No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence
•Serum lipids may be a potentially influencing factor for age-related hearing loss.•A Mendelian randomized analysis assessed the causal relationship between serum lipids and European elderly deafness.•No significant causal effects were found between serum lipids and presbycusis.•The association prev...
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| Veröffentlicht in: | Hearing research 2024-11, Vol.453, p.109128, Article 109128 |
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| creator | Ni, Tianyi Shen, Ziyu Lu, Xiuling Shi, Hekai Xie, Hongbo Yang, Siyi Zhuang, Wenjie Liu, Yuehong Han, Zhao |
| description | •Serum lipids may be a potentially influencing factor for age-related hearing loss.•A Mendelian randomized analysis assessed the causal relationship between serum lipids and European elderly deafness.•No significant causal effects were found between serum lipids and presbycusis.•The association previously observed may have been caused by confounding factors.
Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL. Serum lipids are a key risk factor for cardiovascular disease. Therefore, it may be a potentially influencing factor for elderly deafness. We conduct the study to analyze the causal relationship between serum lipids and European elderly deafness.
Using genetic variation data related to serum lipids (total cholesterol levels [TCL], total triglycerides levels [TGL], and lipoprotein fractions, including apolipoprotein A1 levels [APOA1L], apolipoprotein B levels [APOBL], high-density lipoprotein cholesterol levels [HDL], and low-density lipoprotein cholesterol levels [LDL]) as instrumental variables, the outcome events were summarized from the genome-wide association study data of elderly deafness, and Mendelian randomization (MR) analysis was used in our analysis. The relationship between serum lipids levels and ARHL was analyzed using five methods, including inverse variance weighted, weighted mode, MR-Egger, weighted median, and simple mode. The study aims to use bidirectional MR analysis.
Among all 5 methods, no significant causal effects were found between serum lipids (TCL OR = 0.936, p = .488; TGL OR = 0.955, p = 0.657; APOA1L OR = 0.864, p = .061; APOBL OR = 0.979, p = .786; HDL OR = 0.998, p = .979; LDL OR = 1.089, p = .281) and presbycusis.
The findings of MR causal inference analysis did not support the causal relationship between presbycusis and serum lipids, including cholesterol, triglycerides, and lipoprotein fractions (APOA1L, APOBL, HDL and LDL). |
| doi_str_mv | 10.1016/j.heares.2024.109128 |
| format | Article |
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Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL. Serum lipids are a key risk factor for cardiovascular disease. Therefore, it may be a potentially influencing factor for elderly deafness. We conduct the study to analyze the causal relationship between serum lipids and European elderly deafness.
Using genetic variation data related to serum lipids (total cholesterol levels [TCL], total triglycerides levels [TGL], and lipoprotein fractions, including apolipoprotein A1 levels [APOA1L], apolipoprotein B levels [APOBL], high-density lipoprotein cholesterol levels [HDL], and low-density lipoprotein cholesterol levels [LDL]) as instrumental variables, the outcome events were summarized from the genome-wide association study data of elderly deafness, and Mendelian randomization (MR) analysis was used in our analysis. The relationship between serum lipids levels and ARHL was analyzed using five methods, including inverse variance weighted, weighted mode, MR-Egger, weighted median, and simple mode. The study aims to use bidirectional MR analysis.
Among all 5 methods, no significant causal effects were found between serum lipids (TCL OR = 0.936, p = .488; TGL OR = 0.955, p = 0.657; APOA1L OR = 0.864, p = .061; APOBL OR = 0.979, p = .786; HDL OR = 0.998, p = .979; LDL OR = 1.089, p = .281) and presbycusis.
The findings of MR causal inference analysis did not support the causal relationship between presbycusis and serum lipids, including cholesterol, triglycerides, and lipoprotein fractions (APOA1L, APOBL, HDL and LDL).</description><identifier>ISSN: 0378-5955</identifier><identifier>ISSN: 1878-5891</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/j.heares.2024.109128</identifier><identifier>PMID: 39388794</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Age Factors ; Aged ; Aging - blood ; Apolipoprotein A-I - blood ; Apolipoprotein A-I - genetics ; Apolipoprotein B-100 - blood ; Apolipoprotein B-100 - genetics ; Biomarkers - blood ; Cardiovascular disease ; Cholesterol, HDL - blood ; Europe ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Hearing - genetics ; Humans ; Lipids - blood ; Male ; Mendelian randomization ; Mendelian Randomization Analysis ; Phenotype ; Presbycusis ; Presbycusis - blood ; Presbycusis - diagnosis ; Presbycusis - genetics ; Risk Factors ; Serum lipids ; Triglycerides - blood</subject><ispartof>Hearing research, 2024-11, Vol.453, p.109128, Article 109128</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-a08f35ed41fe171c87993049780e22999c7c4b5f6e46e3dbc45259dc7b98c04a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378595524001813$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39388794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ni, Tianyi</creatorcontrib><creatorcontrib>Shen, Ziyu</creatorcontrib><creatorcontrib>Lu, Xiuling</creatorcontrib><creatorcontrib>Shi, Hekai</creatorcontrib><creatorcontrib>Xie, Hongbo</creatorcontrib><creatorcontrib>Yang, Siyi</creatorcontrib><creatorcontrib>Zhuang, Wenjie</creatorcontrib><creatorcontrib>Liu, Yuehong</creatorcontrib><creatorcontrib>Han, Zhao</creatorcontrib><title>No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>•Serum lipids may be a potentially influencing factor for age-related hearing loss.•A Mendelian randomized analysis assessed the causal relationship between serum lipids and European elderly deafness.•No significant causal effects were found between serum lipids and presbycusis.•The association previously observed may have been caused by confounding factors.
Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL. Serum lipids are a key risk factor for cardiovascular disease. Therefore, it may be a potentially influencing factor for elderly deafness. We conduct the study to analyze the causal relationship between serum lipids and European elderly deafness.
Using genetic variation data related to serum lipids (total cholesterol levels [TCL], total triglycerides levels [TGL], and lipoprotein fractions, including apolipoprotein A1 levels [APOA1L], apolipoprotein B levels [APOBL], high-density lipoprotein cholesterol levels [HDL], and low-density lipoprotein cholesterol levels [LDL]) as instrumental variables, the outcome events were summarized from the genome-wide association study data of elderly deafness, and Mendelian randomization (MR) analysis was used in our analysis. The relationship between serum lipids levels and ARHL was analyzed using five methods, including inverse variance weighted, weighted mode, MR-Egger, weighted median, and simple mode. The study aims to use bidirectional MR analysis.
Among all 5 methods, no significant causal effects were found between serum lipids (TCL OR = 0.936, p = .488; TGL OR = 0.955, p = 0.657; APOA1L OR = 0.864, p = .061; APOBL OR = 0.979, p = .786; HDL OR = 0.998, p = .979; LDL OR = 1.089, p = .281) and presbycusis.
The findings of MR causal inference analysis did not support the causal relationship between presbycusis and serum lipids, including cholesterol, triglycerides, and lipoprotein fractions (APOA1L, APOBL, HDL and LDL).</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aging - blood</subject><subject>Apolipoprotein A-I - blood</subject><subject>Apolipoprotein A-I - genetics</subject><subject>Apolipoprotein B-100 - blood</subject><subject>Apolipoprotein B-100 - genetics</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Cholesterol, HDL - blood</subject><subject>Europe</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Hearing - genetics</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Mendelian randomization</subject><subject>Mendelian Randomization Analysis</subject><subject>Phenotype</subject><subject>Presbycusis</subject><subject>Presbycusis - blood</subject><subject>Presbycusis - diagnosis</subject><subject>Presbycusis - genetics</subject><subject>Risk Factors</subject><subject>Serum lipids</subject><subject>Triglycerides - blood</subject><issn>0378-5955</issn><issn>1878-5891</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOBCEURYnRaDv8gTEs3VTL2AUbE2OcEoeNrgkFr5RODS10daJfL2WpS1eQm_O4vIPQMSVzSujibDl_AxshzRlhIkeaMrWFZlSVqpBK0200I3y8ayn30H5KS0Ko5ILtoj2uuVKlFjNUP_bY2SHZBkdo7Dr0XXoLK5wgDi1uwir4hPsO21covgHweOwN3Stu-pRwZVOOMvEAnYcm2A5H2_m-DZ85h03w0Dk4RDu1bRIc_ZwH6OX66vnytrh_urm7vLgvHBN0XViiai7BC1oDLanLf9ScCF0qAoxprV3pRCXrBYgFcF85IZnU3pWVVo4Iyw_Q6fTuKvbvA6S1aUNy0DS2g35IhlMqhdas1BkVE-pi3iNCbVYxtDZ-GErMaNgszWTYjIbNZDiPnfw0DFUL_m_oV2kGzicA8p6bANEkF0YHPkRwa-P78H_DFy0ejx8</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Ni, Tianyi</creator><creator>Shen, Ziyu</creator><creator>Lu, Xiuling</creator><creator>Shi, Hekai</creator><creator>Xie, Hongbo</creator><creator>Yang, Siyi</creator><creator>Zhuang, Wenjie</creator><creator>Liu, Yuehong</creator><creator>Han, Zhao</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202411</creationdate><title>No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence</title><author>Ni, Tianyi ; Shen, Ziyu ; Lu, Xiuling ; Shi, Hekai ; Xie, Hongbo ; Yang, Siyi ; Zhuang, Wenjie ; Liu, Yuehong ; Han, Zhao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-a08f35ed41fe171c87993049780e22999c7c4b5f6e46e3dbc45259dc7b98c04a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aging - blood</topic><topic>Apolipoprotein A-I - blood</topic><topic>Apolipoprotein A-I - genetics</topic><topic>Apolipoprotein B-100 - blood</topic><topic>Apolipoprotein B-100 - genetics</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Cholesterol, HDL - blood</topic><topic>Europe</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Hearing - genetics</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Mendelian randomization</topic><topic>Mendelian Randomization Analysis</topic><topic>Phenotype</topic><topic>Presbycusis</topic><topic>Presbycusis - blood</topic><topic>Presbycusis - diagnosis</topic><topic>Presbycusis - genetics</topic><topic>Risk Factors</topic><topic>Serum lipids</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ni, Tianyi</creatorcontrib><creatorcontrib>Shen, Ziyu</creatorcontrib><creatorcontrib>Lu, Xiuling</creatorcontrib><creatorcontrib>Shi, Hekai</creatorcontrib><creatorcontrib>Xie, Hongbo</creatorcontrib><creatorcontrib>Yang, Siyi</creatorcontrib><creatorcontrib>Zhuang, Wenjie</creatorcontrib><creatorcontrib>Liu, Yuehong</creatorcontrib><creatorcontrib>Han, Zhao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ni, Tianyi</au><au>Shen, Ziyu</au><au>Lu, Xiuling</au><au>Shi, Hekai</au><au>Xie, Hongbo</au><au>Yang, Siyi</au><au>Zhuang, Wenjie</au><au>Liu, Yuehong</au><au>Han, Zhao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>2024-11</date><risdate>2024</risdate><volume>453</volume><spage>109128</spage><pages>109128-</pages><artnum>109128</artnum><issn>0378-5955</issn><issn>1878-5891</issn><eissn>1878-5891</eissn><abstract>•Serum lipids may be a potentially influencing factor for age-related hearing loss.•A Mendelian randomized analysis assessed the causal relationship between serum lipids and European elderly deafness.•No significant causal effects were found between serum lipids and presbycusis.•The association previously observed may have been caused by confounding factors.
Presbycusis, or age-related hearing loss (ARHL) has been a common disability disease among the elderly population. It is particularly essential to identify the underlying role of related risk factors for ARHL diagnosis and treatment. Observational studies have shown that cardiovascular disease may be a factor in ARHL. Serum lipids are a key risk factor for cardiovascular disease. Therefore, it may be a potentially influencing factor for elderly deafness. We conduct the study to analyze the causal relationship between serum lipids and European elderly deafness.
Using genetic variation data related to serum lipids (total cholesterol levels [TCL], total triglycerides levels [TGL], and lipoprotein fractions, including apolipoprotein A1 levels [APOA1L], apolipoprotein B levels [APOBL], high-density lipoprotein cholesterol levels [HDL], and low-density lipoprotein cholesterol levels [LDL]) as instrumental variables, the outcome events were summarized from the genome-wide association study data of elderly deafness, and Mendelian randomization (MR) analysis was used in our analysis. The relationship between serum lipids levels and ARHL was analyzed using five methods, including inverse variance weighted, weighted mode, MR-Egger, weighted median, and simple mode. The study aims to use bidirectional MR analysis.
Among all 5 methods, no significant causal effects were found between serum lipids (TCL OR = 0.936, p = .488; TGL OR = 0.955, p = 0.657; APOA1L OR = 0.864, p = .061; APOBL OR = 0.979, p = .786; HDL OR = 0.998, p = .979; LDL OR = 1.089, p = .281) and presbycusis.
The findings of MR causal inference analysis did not support the causal relationship between presbycusis and serum lipids, including cholesterol, triglycerides, and lipoprotein fractions (APOA1L, APOBL, HDL and LDL).</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39388794</pmid><doi>10.1016/j.heares.2024.109128</doi></addata></record> |
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| subjects | Age Factors Aged Aging - blood Apolipoprotein A-I - blood Apolipoprotein A-I - genetics Apolipoprotein B-100 - blood Apolipoprotein B-100 - genetics Biomarkers - blood Cardiovascular disease Cholesterol, HDL - blood Europe Female Genetic Predisposition to Disease Genome-Wide Association Study Hearing - genetics Humans Lipids - blood Male Mendelian randomization Mendelian Randomization Analysis Phenotype Presbycusis Presbycusis - blood Presbycusis - diagnosis Presbycusis - genetics Risk Factors Serum lipids Triglycerides - blood |
| title | No causal relationship serum lipids on age-related hearing loss based on Mendelian randomized evidence |
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