Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention
This 24‐week single‐blind trial tested a modular approach for young autistic children (MAYAC) that was delivered for fewer hours per week and modified based on child progress and parental input compared to comprehensive behavioral intervention treatment as usual (CBI, TAU). Participants were autisti...
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| Veröffentlicht in: | Autism research 2024-11, Vol.17 (11), p.2430-2446 |
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| creator | Anderson, Cynthia Hochheimer, Samantha Warren, Zachary Butter, Eric Hyman, Susan L. Wang, Hongyue Wallace, Lisa Levato, Lynne Martin, Ryan Stephenson, Kevin G. Norris, Megan Jacqueline, Wynn Smith, Tristram Johnson, Cynthia R. |
| description | This 24‐week single‐blind trial tested a modular approach for young autistic children (MAYAC) that was delivered for fewer hours per week and modified based on child progress and parental input compared to comprehensive behavioral intervention treatment as usual (CBI, TAU). Participants were autistic children, ages 18–60 months of age. MAYAC was initially 5 h of intervention per week, one of which was parent training and the other four direct therapy focusing on social communication and engagement, but additional modules could be added for up to 10 h per week. Comprehensive behavior intervention was delivered for ≥15 h per week. Outcome measures included the Vineland Adaptive Behavior Scales; VABS, the Ohio Autism Clinical Improvement Scale – Autism Severity; OACIS – AS and the Pervasive Developmental Disorder Behavior Inventory – Parent; PDDBI‐P. Implementation and parent satisfaction measures were also collected. Fifty‐six children, mean age of 34 months, were randomized. Within‐group analysis revealed significant improvements from baseline to week 24 for both MAYAC (p |
| doi_str_mv | 10.1002/aur.3240 |
| format | Article |
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Lay Summary
In a 24‐week randomized control trial, we tested a modular approach for young autistic children of a lower dose with modifications made based on the child's progress compared to a comprehensive behavioral intervention of more hours. Fifty‐six young children with autism, ages 18–60 months received either the modular approach or the comprehensive behavior intervention. The two approaches were comparable in improving adaptive behaviors and overall autism severity. The findings of this small trial suggest a modular, less intensive approach may be an alternative for some young autistic children and their families to more traditional comprehensive behavior intervention treatment.</description><identifier>ISSN: 1939-3792</identifier><identifier>ISSN: 1939-3806</identifier><identifier>EISSN: 1939-3806</identifier><identifier>DOI: 10.1002/aur.3240</identifier><identifier>PMID: 39375937</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Age ; applied behavior analysis ; Autism ; Autism Spectrum Disorder - therapy ; Autistic children ; Autistic Disorder - therapy ; Behavior modification ; Behavior Therapy - methods ; behavioral intervention ; Child, Preschool ; Children ; comprehensive behavior intervention (CBI) ; discrete trial training (DTT) ; early intensive Behavioral intervention (EIBI) ; Female ; Humans ; Infant ; Male ; naturalistic developmental Behavioral interventions (NDBIs) ; noninferiority design ; Parental behavior ; Parents ; randomized clinical trial (RCT) ; Single-Blind Method ; Social behavior ; Treatment Outcome</subject><ispartof>Autism research, 2024-11, Vol.17 (11), p.2430-2446</ispartof><rights>2024 The Author(s). published by International Society for Autism Research and Wiley Periodicals LLC.</rights><rights>2024 The Author(s). Autism Research published by International Society for Autism Research and Wiley Periodicals LLC.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2740-71015858b4bd767064de7e86a48fce11ed3ed23c24d8d276f825d9cc1a864bb33</cites><orcidid>0000-0002-5196-9407 ; 0000-0002-1395-6779</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Faur.3240$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Faur.3240$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39375937$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Cynthia</creatorcontrib><creatorcontrib>Hochheimer, Samantha</creatorcontrib><creatorcontrib>Warren, Zachary</creatorcontrib><creatorcontrib>Butter, Eric</creatorcontrib><creatorcontrib>Hyman, Susan L.</creatorcontrib><creatorcontrib>Wang, Hongyue</creatorcontrib><creatorcontrib>Wallace, Lisa</creatorcontrib><creatorcontrib>Levato, Lynne</creatorcontrib><creatorcontrib>Martin, Ryan</creatorcontrib><creatorcontrib>Stephenson, Kevin G.</creatorcontrib><creatorcontrib>Norris, Megan</creatorcontrib><creatorcontrib>Jacqueline, Wynn</creatorcontrib><creatorcontrib>Smith, Tristram</creatorcontrib><creatorcontrib>Johnson, Cynthia R.</creatorcontrib><title>Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention</title><title>Autism research</title><addtitle>Autism Res</addtitle><description>This 24‐week single‐blind trial tested a modular approach for young autistic children (MAYAC) that was delivered for fewer hours per week and modified based on child progress and parental input compared to comprehensive behavioral intervention treatment as usual (CBI, TAU). Participants were autistic children, ages 18–60 months of age. MAYAC was initially 5 h of intervention per week, one of which was parent training and the other four direct therapy focusing on social communication and engagement, but additional modules could be added for up to 10 h per week. Comprehensive behavior intervention was delivered for ≥15 h per week. Outcome measures included the Vineland Adaptive Behavior Scales; VABS, the Ohio Autism Clinical Improvement Scale – Autism Severity; OACIS – AS and the Pervasive Developmental Disorder Behavior Inventory – Parent; PDDBI‐P. Implementation and parent satisfaction measures were also collected. Fifty‐six children, mean age of 34 months, were randomized. Within‐group analysis revealed significant improvements from baseline to week 24 for both MAYAC (p < 0.0001) and CBI, TAU (p < 0.0001) on the VABS. The noninferiority test was performed to test between group differences and MAYAC was not inferior to CBI, TAU on the VABS (p = 0.0144). On the OACIS – AS, 48.0% of MAYAC and 45.5% of CBI were treatment responders there were no significant changes on the PDDBI‐P, for either group. Treatment fidelity was high for both groups (>95%) as was parent satisfaction. Findings from this small trial are promising and suggest MAYAC may be an alternative for some young autistic children and their families to CBI, TAU.
Lay Summary
In a 24‐week randomized control trial, we tested a modular approach for young autistic children of a lower dose with modifications made based on the child's progress compared to a comprehensive behavioral intervention of more hours. Fifty‐six young children with autism, ages 18–60 months received either the modular approach or the comprehensive behavior intervention. The two approaches were comparable in improving adaptive behaviors and overall autism severity. The findings of this small trial suggest a modular, less intensive approach may be an alternative for some young autistic children and their families to more traditional comprehensive behavior intervention treatment.</description><subject>Age</subject><subject>applied behavior analysis</subject><subject>Autism</subject><subject>Autism Spectrum Disorder - therapy</subject><subject>Autistic children</subject><subject>Autistic Disorder - therapy</subject><subject>Behavior modification</subject><subject>Behavior Therapy - methods</subject><subject>behavioral intervention</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>comprehensive behavior intervention (CBI)</subject><subject>discrete trial training (DTT)</subject><subject>early intensive Behavioral intervention (EIBI)</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>naturalistic developmental Behavioral interventions (NDBIs)</subject><subject>noninferiority design</subject><subject>Parental behavior</subject><subject>Parents</subject><subject>randomized clinical trial (RCT)</subject><subject>Single-Blind Method</subject><subject>Social behavior</subject><subject>Treatment Outcome</subject><issn>1939-3792</issn><issn>1939-3806</issn><issn>1939-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctKxDAUhoMoOl7AJ5CAGzfV3Nqm7obBG4wI4qxLmpw6kU4zJq0yb-Bjm7kpCC5C_sDHd074ETql5JISwq5U7y85E2QHDWjBi4RLku1uc16wA3QYwhshGeEp20cHvOB5Gs8AfY3cbK686uwHYKhr0MvUQgi481Y11_jRmb5RHlcwVR_Weazmc--UnuI6Phaub1-x6jsbOquxntrGeGixXmnB4M6tsocptGE5ZOtRDbZtBz5O66xrj9FerZoAJ5v7CE1ub15G98n46e5hNBwnmuWCJDklNJWprERl8iwnmTCQg8yUkLUGSsFwMIxrJow0LM9qyVJTaE2VzERVcX6ELtbe-In3HkJXzmzQ0DSqBdeHklMqaMoySiN6_gd9c71v43aRYrKgnHHxK9TeheChLufezpRflJSUy3bK2E65bCeiZxthX83A_IDbOiKQrIFP28DiX1E5nDyvhN8tC5ua</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Anderson, Cynthia</creator><creator>Hochheimer, Samantha</creator><creator>Warren, Zachary</creator><creator>Butter, Eric</creator><creator>Hyman, Susan L.</creator><creator>Wang, Hongyue</creator><creator>Wallace, Lisa</creator><creator>Levato, Lynne</creator><creator>Martin, Ryan</creator><creator>Stephenson, Kevin G.</creator><creator>Norris, Megan</creator><creator>Jacqueline, Wynn</creator><creator>Smith, Tristram</creator><creator>Johnson, Cynthia R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5196-9407</orcidid><orcidid>https://orcid.org/0000-0002-1395-6779</orcidid></search><sort><creationdate>202411</creationdate><title>Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention</title><author>Anderson, Cynthia ; Hochheimer, Samantha ; Warren, Zachary ; Butter, Eric ; Hyman, Susan L. ; Wang, Hongyue ; Wallace, Lisa ; Levato, Lynne ; Martin, Ryan ; Stephenson, Kevin G. ; Norris, Megan ; Jacqueline, Wynn ; Smith, Tristram ; Johnson, Cynthia R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2740-71015858b4bd767064de7e86a48fce11ed3ed23c24d8d276f825d9cc1a864bb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age</topic><topic>applied behavior analysis</topic><topic>Autism</topic><topic>Autism Spectrum Disorder - therapy</topic><topic>Autistic children</topic><topic>Autistic Disorder - therapy</topic><topic>Behavior modification</topic><topic>Behavior Therapy - methods</topic><topic>behavioral intervention</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>comprehensive behavior intervention (CBI)</topic><topic>discrete trial training (DTT)</topic><topic>early intensive Behavioral intervention (EIBI)</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>naturalistic developmental Behavioral interventions (NDBIs)</topic><topic>noninferiority design</topic><topic>Parental behavior</topic><topic>Parents</topic><topic>randomized clinical trial (RCT)</topic><topic>Single-Blind Method</topic><topic>Social behavior</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Cynthia</creatorcontrib><creatorcontrib>Hochheimer, Samantha</creatorcontrib><creatorcontrib>Warren, Zachary</creatorcontrib><creatorcontrib>Butter, Eric</creatorcontrib><creatorcontrib>Hyman, Susan L.</creatorcontrib><creatorcontrib>Wang, Hongyue</creatorcontrib><creatorcontrib>Wallace, Lisa</creatorcontrib><creatorcontrib>Levato, Lynne</creatorcontrib><creatorcontrib>Martin, Ryan</creatorcontrib><creatorcontrib>Stephenson, Kevin G.</creatorcontrib><creatorcontrib>Norris, Megan</creatorcontrib><creatorcontrib>Jacqueline, Wynn</creatorcontrib><creatorcontrib>Smith, Tristram</creatorcontrib><creatorcontrib>Johnson, Cynthia R.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Autism research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Cynthia</au><au>Hochheimer, Samantha</au><au>Warren, Zachary</au><au>Butter, Eric</au><au>Hyman, Susan L.</au><au>Wang, Hongyue</au><au>Wallace, Lisa</au><au>Levato, Lynne</au><au>Martin, Ryan</au><au>Stephenson, Kevin G.</au><au>Norris, Megan</au><au>Jacqueline, Wynn</au><au>Smith, Tristram</au><au>Johnson, Cynthia R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention</atitle><jtitle>Autism research</jtitle><addtitle>Autism Res</addtitle><date>2024-11</date><risdate>2024</risdate><volume>17</volume><issue>11</issue><spage>2430</spage><epage>2446</epage><pages>2430-2446</pages><issn>1939-3792</issn><issn>1939-3806</issn><eissn>1939-3806</eissn><abstract>This 24‐week single‐blind trial tested a modular approach for young autistic children (MAYAC) that was delivered for fewer hours per week and modified based on child progress and parental input compared to comprehensive behavioral intervention treatment as usual (CBI, TAU). Participants were autistic children, ages 18–60 months of age. MAYAC was initially 5 h of intervention per week, one of which was parent training and the other four direct therapy focusing on social communication and engagement, but additional modules could be added for up to 10 h per week. Comprehensive behavior intervention was delivered for ≥15 h per week. Outcome measures included the Vineland Adaptive Behavior Scales; VABS, the Ohio Autism Clinical Improvement Scale – Autism Severity; OACIS – AS and the Pervasive Developmental Disorder Behavior Inventory – Parent; PDDBI‐P. Implementation and parent satisfaction measures were also collected. Fifty‐six children, mean age of 34 months, were randomized. Within‐group analysis revealed significant improvements from baseline to week 24 for both MAYAC (p < 0.0001) and CBI, TAU (p < 0.0001) on the VABS. The noninferiority test was performed to test between group differences and MAYAC was not inferior to CBI, TAU on the VABS (p = 0.0144). On the OACIS – AS, 48.0% of MAYAC and 45.5% of CBI were treatment responders there were no significant changes on the PDDBI‐P, for either group. Treatment fidelity was high for both groups (>95%) as was parent satisfaction. Findings from this small trial are promising and suggest MAYAC may be an alternative for some young autistic children and their families to CBI, TAU.
Lay Summary
In a 24‐week randomized control trial, we tested a modular approach for young autistic children of a lower dose with modifications made based on the child's progress compared to a comprehensive behavioral intervention of more hours. Fifty‐six young children with autism, ages 18–60 months received either the modular approach or the comprehensive behavior intervention. The two approaches were comparable in improving adaptive behaviors and overall autism severity. The findings of this small trial suggest a modular, less intensive approach may be an alternative for some young autistic children and their families to more traditional comprehensive behavior intervention treatment.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>39375937</pmid><doi>10.1002/aur.3240</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-5196-9407</orcidid><orcidid>https://orcid.org/0000-0002-1395-6779</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age applied behavior analysis Autism Autism Spectrum Disorder - therapy Autistic children Autistic Disorder - therapy Behavior modification Behavior Therapy - methods behavioral intervention Child, Preschool Children comprehensive behavior intervention (CBI) discrete trial training (DTT) early intensive Behavioral intervention (EIBI) Female Humans Infant Male naturalistic developmental Behavioral interventions (NDBIs) noninferiority design Parental behavior Parents randomized clinical trial (RCT) Single-Blind Method Social behavior Treatment Outcome |
| title | Comparative effectiveness trial: Modular behavior approach for young autistic children compared to comprehensive behavioral intervention |
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