Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway

•28 compounds were detected in the DBD-treated plasma under a pathological state.•DBD can modulate the AGEs/RAGE pathway to reduce renal oxidative stress.•DBD can regulate carbonyl compounds metabolic profile to inhibit renal injury.•Seven main components with the potential to improve DN were screen...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-12, Vol.135, p.156104, Article 156104
Hauptverfasser:	Zhang, Zhi-Tong, Qi, Yali, Chen, Pan, Chen, Li, Jiang, Yue, Fan, Zhiliang, Guan, Huanhuan, Bai, Lei, Liu, Jie, Zhao, Di, Yan, Guojun
Format:	Artikel
Sprache:	eng
Schlagworte:	AGEs/RAGE pathway Animals Blood Glucose - drug effects Carbonyl compounds Dang-Gui-Bu-Xue decoction Diabetes Mellitus, Experimental - drug therapy Diabetic Nephropathies - drug therapy Diabetic nephropathy Diet, High-Fat - adverse effects Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Glycation End Products, Advanced - metabolism Kidney - drug effects Male Mice Mice, Inbred C57BL Network Pharmacology Receptor for Advanced Glycation End Products - metabolism Streptozocin Tandem Mass Spectrometry
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