Three New Antibacterial Mycophenolic Acid Derivatives from the Marine‐Derived Fungus Penicillium sp. HN‐66
Three new mycophenolic acid derivatives, penicacids L−N (1–3), together with four known analogues, were isolated from a fungus Penicillium sp. HN‐66 derived from a South China Sea marine sediment. The structures of compounds 1–3 were determined on the basis of HR‐ESI‐MS, NMR (1H, 13C, HSQC and HMBC)...
Gespeichert in:
| Veröffentlicht in: | Chemistry & biodiversity 2025-01, Vol.22 (1), p.e202401657-n/a |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 1 |
| container_start_page | e202401657 |
| container_title | Chemistry & biodiversity |
| container_volume | 22 |
| creator | Mo, TuXiang Qin, YuYue Zhang, Yue Liang, YongBin Li, XiaoBao Li, WanShan Chen, GuangYing |
| description | Three new mycophenolic acid derivatives, penicacids L−N (1–3), together with four known analogues, were isolated from a fungus Penicillium sp. HN‐66 derived from a South China Sea marine sediment. The structures of compounds 1–3 were determined on the basis of HR‐ESI‐MS, NMR (1H, 13C, HSQC and HMBC) data analyses, and comparison of optical rotations. Antimicrobial activities of 1–7 were tested. The results showed that compounds 1–3 and 5–7 had weak inhibitory effects against E. coli ATCC 25922 with the MIC values of 50 μg/mL. |
| doi_str_mv | 10.1002/cbdv.202401657 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3114150890</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3114150890</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2587-9e533a2d447a459c4e15ca9c8fb43a365ebd86042305496528ce25f800c5f71c3</originalsourceid><addsrcrecordid>eNqFkblOAzEQhi0E4gi0lMgSDU2Cz11vGcIphaMA2pXXO0uM9gj2blA6HoFn5EkwJASJhmpGM9_8M5ofoX1KBpQQdmyyfDZghAlCIxmvoW0aUdanSpH1VR6zLbTj_XPgQ11toi2e8FhKybdRfT9xAPgGXvGwbm2mTQvO6hJfz00znUDdlNbgobE5Pg2NmW7tDDwuXFPhdgL4Wjtbw8fb-3cXcnze1U-dx3dQW2PL0nYV9tMBvrwJTBTtoo1Clx72lrGHHs7P7keX_fHtxdVoOO4bJlXcT0ByrlkuRKyFTIwAKo1OjCoywTWPJGS5iohgnEiRRJIpA0wWihAji5ga3kNHC92pa1468G1aWW-gLHUNTedTTqmgkqiEBPTwD_rcdK4O1wVKRuEQFfb00GBBGdd476BIp85W2s1TStIvJ9IvJ9KVE2HgYCnbZRXkK_zn9QFIFsCrLWH-j1w6Ojl9_BX_BAjulXE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3156533842</pqid></control><display><type>article</type><title>Three New Antibacterial Mycophenolic Acid Derivatives from the Marine‐Derived Fungus Penicillium sp. HN‐66</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Mo, TuXiang ; Qin, YuYue ; Zhang, Yue ; Liang, YongBin ; Li, XiaoBao ; Li, WanShan ; Chen, GuangYing</creator><creatorcontrib>Mo, TuXiang ; Qin, YuYue ; Zhang, Yue ; Liang, YongBin ; Li, XiaoBao ; Li, WanShan ; Chen, GuangYing</creatorcontrib><description>Three new mycophenolic acid derivatives, penicacids L−N (1–3), together with four known analogues, were isolated from a fungus Penicillium sp. HN‐66 derived from a South China Sea marine sediment. The structures of compounds 1–3 were determined on the basis of HR‐ESI‐MS, NMR (1H, 13C, HSQC and HMBC) data analyses, and comparison of optical rotations. Antimicrobial activities of 1–7 were tested. The results showed that compounds 1–3 and 5–7 had weak inhibitory effects against E. coli ATCC 25922 with the MIC values of 50 μg/mL.</description><identifier>ISSN: 1612-1872</identifier><identifier>ISSN: 1612-1880</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.202401657</identifier><identifier>PMID: 39375553</identifier><language>eng</language><publisher>Switzerland: Wiley Subscription Services, Inc</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial activity ; Antiinfectives and antibacterials ; Chemical constituents ; E coli ; Escherichia coli - drug effects ; Fungi ; Marine sediments ; Marine-derived fungi ; Microbial Sensitivity Tests ; Molecular Conformation ; Molecular Structure ; Mycophenolic acid ; Mycophenolic Acid - chemistry ; Mycophenolic Acid - isolation & purification ; Mycophenolic Acid - pharmacology ; Mycophenolic acid derivatives ; NMR ; Nuclear magnetic resonance ; Penicillium ; Penicillium - chemistry ; Penicillium sp</subject><ispartof>Chemistry & biodiversity, 2025-01, Vol.22 (1), p.e202401657-n/a</ispartof><rights>2024 Wiley-VHCA AG, Zurich, Switzerland</rights><rights>2024 Wiley-VHCA AG, Zurich, Switzerland.</rights><rights>2025 Wiley-VHCA AG, Zurich, Switzerland</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2587-9e533a2d447a459c4e15ca9c8fb43a365ebd86042305496528ce25f800c5f71c3</cites><orcidid>0000-0002-6729-0597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.202401657$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.202401657$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39375553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mo, TuXiang</creatorcontrib><creatorcontrib>Qin, YuYue</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Liang, YongBin</creatorcontrib><creatorcontrib>Li, XiaoBao</creatorcontrib><creatorcontrib>Li, WanShan</creatorcontrib><creatorcontrib>Chen, GuangYing</creatorcontrib><title>Three New Antibacterial Mycophenolic Acid Derivatives from the Marine‐Derived Fungus Penicillium sp. HN‐66</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>Three new mycophenolic acid derivatives, penicacids L−N (1–3), together with four known analogues, were isolated from a fungus Penicillium sp. HN‐66 derived from a South China Sea marine sediment. The structures of compounds 1–3 were determined on the basis of HR‐ESI‐MS, NMR (1H, 13C, HSQC and HMBC) data analyses, and comparison of optical rotations. Antimicrobial activities of 1–7 were tested. The results showed that compounds 1–3 and 5–7 had weak inhibitory effects against E. coli ATCC 25922 with the MIC values of 50 μg/mL.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial activity</subject><subject>Antiinfectives and antibacterials</subject><subject>Chemical constituents</subject><subject>E coli</subject><subject>Escherichia coli - drug effects</subject><subject>Fungi</subject><subject>Marine sediments</subject><subject>Marine-derived fungi</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Conformation</subject><subject>Molecular Structure</subject><subject>Mycophenolic acid</subject><subject>Mycophenolic Acid - chemistry</subject><subject>Mycophenolic Acid - isolation & purification</subject><subject>Mycophenolic Acid - pharmacology</subject><subject>Mycophenolic acid derivatives</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Penicillium</subject><subject>Penicillium - chemistry</subject><subject>Penicillium sp</subject><issn>1612-1872</issn><issn>1612-1880</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkblOAzEQhi0E4gi0lMgSDU2Cz11vGcIphaMA2pXXO0uM9gj2blA6HoFn5EkwJASJhmpGM9_8M5ofoX1KBpQQdmyyfDZghAlCIxmvoW0aUdanSpH1VR6zLbTj_XPgQ11toi2e8FhKybdRfT9xAPgGXvGwbm2mTQvO6hJfz00znUDdlNbgobE5Pg2NmW7tDDwuXFPhdgL4Wjtbw8fb-3cXcnze1U-dx3dQW2PL0nYV9tMBvrwJTBTtoo1Clx72lrGHHs7P7keX_fHtxdVoOO4bJlXcT0ByrlkuRKyFTIwAKo1OjCoywTWPJGS5iohgnEiRRJIpA0wWihAji5ga3kNHC92pa1468G1aWW-gLHUNTedTTqmgkqiEBPTwD_rcdK4O1wVKRuEQFfb00GBBGdd476BIp85W2s1TStIvJ9IvJ9KVE2HgYCnbZRXkK_zn9QFIFsCrLWH-j1w6Ojl9_BX_BAjulXE</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Mo, TuXiang</creator><creator>Qin, YuYue</creator><creator>Zhang, Yue</creator><creator>Liang, YongBin</creator><creator>Li, XiaoBao</creator><creator>Li, WanShan</creator><creator>Chen, GuangYing</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6729-0597</orcidid></search><sort><creationdate>202501</creationdate><title>Three New Antibacterial Mycophenolic Acid Derivatives from the Marine‐Derived Fungus Penicillium sp. HN‐66</title><author>Mo, TuXiang ; Qin, YuYue ; Zhang, Yue ; Liang, YongBin ; Li, XiaoBao ; Li, WanShan ; Chen, GuangYing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2587-9e533a2d447a459c4e15ca9c8fb43a365ebd86042305496528ce25f800c5f71c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial activity</topic><topic>Antiinfectives and antibacterials</topic><topic>Chemical constituents</topic><topic>E coli</topic><topic>Escherichia coli - drug effects</topic><topic>Fungi</topic><topic>Marine sediments</topic><topic>Marine-derived fungi</topic><topic>Microbial Sensitivity Tests</topic><topic>Molecular Conformation</topic><topic>Molecular Structure</topic><topic>Mycophenolic acid</topic><topic>Mycophenolic Acid - chemistry</topic><topic>Mycophenolic Acid - isolation & purification</topic><topic>Mycophenolic Acid - pharmacology</topic><topic>Mycophenolic acid derivatives</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Penicillium</topic><topic>Penicillium - chemistry</topic><topic>Penicillium sp</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mo, TuXiang</creatorcontrib><creatorcontrib>Qin, YuYue</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Liang, YongBin</creatorcontrib><creatorcontrib>Li, XiaoBao</creatorcontrib><creatorcontrib>Li, WanShan</creatorcontrib><creatorcontrib>Chen, GuangYing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mo, TuXiang</au><au>Qin, YuYue</au><au>Zhang, Yue</au><au>Liang, YongBin</au><au>Li, XiaoBao</au><au>Li, WanShan</au><au>Chen, GuangYing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three New Antibacterial Mycophenolic Acid Derivatives from the Marine‐Derived Fungus Penicillium sp. HN‐66</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chem Biodivers</addtitle><date>2025-01</date><risdate>2025</risdate><volume>22</volume><issue>1</issue><spage>e202401657</spage><epage>n/a</epage><pages>e202401657-n/a</pages><issn>1612-1872</issn><issn>1612-1880</issn><eissn>1612-1880</eissn><abstract>Three new mycophenolic acid derivatives, penicacids L−N (1–3), together with four known analogues, were isolated from a fungus Penicillium sp. HN‐66 derived from a South China Sea marine sediment. The structures of compounds 1–3 were determined on the basis of HR‐ESI‐MS, NMR (1H, 13C, HSQC and HMBC) data analyses, and comparison of optical rotations. Antimicrobial activities of 1–7 were tested. The results showed that compounds 1–3 and 5–7 had weak inhibitory effects against E. coli ATCC 25922 with the MIC values of 50 μg/mL.</abstract><cop>Switzerland</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39375553</pmid><doi>10.1002/cbdv.202401657</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-6729-0597</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1612-1872 |
| ispartof | Chemistry & biodiversity, 2025-01, Vol.22 (1), p.e202401657-n/a |
| issn | 1612-1872 1612-1880 1612-1880 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3114150890 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial activity Antiinfectives and antibacterials Chemical constituents E coli Escherichia coli - drug effects Fungi Marine sediments Marine-derived fungi Microbial Sensitivity Tests Molecular Conformation Molecular Structure Mycophenolic acid Mycophenolic Acid - chemistry Mycophenolic Acid - isolation & purification Mycophenolic Acid - pharmacology Mycophenolic acid derivatives NMR Nuclear magnetic resonance Penicillium Penicillium - chemistry Penicillium sp |
| title | Three New Antibacterial Mycophenolic Acid Derivatives from the Marine‐Derived Fungus Penicillium sp. HN‐66 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T06%3A13%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Three%20New%20Antibacterial%20Mycophenolic%20Acid%20Derivatives%20from%20the%20Marine%E2%80%90Derived%20Fungus%20Penicillium%20sp.%20HN%E2%80%9066&rft.jtitle=Chemistry%20&%20biodiversity&rft.au=Mo,%20TuXiang&rft.date=2025-01&rft.volume=22&rft.issue=1&rft.spage=e202401657&rft.epage=n/a&rft.pages=e202401657-n/a&rft.issn=1612-1872&rft.eissn=1612-1880&rft_id=info:doi/10.1002/cbdv.202401657&rft_dat=%3Cproquest_cross%3E3114150890%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3156533842&rft_id=info:pmid/39375553&rfr_iscdi=true |