Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons

•Greater neighborhood ethnoracial diversity was associated with reduced positive symptoms.•Peer victimization and ethnoracial discrimination partly mediated this association.•These findings may help develop effective interventions to prevent psychosis. Neighborhood ethnoracial composition has been a...

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Veröffentlicht in:Psychiatry research 2024-12, Vol.342, p.116222, Article 116222
Hauptverfasser: Ku, Benson S., Yuan, Qingyue, Haardörfer, Regine, Addington, Jean, Bearden, Carrie E., Cadenhead, Kristin S., Cannon, Tyrone D., Cornblatt, Barbara A., Keshavan, Matcheri, Mathalon, Daniel H., Perkins, Diana O., Stone, William, Woods, Scott W., Druss, Benjamin G., Walker, Elaine, Anglin, Deidre M.
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container_issue
container_start_page 116222
container_title Psychiatry research
container_volume 342
creator Ku, Benson S.
Yuan, Qingyue
Haardörfer, Regine
Addington, Jean
Bearden, Carrie E.
Cadenhead, Kristin S.
Cannon, Tyrone D.
Cornblatt, Barbara A.
Keshavan, Matcheri
Mathalon, Daniel H.
Perkins, Diana O.
Stone, William
Woods, Scott W.
Druss, Benjamin G.
Walker, Elaine
Anglin, Deidre M.
description •Greater neighborhood ethnoracial diversity was associated with reduced positive symptoms.•Peer victimization and ethnoracial discrimination partly mediated this association.•These findings may help develop effective interventions to prevent psychosis. Neighborhood ethnoracial composition has been associated with schizophrenia, but mechanisms are unclear. This study investigates the moderators and mediators of the association between neighborhood ethnoracial diversity and positive symptoms among youth at clinical high-risk for psychosis (CHR-P) and healthy comparisons (HC). Data were collected as part of The North American Prodrome Longitudinal Study and included 492 youth at CHR-P and 136 HCs. Neighborhood ethnoracial diversity measures the probability that two people chosen at random will be from different ethnoracial groups. Attenuated positive symptoms were derived from the Scale of Prodromal Symptoms. Peer victimization and discriminatory experiences were constructed as latent variables. Using structural equation modeling, this study tested the relationship of these variables and included the following covariates: age, sex, neighborhood poverty, and depressive symptoms. Greater neighborhood ethnoracial diversity was associated with reduced positive symptoms among ethnoracial minorities at CHR-P (β=-3.78; 95 % CI [-6.61, -0.84]). Fewer life events of peer victimization (β=-0.13; 95 % CI [-0.24, -0.03]) leading to perceived ethnoracial discrimination (β=0.56; 95 % CI [0.45, 0.67]) mediated 15.06 % of this association. These findings deepen our understanding of the social determinants of psychosis and may help develop effective interventions to prevent psychosis, especially among ethnoracial minority youth at high risk.
doi_str_mv 10.1016/j.psychres.2024.116222
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Neighborhood ethnoracial composition has been associated with schizophrenia, but mechanisms are unclear. This study investigates the moderators and mediators of the association between neighborhood ethnoracial diversity and positive symptoms among youth at clinical high-risk for psychosis (CHR-P) and healthy comparisons (HC). Data were collected as part of The North American Prodrome Longitudinal Study and included 492 youth at CHR-P and 136 HCs. Neighborhood ethnoracial diversity measures the probability that two people chosen at random will be from different ethnoracial groups. Attenuated positive symptoms were derived from the Scale of Prodromal Symptoms. Peer victimization and discriminatory experiences were constructed as latent variables. Using structural equation modeling, this study tested the relationship of these variables and included the following covariates: age, sex, neighborhood poverty, and depressive symptoms. 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subjects Adolescent
Bullying - statistics & numerical data
Clinical high risk for psychosis
Cultural Diversity
Discrimination
Ethnicity - psychology
Ethnoracial diversity
Female
Humans
Longitudinal Studies
Male
Neighborhood Characteristics
Peer Group
Peer victimization
Prodromal Symptoms
Psychotic Disorders - ethnology
Psychotic symptoms
Racial Groups - psychology
Social determinants of health
Young Adult
title Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
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