hsa-miR-582-3p in umbilical cord blood is negatively associated with maternal exposure to childhood maltreatment
Childhood maltreatment (CM) may affect not only directly exposed individuals but also their offspring. However, the underlying biological mechanisms remain unclear. microRNAs (miRNAs) may play a regulatory role in this process. This study investigates the relationship between maternal exposure to CM...
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| Veröffentlicht in: | Epigenomics 2024, Vol.16 (19-20), p.1273-1286 |
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| container_title | Epigenomics |
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| creator | Micali, Danilo Rosa, Joice Santos Ota, Vanessa Kiyomi Vieira Mercuri, Rafael Luiz Spindola, Leticia Maria Gomes Bugiga, Amanda Victória Kajitani, Gustavo Satoru Coelho Milani, Ana Carolina Salmeron, Camilla Silva, Ivaldo Fontes Asprino, Paula Galante, Pedro Af Seixas Duarte, Cristiane Posner, Jonathan Parolin Jackowski, Andrea Belangero, Sintia Iole |
| description | Childhood maltreatment (CM) may affect not only directly exposed individuals but also their offspring. However, the underlying biological mechanisms remain unclear. microRNAs (miRNAs) may play a regulatory role in this process. This study investigates the relationship between maternal exposure to CM and miRNA expression in maternal and perinatal tissues.
We enrolled 43 pregnant women and assessed their CM exposure. We collected maternal blood, cord blood and placental tissue samples during childbirth and performed miRNA profiling using next generation sequencing.
Maternal CM was inversely associated with hsa-miR-582-3p levels in cord blood. Pathway analysis revealed that this miRNA regulates genes involved in intrauterine development.
Our findings highlight the potential impact of maternal CM exposure on offspring epigenetic mechanisms. |
| doi_str_mv | 10.1080/17501911.2024.2401318 |
| format | Article |
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We enrolled 43 pregnant women and assessed their CM exposure. We collected maternal blood, cord blood and placental tissue samples during childbirth and performed miRNA profiling using next generation sequencing.
Maternal CM was inversely associated with hsa-miR-582-3p levels in cord blood. Pathway analysis revealed that this miRNA regulates genes involved in intrauterine development.
Our findings highlight the potential impact of maternal CM exposure on offspring epigenetic mechanisms.</description><identifier>ISSN: 1750-1911</identifier><identifier>ISSN: 1750-192X</identifier><identifier>EISSN: 1750-192X</identifier><identifier>DOI: 10.1080/17501911.2024.2401318</identifier><identifier>PMID: 39382450</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Child ; Child Abuse ; Epigenesis, Genetic ; Female ; Fetal Blood - metabolism ; Humans ; Maternal Exposure - adverse effects ; MicroRNAs - blood ; MicroRNAs - genetics ; Placenta - metabolism ; Pregnancy</subject><ispartof>Epigenomics, 2024, Vol.16 (19-20), p.1273-1286</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c187t-f2e061848f1e69311a59dfc9d54226089331ced323cd190b36f969a1ad565cbb3</cites><orcidid>0000-0002-2370-943X ; 0000-0002-2157-5853 ; 0009-0002-4052-301X ; 0000-0002-9190-654X ; 0000-0002-1395-0342 ; 0000-0002-9988-1498 ; 0000-0003-0129-6360 ; 0000-0001-7214-4255 ; 0000-0003-2842-8423 ; 0000-0002-8399-878X ; 0000-0002-2419-4351 ; 0000-0002-4820-4155 ; 0009-0008-8378-4029 ; 0000-0001-8842-5406</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39382450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Micali, Danilo</creatorcontrib><creatorcontrib>Rosa, Joice Santos</creatorcontrib><creatorcontrib>Ota, Vanessa Kiyomi</creatorcontrib><creatorcontrib>Vieira Mercuri, Rafael Luiz</creatorcontrib><creatorcontrib>Spindola, Leticia Maria</creatorcontrib><creatorcontrib>Gomes Bugiga, Amanda Victória</creatorcontrib><creatorcontrib>Kajitani, Gustavo Satoru</creatorcontrib><creatorcontrib>Coelho Milani, Ana Carolina</creatorcontrib><creatorcontrib>Salmeron, Camilla</creatorcontrib><creatorcontrib>Silva, Ivaldo</creatorcontrib><creatorcontrib>Fontes Asprino, Paula</creatorcontrib><creatorcontrib>Galante, Pedro Af</creatorcontrib><creatorcontrib>Seixas Duarte, Cristiane</creatorcontrib><creatorcontrib>Posner, Jonathan</creatorcontrib><creatorcontrib>Parolin Jackowski, Andrea</creatorcontrib><creatorcontrib>Belangero, Sintia Iole</creatorcontrib><title>hsa-miR-582-3p in umbilical cord blood is negatively associated with maternal exposure to childhood maltreatment</title><title>Epigenomics</title><addtitle>Epigenomics</addtitle><description>Childhood maltreatment (CM) may affect not only directly exposed individuals but also their offspring. However, the underlying biological mechanisms remain unclear. microRNAs (miRNAs) may play a regulatory role in this process. This study investigates the relationship between maternal exposure to CM and miRNA expression in maternal and perinatal tissues.
We enrolled 43 pregnant women and assessed their CM exposure. We collected maternal blood, cord blood and placental tissue samples during childbirth and performed miRNA profiling using next generation sequencing.
Maternal CM was inversely associated with hsa-miR-582-3p levels in cord blood. Pathway analysis revealed that this miRNA regulates genes involved in intrauterine development.
Our findings highlight the potential impact of maternal CM exposure on offspring epigenetic mechanisms.</description><subject>Adult</subject><subject>Child</subject><subject>Child Abuse</subject><subject>Epigenesis, Genetic</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Humans</subject><subject>Maternal Exposure - adverse effects</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><issn>1750-1911</issn><issn>1750-192X</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LxDAQxYMoKrofQcnRS9dM0nSToyz-A0EQBW8lTVI3kjY1SdX99nbZdecyj-G9N_BD6ALIHIgg17DgBCTAnBJazmlJgIE4QKebewGSvh_uNcAJmqX0SaZhVMgKjtEJk0zQkpNTNKySKjr3UnBBCzZg1-Oxa5x3WnmsQzS48SEY7BLu7YfK7tv6NVYpBe1Utgb_uLzC3SRjPyXs7xDSGC3OAeuV82a1CXfK52hV7myfz9FRq3yys90-Q293t6_Lh-Lp-f5xefNUaBCLXLTUkgpEKVqwlWQAikvTaml4SWlFhGQMtDWMMm1AkoZVraykAmV4xXXTsDN0te0dYvgabcp155K23qvehjHVU-UEgJaCT1a-teoYUoq2rYfoOhXXNZB6w7v-511veNc73lPucvdibDpr9ql_uuwPHD17BA</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Micali, Danilo</creator><creator>Rosa, Joice Santos</creator><creator>Ota, Vanessa Kiyomi</creator><creator>Vieira Mercuri, Rafael Luiz</creator><creator>Spindola, Leticia Maria</creator><creator>Gomes Bugiga, Amanda Victória</creator><creator>Kajitani, Gustavo Satoru</creator><creator>Coelho Milani, Ana Carolina</creator><creator>Salmeron, Camilla</creator><creator>Silva, Ivaldo</creator><creator>Fontes Asprino, Paula</creator><creator>Galante, Pedro Af</creator><creator>Seixas Duarte, Cristiane</creator><creator>Posner, Jonathan</creator><creator>Parolin Jackowski, Andrea</creator><creator>Belangero, Sintia Iole</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2370-943X</orcidid><orcidid>https://orcid.org/0000-0002-2157-5853</orcidid><orcidid>https://orcid.org/0009-0002-4052-301X</orcidid><orcidid>https://orcid.org/0000-0002-9190-654X</orcidid><orcidid>https://orcid.org/0000-0002-1395-0342</orcidid><orcidid>https://orcid.org/0000-0002-9988-1498</orcidid><orcidid>https://orcid.org/0000-0003-0129-6360</orcidid><orcidid>https://orcid.org/0000-0001-7214-4255</orcidid><orcidid>https://orcid.org/0000-0003-2842-8423</orcidid><orcidid>https://orcid.org/0000-0002-8399-878X</orcidid><orcidid>https://orcid.org/0000-0002-2419-4351</orcidid><orcidid>https://orcid.org/0000-0002-4820-4155</orcidid><orcidid>https://orcid.org/0009-0008-8378-4029</orcidid><orcidid>https://orcid.org/0000-0001-8842-5406</orcidid></search><sort><creationdate>2024</creationdate><title>hsa-miR-582-3p in umbilical cord blood is negatively associated with maternal exposure to childhood maltreatment</title><author>Micali, Danilo ; Rosa, Joice Santos ; Ota, Vanessa Kiyomi ; Vieira Mercuri, Rafael Luiz ; Spindola, Leticia Maria ; Gomes Bugiga, Amanda Victória ; Kajitani, Gustavo Satoru ; Coelho Milani, Ana Carolina ; Salmeron, Camilla ; Silva, Ivaldo ; Fontes Asprino, Paula ; Galante, Pedro Af ; Seixas Duarte, Cristiane ; Posner, Jonathan ; Parolin Jackowski, Andrea ; Belangero, Sintia Iole</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c187t-f2e061848f1e69311a59dfc9d54226089331ced323cd190b36f969a1ad565cbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Child</topic><topic>Child Abuse</topic><topic>Epigenesis, Genetic</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Humans</topic><topic>Maternal Exposure - adverse effects</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - genetics</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Micali, Danilo</creatorcontrib><creatorcontrib>Rosa, Joice Santos</creatorcontrib><creatorcontrib>Ota, Vanessa Kiyomi</creatorcontrib><creatorcontrib>Vieira Mercuri, Rafael Luiz</creatorcontrib><creatorcontrib>Spindola, Leticia Maria</creatorcontrib><creatorcontrib>Gomes Bugiga, Amanda Victória</creatorcontrib><creatorcontrib>Kajitani, Gustavo Satoru</creatorcontrib><creatorcontrib>Coelho Milani, Ana Carolina</creatorcontrib><creatorcontrib>Salmeron, Camilla</creatorcontrib><creatorcontrib>Silva, Ivaldo</creatorcontrib><creatorcontrib>Fontes Asprino, Paula</creatorcontrib><creatorcontrib>Galante, Pedro Af</creatorcontrib><creatorcontrib>Seixas Duarte, Cristiane</creatorcontrib><creatorcontrib>Posner, Jonathan</creatorcontrib><creatorcontrib>Parolin Jackowski, Andrea</creatorcontrib><creatorcontrib>Belangero, Sintia Iole</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Micali, Danilo</au><au>Rosa, Joice Santos</au><au>Ota, Vanessa Kiyomi</au><au>Vieira Mercuri, Rafael Luiz</au><au>Spindola, Leticia Maria</au><au>Gomes Bugiga, Amanda Victória</au><au>Kajitani, Gustavo Satoru</au><au>Coelho Milani, Ana Carolina</au><au>Salmeron, Camilla</au><au>Silva, Ivaldo</au><au>Fontes Asprino, Paula</au><au>Galante, Pedro Af</au><au>Seixas Duarte, Cristiane</au><au>Posner, Jonathan</au><au>Parolin Jackowski, Andrea</au><au>Belangero, Sintia Iole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>hsa-miR-582-3p in umbilical cord blood is negatively associated with maternal exposure to childhood maltreatment</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2024</date><risdate>2024</risdate><volume>16</volume><issue>19-20</issue><spage>1273</spage><epage>1286</epage><pages>1273-1286</pages><issn>1750-1911</issn><issn>1750-192X</issn><eissn>1750-192X</eissn><abstract>Childhood maltreatment (CM) may affect not only directly exposed individuals but also their offspring. However, the underlying biological mechanisms remain unclear. microRNAs (miRNAs) may play a regulatory role in this process. This study investigates the relationship between maternal exposure to CM and miRNA expression in maternal and perinatal tissues.
We enrolled 43 pregnant women and assessed their CM exposure. We collected maternal blood, cord blood and placental tissue samples during childbirth and performed miRNA profiling using next generation sequencing.
Maternal CM was inversely associated with hsa-miR-582-3p levels in cord blood. Pathway analysis revealed that this miRNA regulates genes involved in intrauterine development.
Our findings highlight the potential impact of maternal CM exposure on offspring epigenetic mechanisms.</abstract><cop>England</cop><pmid>39382450</pmid><doi>10.1080/17501911.2024.2401318</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-2370-943X</orcidid><orcidid>https://orcid.org/0000-0002-2157-5853</orcidid><orcidid>https://orcid.org/0009-0002-4052-301X</orcidid><orcidid>https://orcid.org/0000-0002-9190-654X</orcidid><orcidid>https://orcid.org/0000-0002-1395-0342</orcidid><orcidid>https://orcid.org/0000-0002-9988-1498</orcidid><orcidid>https://orcid.org/0000-0003-0129-6360</orcidid><orcidid>https://orcid.org/0000-0001-7214-4255</orcidid><orcidid>https://orcid.org/0000-0003-2842-8423</orcidid><orcidid>https://orcid.org/0000-0002-8399-878X</orcidid><orcidid>https://orcid.org/0000-0002-2419-4351</orcidid><orcidid>https://orcid.org/0000-0002-4820-4155</orcidid><orcidid>https://orcid.org/0009-0008-8378-4029</orcidid><orcidid>https://orcid.org/0000-0001-8842-5406</orcidid></addata></record> |
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| identifier | ISSN: 1750-1911 |
| ispartof | Epigenomics, 2024, Vol.16 (19-20), p.1273-1286 |
| issn | 1750-1911 1750-192X 1750-192X |
| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Adult Child Child Abuse Epigenesis, Genetic Female Fetal Blood - metabolism Humans Maternal Exposure - adverse effects MicroRNAs - blood MicroRNAs - genetics Placenta - metabolism Pregnancy |
| title | hsa-miR-582-3p in umbilical cord blood is negatively associated with maternal exposure to childhood maltreatment |
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