Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer

Purpose Establishing an immunosuppressive premetastatic niche (PMN) in distant organs is crucial for breast cancer metastasis. Vascular endothelial cells (VECs) act as barriers to transendothelial cell migration. However, the immune functions of PMNs remain unclear. Tumour cell-released autophagosom...

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Veröffentlicht in:	Cellular oncology (Dordrecht) 2024-12, Vol.47 (6), p.2147-2162
Hauptverfasser:	Wang, Xu-ru, Zhou, Xiao-he, Sun, Xiao-tong, Shen, Yu-qing, Wu, Yu-yang, Wu, Cheng-dong, Zhu, Feng-jiao, Wei, Yi-ting, Chen, Jin-peng, Chen, Jing, Zheng, Shi-ya, Wang, Li-xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagosomes - metabolism Autophagy B7-H1 Antigen - metabolism Biomedical and Life Sciences Biomedicine Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Cell Line, Tumor Endothelial Cells - metabolism Endothelial Cells - pathology Female HMGB1 Protein - metabolism Humans Lung - metabolism Lung - pathology Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Mice Mice, Inbred C57BL Mice, Knockout Oncology Pathology Signal Transduction Up-Regulation - genetics
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