Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study
Background Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent. Methods In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CRC risk in 78,467 Korean adults aged...
Gespeichert in:
| Veröffentlicht in: | British journal of cancer 2024-11, Vol.131 (10), p.1635-1643 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1643 |
|---|---|
| container_issue | 10 |
| container_start_page | 1635 |
| container_title | British journal of cancer |
| container_volume | 131 |
| creator | Noh, Hwayoung Lee, Jeeyoo Seyed Khoei, Nazlisadat Peruchet-Noray, Laia Kang, Daehee Fervers, Beatrice Wagner, Karl-Heinz Shin, Aesun Freisling, Heinz |
| description | Background
Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent.
Methods
In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CRC risk in 78,467 Korean adults aged 40–78 years at recruitment, considering potential non-linearity and sex differences. Hazard ratios (HR) and 95% confidence intervals (CI) for associations with CRC risk were estimated with Cox proportional hazard regression.
Results
During a median 7.9-year follow-up, 539 incident CRC cases were recorded. In multivariable-adjusted models, higher levels of total bilirubin were associated with a 26% (CI: 42% to 7%) lower risk of CRC among men and women combined, comparing the highest with the lowest tertile (
P
-linear trend = 0.003). A U-shaped association was observed in men, with the lowest risk at approximately 0.8 mg/dL (=13.7 μmol/L) of total bilirubin (
P
for non-linearity = 0.01). Although the association was largely null in women, there was no evidence for effect modification by sex (
P
-interaction = 0.73). Associations between indirect bilirubin and CRC risk were similar.
Conclusions
Higher circulating levels of total and indirect bilirubin were inversely associated with the risk of CRC among Korean adults. The associations were strongly inverse and U-shaped among men. |
| doi_str_mv | 10.1038/s41416-024-02847-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3114499677</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3126812974</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-8b11d53ede8e6faac48eed9e749f83d8aeb667dba8b1151b70a5042a233059793</originalsourceid><addsrcrecordid>eNp9kctu1DAUhi0EokPhBVggS2zKIuBbYptdNQozqJVYDEjsIic-6bg48WAniHkhnhNP04LEgoXly_nO7yN9CL2k5C0lXL1LggpaFYSJvJSQhX6EVrTkrKCKycdoRQiRBdGMnKFnKd3mqyZKPkVnXHOpS0lW6NcO4jzg1nkX59aN2MMP8Amb0eLo0jccetwFHyJ0k_G4M2MHEWfuKj-ZERs7-ym9xxHS6YD7GAY87eGhvoExDHAXVx-chcHlsJsj3k2zPRZbMH7a4_qnGdwIgC-uwqbeFdv66-UbvA77EKeFfI6e9MYneHG_n6MvH-rP621x_WnzcX15XXSsrKZCtZTakoMFBVVvTCcUgNUghe4Vt8pAW1XStuYElrSVxJREMMM4J6WWmp-jiyX3EMP3GdLUDC514L0ZIcyp4ZQKoXUlZUZf_4PehjmOebpMsUpRpqXIFFuoLoaUIvTNIbrBxGNDSXOy2CwWm2yxubPYnKZ4dR89twPYPy0P2jLAFyDl0ngD8e_f_4n9DQh8qPM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3126812974</pqid></control><display><type>article</type><title>Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Noh, Hwayoung ; Lee, Jeeyoo ; Seyed Khoei, Nazlisadat ; Peruchet-Noray, Laia ; Kang, Daehee ; Fervers, Beatrice ; Wagner, Karl-Heinz ; Shin, Aesun ; Freisling, Heinz</creator><creatorcontrib>Noh, Hwayoung ; Lee, Jeeyoo ; Seyed Khoei, Nazlisadat ; Peruchet-Noray, Laia ; Kang, Daehee ; Fervers, Beatrice ; Wagner, Karl-Heinz ; Shin, Aesun ; Freisling, Heinz</creatorcontrib><description>Background
Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent.
Methods
In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CRC risk in 78,467 Korean adults aged 40–78 years at recruitment, considering potential non-linearity and sex differences. Hazard ratios (HR) and 95% confidence intervals (CI) for associations with CRC risk were estimated with Cox proportional hazard regression.
Results
During a median 7.9-year follow-up, 539 incident CRC cases were recorded. In multivariable-adjusted models, higher levels of total bilirubin were associated with a 26% (CI: 42% to 7%) lower risk of CRC among men and women combined, comparing the highest with the lowest tertile (
P
-linear trend = 0.003). A U-shaped association was observed in men, with the lowest risk at approximately 0.8 mg/dL (=13.7 μmol/L) of total bilirubin (
P
for non-linearity = 0.01). Although the association was largely null in women, there was no evidence for effect modification by sex (
P
-interaction = 0.73). Associations between indirect bilirubin and CRC risk were similar.
Conclusions
Higher circulating levels of total and indirect bilirubin were inversely associated with the risk of CRC among Korean adults. The associations were strongly inverse and U-shaped among men.</description><identifier>ISSN: 0007-0920</identifier><identifier>ISSN: 1532-1827</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/s41416-024-02847-9</identifier><identifier>PMID: 39379570</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/67/2324 ; Adult ; Adults ; Aged ; Bilirubin ; Bilirubin - blood ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cohort analysis ; Cohort Studies ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - epidemiology ; Drug Resistance ; Epidemiology ; Female ; Gender differences ; Genomes ; Health risks ; Humans ; Male ; Middle Aged ; Molecular Medicine ; Oncology ; Proportional Hazards Models ; Prospective Studies ; Republic of Korea - epidemiology ; Risk Factors ; Sex differences</subject><ispartof>British journal of cancer, 2024-11, Vol.131 (10), p.1635-1643</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature Limited.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-8b11d53ede8e6faac48eed9e749f83d8aeb667dba8b1151b70a5042a233059793</cites><orcidid>0000-0001-8742-8920 ; 0000-0001-8648-4998 ; 0000-0002-1683-7265 ; 0000-0001-6003-7794 ; 0000-0002-6426-1969</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41416-024-02847-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41416-024-02847-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39379570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noh, Hwayoung</creatorcontrib><creatorcontrib>Lee, Jeeyoo</creatorcontrib><creatorcontrib>Seyed Khoei, Nazlisadat</creatorcontrib><creatorcontrib>Peruchet-Noray, Laia</creatorcontrib><creatorcontrib>Kang, Daehee</creatorcontrib><creatorcontrib>Fervers, Beatrice</creatorcontrib><creatorcontrib>Wagner, Karl-Heinz</creatorcontrib><creatorcontrib>Shin, Aesun</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><title>Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background
Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent.
Methods
In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CRC risk in 78,467 Korean adults aged 40–78 years at recruitment, considering potential non-linearity and sex differences. Hazard ratios (HR) and 95% confidence intervals (CI) for associations with CRC risk were estimated with Cox proportional hazard regression.
Results
During a median 7.9-year follow-up, 539 incident CRC cases were recorded. In multivariable-adjusted models, higher levels of total bilirubin were associated with a 26% (CI: 42% to 7%) lower risk of CRC among men and women combined, comparing the highest with the lowest tertile (
P
-linear trend = 0.003). A U-shaped association was observed in men, with the lowest risk at approximately 0.8 mg/dL (=13.7 μmol/L) of total bilirubin (
P
for non-linearity = 0.01). Although the association was largely null in women, there was no evidence for effect modification by sex (
P
-interaction = 0.73). Associations between indirect bilirubin and CRC risk were similar.
Conclusions
Higher circulating levels of total and indirect bilirubin were inversely associated with the risk of CRC among Korean adults. The associations were strongly inverse and U-shaped among men.</description><subject>692/499</subject><subject>692/699/67/2324</subject><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Bilirubin</subject><subject>Bilirubin - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gender differences</subject><subject>Genomes</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Sex differences</subject><issn>0007-0920</issn><issn>1532-1827</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1DAUhi0EokPhBVggS2zKIuBbYptdNQozqJVYDEjsIic-6bg48WAniHkhnhNP04LEgoXly_nO7yN9CL2k5C0lXL1LggpaFYSJvJSQhX6EVrTkrKCKycdoRQiRBdGMnKFnKd3mqyZKPkVnXHOpS0lW6NcO4jzg1nkX59aN2MMP8Amb0eLo0jccetwFHyJ0k_G4M2MHEWfuKj-ZERs7-ym9xxHS6YD7GAY87eGhvoExDHAXVx-chcHlsJsj3k2zPRZbMH7a4_qnGdwIgC-uwqbeFdv66-UbvA77EKeFfI6e9MYneHG_n6MvH-rP621x_WnzcX15XXSsrKZCtZTakoMFBVVvTCcUgNUghe4Vt8pAW1XStuYElrSVxJREMMM4J6WWmp-jiyX3EMP3GdLUDC514L0ZIcyp4ZQKoXUlZUZf_4PehjmOebpMsUpRpqXIFFuoLoaUIvTNIbrBxGNDSXOy2CwWm2yxubPYnKZ4dR89twPYPy0P2jLAFyDl0ngD8e_f_4n9DQh8qPM</recordid><startdate>20241130</startdate><enddate>20241130</enddate><creator>Noh, Hwayoung</creator><creator>Lee, Jeeyoo</creator><creator>Seyed Khoei, Nazlisadat</creator><creator>Peruchet-Noray, Laia</creator><creator>Kang, Daehee</creator><creator>Fervers, Beatrice</creator><creator>Wagner, Karl-Heinz</creator><creator>Shin, Aesun</creator><creator>Freisling, Heinz</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8742-8920</orcidid><orcidid>https://orcid.org/0000-0001-8648-4998</orcidid><orcidid>https://orcid.org/0000-0002-1683-7265</orcidid><orcidid>https://orcid.org/0000-0001-6003-7794</orcidid><orcidid>https://orcid.org/0000-0002-6426-1969</orcidid></search><sort><creationdate>20241130</creationdate><title>Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study</title><author>Noh, Hwayoung ; Lee, Jeeyoo ; Seyed Khoei, Nazlisadat ; Peruchet-Noray, Laia ; Kang, Daehee ; Fervers, Beatrice ; Wagner, Karl-Heinz ; Shin, Aesun ; Freisling, Heinz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-8b11d53ede8e6faac48eed9e749f83d8aeb667dba8b1151b70a5042a233059793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/499</topic><topic>692/699/67/2324</topic><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Bilirubin</topic><topic>Bilirubin - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gender differences</topic><topic>Genomes</topic><topic>Health risks</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk Factors</topic><topic>Sex differences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noh, Hwayoung</creatorcontrib><creatorcontrib>Lee, Jeeyoo</creatorcontrib><creatorcontrib>Seyed Khoei, Nazlisadat</creatorcontrib><creatorcontrib>Peruchet-Noray, Laia</creatorcontrib><creatorcontrib>Kang, Daehee</creatorcontrib><creatorcontrib>Fervers, Beatrice</creatorcontrib><creatorcontrib>Wagner, Karl-Heinz</creatorcontrib><creatorcontrib>Shin, Aesun</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noh, Hwayoung</au><au>Lee, Jeeyoo</au><au>Seyed Khoei, Nazlisadat</au><au>Peruchet-Noray, Laia</au><au>Kang, Daehee</au><au>Fervers, Beatrice</au><au>Wagner, Karl-Heinz</au><au>Shin, Aesun</au><au>Freisling, Heinz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2024-11-30</date><risdate>2024</risdate><volume>131</volume><issue>10</issue><spage>1635</spage><epage>1643</epage><pages>1635-1643</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><abstract>Background
Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent.
Methods
In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CRC risk in 78,467 Korean adults aged 40–78 years at recruitment, considering potential non-linearity and sex differences. Hazard ratios (HR) and 95% confidence intervals (CI) for associations with CRC risk were estimated with Cox proportional hazard regression.
Results
During a median 7.9-year follow-up, 539 incident CRC cases were recorded. In multivariable-adjusted models, higher levels of total bilirubin were associated with a 26% (CI: 42% to 7%) lower risk of CRC among men and women combined, comparing the highest with the lowest tertile (
P
-linear trend = 0.003). A U-shaped association was observed in men, with the lowest risk at approximately 0.8 mg/dL (=13.7 μmol/L) of total bilirubin (
P
for non-linearity = 0.01). Although the association was largely null in women, there was no evidence for effect modification by sex (
P
-interaction = 0.73). Associations between indirect bilirubin and CRC risk were similar.
Conclusions
Higher circulating levels of total and indirect bilirubin were inversely associated with the risk of CRC among Korean adults. The associations were strongly inverse and U-shaped among men.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>39379570</pmid><doi>10.1038/s41416-024-02847-9</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8742-8920</orcidid><orcidid>https://orcid.org/0000-0001-8648-4998</orcidid><orcidid>https://orcid.org/0000-0002-1683-7265</orcidid><orcidid>https://orcid.org/0000-0001-6003-7794</orcidid><orcidid>https://orcid.org/0000-0002-6426-1969</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2024-11, Vol.131 (10), p.1635-1643 |
| issn | 0007-0920 1532-1827 1532-1827 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3114499677 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 692/499 692/699/67/2324 Adult Adults Aged Bilirubin Bilirubin - blood Biomedical and Life Sciences Biomedicine Cancer Research Cohort analysis Cohort Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - epidemiology Drug Resistance Epidemiology Female Gender differences Genomes Health risks Humans Male Middle Aged Molecular Medicine Oncology Proportional Hazards Models Prospective Studies Republic of Korea - epidemiology Risk Factors Sex differences |
| title | Serum bilirubin levels and risk of colorectal cancer in Korean adults: results from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) Cohort Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T08%3A54%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20bilirubin%20levels%20and%20risk%20of%20colorectal%20cancer%20in%20Korean%20adults:%20results%20from%20the%20Korean%20Genome%20and%20Epidemiology%20Study-Health%20Examinee%20(KoGES-HEXA)%20Cohort%20Study&rft.jtitle=British%20journal%20of%20cancer&rft.au=Noh,%20Hwayoung&rft.date=2024-11-30&rft.volume=131&rft.issue=10&rft.spage=1635&rft.epage=1643&rft.pages=1635-1643&rft.issn=0007-0920&rft.eissn=1532-1827&rft_id=info:doi/10.1038/s41416-024-02847-9&rft_dat=%3Cproquest_cross%3E3126812974%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3126812974&rft_id=info:pmid/39379570&rfr_iscdi=true |