>10.1016/j.jhazmat.2024.136072</doi></addata></record> |
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subjects | Adolescent Adult Alkanesulfonic Acids - analysis Caprylates - analysis Caprylates - toxicity China Drinking water Drinking Water - analysis Drinking Water - chemistry Environmental Exposure - analysis Fluorocarbons - analysis Fluorocarbons - toxicity Humans Non-carcinogenic risk Oral and dermal exposure PFASs PRA Probability Risk Assessment Water Pollutants, Chemical - analysis |
title | Occurrence of per- and polyfluoroalkyl substances in drinking water in China and health risk assessment based on a probabilistic approach |
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