Binge ethanol consumption can be attenuated by systemic administration of minocycline and is associated with enhanced neuroinflammation in the central amygdala

Alcohol use disorder (AUD) has a complicated pathophysiology. Binge ethanol intoxication may produce long-lasting changes throughout extended amygdala neurocircuitry including neuroinflammation, often leading to relapse. Therefore, understanding the role of binge drinking induced neuroinflammation o...

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Veröffentlicht in:	Neuropharmacology 2025-01, Vol.262, p.110174, Article 110174
Hauptverfasser:	Schrank, Sean, Sevigny, Joshua P., Yunus, N. Ika, Vetter, Katherine R., Aguilar, Oscar D., Ily, Vivek, Valchinova, Mikaela, Keinath, Alexandra T., Sparta, Dennis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binge Drinking - drug therapy Binge ethanol drinking Central amygdala Central Amygdaloid Nucleus - drug effects Central Amygdaloid Nucleus - metabolism CX3C Chemokine Receptor 1 - genetics CX3C Chemokine Receptor 1 - metabolism Ethanol - administration & dosage Female Male Mice Mice, Inbred C57BL Mice, Transgenic Microglia Minocycline Minocycline - pharmacology Neuroinflammation Neuroinflammatory Diseases - drug therapy
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