The H3.3K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation

Histone H3.3 is frequently mutated in tumors, with the lysine 36 to methionine mutation (K36M) being a hallmark of chondroblastomas. While it is known that H3.3K36M changes the epigenetic landscape, its effects on gene expression dynamics remain unclear. Here, we use a synthetic reporter to measure...

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Veröffentlicht in:	Molecular cell 2024-10, Vol.84 (20), p.3899-3915.e7
Hauptverfasser:	Sinha, Joydeb, Nickels, Jan F., Thurm, Abby R., Ludwig, Connor H., Archibald, Bella N., Hinks, Michaela M., Wan, Jun, Fang, Dong, Bintu, Lacramioara
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Cell Line, Tumor DNA Methylation Epigenesis, Genetic Epigenetic Memory Gene Expression Regulation, Neoplastic H3.3K36M H3K36me2 H3K36me3 heterochromatin Histones - genetics Histones - metabolism Humans KRAB Lysine - metabolism Mutation NSD1 oncohistone Promoter Regions, Genetic Repressor Proteins - genetics Repressor Proteins - metabolism SETD2
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