Macrophage MAPK7/AhR/STAT3 Signaling Mediates Mitochondrial ROS Burst and Enterohepatic Inflammatory Responses Induced by Deoxynivalenol Relevant to Low-Dose Exposure in Children

Deoxynivalenol (DON) can induce endoplasmic reticulum (ER) stress, mitochondrial ROS burst, and macrophage polarization. Here, we investigated the mechanism linking the above three aspects with the dose range relevant to low-level exposure in children. At 0.5 μg/kg bw/day, we found remarkable liver...

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Veröffentlicht in:	Environmental science & technology 2024-10, Vol.58 (42), p.18589-18602
Hauptverfasser:	Zhang, Qi, Liu, Ming, Zhang, Jing, Jiang, Huiyu, Ma, Chuanmin, Jian, Yuanzhi, Chen, Yongchang, Liu, Hui, Chen, Hanri, Chen, Jiaqi, Sun, Xiulan, Wang, Jia-Sheng, Zhao, Xiulan, Geng, Xingyi, Song, Fuyong, Zhou, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Children Deoxynivalenol Docks Ecotoxicology and Public Health Endoplasmic reticulum Exposure Health risks Inflammation Liver Macrophages Mitochondria Oligomerization Polarization Population studies Stat3 protein Toxicity
Online-Zugang:	Volltext
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