The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice

•Both sexes gained weight on high-fat (HF) diet + low-dose streptozotocin (STZ).•Both sexes developed impaired oral glucose tolerance.•Only males developed fasting hyperglycemia.•Only males developed hyperinsulinemia and insulin resistance.•Principal component analysis revealed overall metabolic der...

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Veröffentlicht in:	Nutrition research (New York, N.Y.) N.Y.), 2024-11, Vol.131, p.135-146
Hauptverfasser:	Racine, Kathryn C., Iglesias-Carres, Lisard, Herring, Jacob A., Wieland, Kristopher L., Ellsworth, Peter N., Tessem, Jeffery S., Ferruzzi, Mario G., Kay, Colin D., Neilson, Andrew P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells biomarkers biomedical research Blood Glucose - metabolism Diabetes Diabetes Mellitus, Experimental Diabetes Mellitus, Type 2 Diet, Fat-Restricted Diet, High-Fat - adverse effects Disease Models, Animal Female females glucose glucose tolerance High-fat diet humans Hyperglycemia hyperinsulinemia Hyperinsulinism Insulin Insulin - blood Insulin Resistance Male males Mice Mice, Inbred C57BL noninsulin-dependent diabetes mellitus nutrition research Postprandial Period principal component analysis Sex Factors Sexual dimorphism Streptozocin streptozotocin
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