Carbon monoxide as a negative feedback mechanism on HIF-1α in the progression of metabolic-associated fatty liver disease

Metabolic-associated fatty liver disease (MAFLD) encompasses various chronic liver conditions, yet lacks approved drugs. Hypoxia-inducible factor-1α (HIF-1α) is pivotal in MAFLD development. Our prior research highlighted the efficacy of the nano-designed carbon monoxide (CO) donor, targeting HIF-1α...

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Veröffentlicht in:	Nitric oxide 2024-12, Vol.153, p.1-12
Hauptverfasser:	Cui, Yingying, Yang, Kai, Guo, Chunyu, Xia, Zhengmei, Jiang, Benchun, Xue, Yanni, Song, Bingdong, Hu, Weirong, Zhang, Mingjie, Wei, Yanyan, Zhang, Cheng, Zhang, Shichen, Fang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon monoxide Carbon Monoxide - metabolism Carbon Monoxide - pharmacology CO–HIF-1α axis Diet, High-Fat - adverse effects Disease Progression Feedback loop Feedback, Physiological Heme Oxygenase-1 - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor-1α Male Metabolic-associated fatty liver disease Mice Mice, Inbred C57BL Non-alcoholic Fatty Liver Disease - metabolism
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