Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework

•Findings of bioenergetic abnormalities require re-conceptualization of schizophrenia.•These abnormalities are present in the brain and in the periphery at first episode.•Central and systemic impairments during the disease course need to be reconciled.•We propose that schizophrenia is a disease of i...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Psychiatry research 2024-12, Vol.342, p.116220, Article 116220
Hauptverfasser:	Sarnyai, Zoltán, Ben-Shachar, Dorit
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobic glycolysis Animals Brain - metabolism Brain and periphery Dynamic energy metabolism Energy Metabolism - physiology Glucose - metabolism Humans Mitochondrial oxidative phosphorylation Schizophrenia Schizophrenia - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!