The SIRT-1/Nrf2/HO-1 axis: Guardians of neuronal health in neurological disorders

SIRT1 (Sirtuin 1) is a NAD+-dependent deacetylase that functions through nucleoplasmic transfer and is present in nearly all mammalian tissues. SIRT1 is believed to deacetylate its protein substrates, resulting in neuroprotective actions, including reduced oxidative stress and inflammation, increase...

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Veröffentlicht in:	Behavioural brain research 2025-01, Vol.476, p.115280, Article 115280
Hauptverfasser:	Sethi, Pranshul, Mehan, Sidharth, Khan, Zuber, Maurya, Pankaj Kumar, Kumar, Nitish, Kumar, Aakash, Tiwari, Aarti, Sharma, Tarun, Das Gupta, Ghanshyam, Narula, Acharan S., Kalfin, Reni
Format:	Artikel
Sprache:	eng
Schlagworte:	HO-1 Inflammation Neurodegeneration, Neuropsychiatric disorders Nrf2 Oxidative stress SIRT1 Therapeutic interventions
Online-Zugang:	Volltext
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