Shared and distinct alterations in brain morphology in children with ADHD and obesity: Reduced cortical surface area in ADHD and thickness in overweight/obesity

To investigate shared versus distinct differences in brain structure among children with ADHD and obesity, we examined the morphology of regions implicated in cognitive control and reward function in a single cross-sectional cohort of children with and without ADHD and overweight/obesity (OV/OB). Pa...

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Veröffentlicht in:	Journal of psychiatric research 2024-12, Vol.180, p.103-112
Hauptverfasser:	Rosch, Keri S., Thapaliya, Gita, Plotkin, Micah, Mostofsky, Stewart H., Carnell, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Attention Deficit Disorder with Hyperactivity - diagnostic imaging Attention Deficit Disorder with Hyperactivity - pathology Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Child Cross-Sectional Studies Female Humans Magnetic Resonance Imaging Male Obesity - diagnostic imaging Obesity - pathology Overweight - diagnostic imaging Overweight - pathology Pediatric Obesity - diagnostic imaging Pediatric Obesity - pathology
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Beschreibung
Zusammenfassung:	To investigate shared versus distinct differences in brain structure among children with ADHD and obesity, we examined the morphology of regions implicated in cognitive control and reward function in a single cross-sectional cohort of children with and without ADHD and overweight/obesity (OV/OB). Participants included 471 children ages 8–12 years with ADHD (n = 244; 58 OV/OB) and neurotypical (NT) controls (n = 227; 81 OV/OB) classified as healthy-weight (HW; BMI %ile 5th to
ISSN:	0022-3956 1879-1379 1879-1379
DOI:	10.1016/j.jpsychires.2024.10.002