Crosstalk between mitochondria–ER contact sites and the apoptotic machinery as a novel health meter

Mitochondria–endoplasmic reticulum (ER) contact sites (MERCS) are signaling hubs that are involved in vital cellular processes such as calcium signaling, lipid metabolism, autophagy, and apoptosis.Alterations in MERCS dynamics and composition are closely associated with severe human diseases such as...

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Veröffentlicht in:	Trends in cell biology 2025-01, Vol.35 (1), p.33-45
Hauptverfasser:	Larrañaga-SanMiguel, Alvaro, Bengoa-Vergniory, Nora, Flores-Romero, Hector
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis cancer Endoplasmic Reticulum - metabolism Humans inflammation MAMs MERCS Mitochondria - metabolism Mitochondria Associated Membranes neurodegeneration Proto-Oncogene Proteins c-bcl-2 - metabolism Signal Transduction
Online-Zugang:	Volltext
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