Impaired 11β-hydroxysteroid dehydrogenase type 2 activity in kidney disease disrupts 11-oxygenated androgen biosynthesis

11-oxygenated androgens are a group of adrenal-derived steroids that require peripheral activation. In vitro data highlight a putative role for 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) in 11-oxygenated androgen biosynthesis, converting 11β-hydroxyandrostenedione (11OHA4) to 11-ketoandrosten...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2024-10
Hauptverfasser:	Tomkins, Maria, McDonnell, Tara, Cussen, Leanne, Sagmeister, Michael S, Oestlund, Imken, Shaheen, Fozia, Harper, Lorraine, Hardy, Rowan S, Taylor, Angela E, Gilligan, Lorna C, Arlt, Wiebke, McIlroy, Marie, de Freitas, Declan, Conlon, Peter, Magee, Colm, Denton, Mark, O'Seaghdha, Conall, Snoep, Jacky L, Storbeck, Karl-Heinz, Sherlock, Mark, O'Reilly, Michael W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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