How enteral nutrition modes influence nasopharyngeal carcinoma survivors with late dysphagia after radiotherapy: a randomized controlled study
Background Palliation to late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC) continues to be a challenge. Intermittent oro-esophageal tube feeding (IOE) is an emerging enteral nutrition mode that can address nutrition and quality of life issues related to nasogastric tube feeding (N...
Gespeichert in:
| Veröffentlicht in: | Supportive care in cancer 2024-10, Vol.32 (10), p.702, Article 702 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 702 |
| container_title | Supportive care in cancer |
| container_volume | 32 |
| creator | Zeng, Hongji Zhao, Weijia Zhang, Xuyang Wang, Xin’ao Luo, Pengchao Li, Heping Wang, Liugen Zeng, Xi |
| description | Background
Palliation to late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC) continues to be a challenge. Intermittent oro-esophageal tube feeding (IOE) is an emerging enteral nutrition mode that can address nutrition and quality of life issues related to nasogastric tube feeding (NGT).
Objectives
This study aims to investigate the effect of IOE versus NGT in late dysphagia after radiotherapy for NPC.
Methods
This randomized controlled study included 82 NPC survivors with late dysphagia after radiotherapy. The subjects were randomized divided into the IOE and NGT groups (
n
1 =
n
2 = 41). Both groups received standard-of-care rehabilitation. Enteral nutrition supports were administered through IOE or NGT accordingly. This study lasted 2 weeks for each participant. The primary outcome was nutritional status including albumin, hemoglobin, total serum protein, and body mass index. The secondary outcomes were (i) the functional oral intake scale (FOIS), (ii) the penetration-aspiration scale (PAS), (iii) oral transit time (OTT), (iv) hyoid pause time (HPT), (v) pharyngeal transport time (PTT), and (vi) swallowing-quality of life (SWAL-QoL).
Results
Three cases quitted the study halfway and there were no significant baseline differences between the IOE (
n
= 40) and NGT (
n
= 39) groups. Both time and group effects were significant in all nutritional indicators. The time effect was significant in the FOIS levels, OTT and PTT, while the group effect was not. Either time or group effect were insignificant in the PAS levels and HPT. Both group and time effects were significant in the SWAL-QoL total scores (
z
Group
= 5.080,
P
|
| doi_str_mv | 10.1007/s00520-024-08912-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3113126102</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3113126102</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-3d24275c3e5a1f294cd9c1d9529ee9fb12385d5d58b46d7b8d4196c2893492c73</originalsourceid><addsrcrecordid>eNp9kcFuFSEUhonR2NvqC7gwJG7cjAIHZgZ3ptHWpIkbXRMuML00M3AFps31IXxmT71VExeGxYGc7_yH_D8hLzh7wxkb3lbGlGAdE7Jjo-ai6x-RDZcA3QCgH5MN05J3EpQ6Iae13jDGh0GJp-QENPSDALYhPy7zHQ2phWJnmtZWYos50SX7UGlM07yG5AJNtub9zpZDug4IOltcTHmxtK7lNt7mUuldbDs62xaoP1Rkr6OldkJhWqyPue1wxf7wjlp8J5-X-D146nJqJc8zXmtb_eEZeTLZuYbnD_WMfP344cv5ZXf1-eLT-furzgnVtw68kGJQDoKyfBJaOq8d91oJHYKetlzAqDyecSt7P2xHL7nunRg1SC3cAGfk9VF3X_K3NdRmllhdmGebQl6rAc6Bi54zgeirf9CbvJaEv7unhEZHe0BKHClXcq0lTGZf4oKGGc7MfVrmmJbBtMyvtEyPQy8fpNftEvyfkd_xIABHoGILrS9_d_9H9iduraKp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3112975263</pqid></control><display><type>article</type><title>How enteral nutrition modes influence nasopharyngeal carcinoma survivors with late dysphagia after radiotherapy: a randomized controlled study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Zeng, Hongji ; Zhao, Weijia ; Zhang, Xuyang ; Wang, Xin’ao ; Luo, Pengchao ; Li, Heping ; Wang, Liugen ; Zeng, Xi</creator><creatorcontrib>Zeng, Hongji ; Zhao, Weijia ; Zhang, Xuyang ; Wang, Xin’ao ; Luo, Pengchao ; Li, Heping ; Wang, Liugen ; Zeng, Xi</creatorcontrib><description>Background
Palliation to late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC) continues to be a challenge. Intermittent oro-esophageal tube feeding (IOE) is an emerging enteral nutrition mode that can address nutrition and quality of life issues related to nasogastric tube feeding (NGT).
Objectives
This study aims to investigate the effect of IOE versus NGT in late dysphagia after radiotherapy for NPC.
Methods
This randomized controlled study included 82 NPC survivors with late dysphagia after radiotherapy. The subjects were randomized divided into the IOE and NGT groups (
n
1 =
n
2 = 41). Both groups received standard-of-care rehabilitation. Enteral nutrition supports were administered through IOE or NGT accordingly. This study lasted 2 weeks for each participant. The primary outcome was nutritional status including albumin, hemoglobin, total serum protein, and body mass index. The secondary outcomes were (i) the functional oral intake scale (FOIS), (ii) the penetration-aspiration scale (PAS), (iii) oral transit time (OTT), (iv) hyoid pause time (HPT), (v) pharyngeal transport time (PTT), and (vi) swallowing-quality of life (SWAL-QoL).
Results
Three cases quitted the study halfway and there were no significant baseline differences between the IOE (
n
= 40) and NGT (
n
= 39) groups. Both time and group effects were significant in all nutritional indicators. The time effect was significant in the FOIS levels, OTT and PTT, while the group effect was not. Either time or group effect were insignificant in the PAS levels and HPT. Both group and time effects were significant in the SWAL-QoL total scores (
z
Group
= 5.080,
P
< 0.001;
z
Time
= 18.005,
P
< 0.001). The significance of time and group effects varied across different dimensions of the SWAL-QoL.
Conclusions
Rehabilitation interventions can improve swallowing function among NPC survivors with late dysphagia after radiotherapy. In this population who received standard-of-care rehabilitation, IOE is more conducive to the improvement of nutritional status, and swallowing-related quality of life.
Trial registration
ClinicalTrials.gov Identifier: NCT06301763.</description><identifier>ISSN: 0941-4355</identifier><identifier>ISSN: 1433-7339</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-024-08912-6</identifier><identifier>PMID: 39367230</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Cancer Survivors ; Deglutition Disorders - etiology ; Dysphagia ; Enteral nutrition ; Enteral Nutrition - methods ; Female ; Humans ; Intubation, Gastrointestinal - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nasopharyngeal Carcinoma - radiotherapy ; Nasopharyngeal Neoplasms - radiotherapy ; Nursing ; Nursing Research ; Nutrition ; Nutritional Status ; Oncology ; Pain Medicine ; Quality of Life ; Radiation therapy ; Rehabilitation ; Rehabilitation Medicine ; Survivor ; Throat cancer</subject><ispartof>Supportive care in cancer, 2024-10, Vol.32 (10), p.702, Article 702</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-3d24275c3e5a1f294cd9c1d9529ee9fb12385d5d58b46d7b8d4196c2893492c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-024-08912-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-024-08912-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39367230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Hongji</creatorcontrib><creatorcontrib>Zhao, Weijia</creatorcontrib><creatorcontrib>Zhang, Xuyang</creatorcontrib><creatorcontrib>Wang, Xin’ao</creatorcontrib><creatorcontrib>Luo, Pengchao</creatorcontrib><creatorcontrib>Li, Heping</creatorcontrib><creatorcontrib>Wang, Liugen</creatorcontrib><creatorcontrib>Zeng, Xi</creatorcontrib><title>How enteral nutrition modes influence nasopharyngeal carcinoma survivors with late dysphagia after radiotherapy: a randomized controlled study</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Background
Palliation to late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC) continues to be a challenge. Intermittent oro-esophageal tube feeding (IOE) is an emerging enteral nutrition mode that can address nutrition and quality of life issues related to nasogastric tube feeding (NGT).
Objectives
This study aims to investigate the effect of IOE versus NGT in late dysphagia after radiotherapy for NPC.
Methods
This randomized controlled study included 82 NPC survivors with late dysphagia after radiotherapy. The subjects were randomized divided into the IOE and NGT groups (
n
1 =
n
2 = 41). Both groups received standard-of-care rehabilitation. Enteral nutrition supports were administered through IOE or NGT accordingly. This study lasted 2 weeks for each participant. The primary outcome was nutritional status including albumin, hemoglobin, total serum protein, and body mass index. The secondary outcomes were (i) the functional oral intake scale (FOIS), (ii) the penetration-aspiration scale (PAS), (iii) oral transit time (OTT), (iv) hyoid pause time (HPT), (v) pharyngeal transport time (PTT), and (vi) swallowing-quality of life (SWAL-QoL).
Results
Three cases quitted the study halfway and there were no significant baseline differences between the IOE (
n
= 40) and NGT (
n
= 39) groups. Both time and group effects were significant in all nutritional indicators. The time effect was significant in the FOIS levels, OTT and PTT, while the group effect was not. Either time or group effect were insignificant in the PAS levels and HPT. Both group and time effects were significant in the SWAL-QoL total scores (
z
Group
= 5.080,
P
< 0.001;
z
Time
= 18.005,
P
< 0.001). The significance of time and group effects varied across different dimensions of the SWAL-QoL.
Conclusions
Rehabilitation interventions can improve swallowing function among NPC survivors with late dysphagia after radiotherapy. In this population who received standard-of-care rehabilitation, IOE is more conducive to the improvement of nutritional status, and swallowing-related quality of life.
Trial registration
ClinicalTrials.gov Identifier: NCT06301763.</description><subject>Adult</subject><subject>Aged</subject><subject>Cancer Survivors</subject><subject>Deglutition Disorders - etiology</subject><subject>Dysphagia</subject><subject>Enteral nutrition</subject><subject>Enteral Nutrition - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Intubation, Gastrointestinal - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Carcinoma - radiotherapy</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Nutrition</subject><subject>Nutritional Status</subject><subject>Oncology</subject><subject>Pain Medicine</subject><subject>Quality of Life</subject><subject>Radiation therapy</subject><subject>Rehabilitation</subject><subject>Rehabilitation Medicine</subject><subject>Survivor</subject><subject>Throat cancer</subject><issn>0941-4355</issn><issn>1433-7339</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuFSEUhonR2NvqC7gwJG7cjAIHZgZ3ptHWpIkbXRMuML00M3AFps31IXxmT71VExeGxYGc7_yH_D8hLzh7wxkb3lbGlGAdE7Jjo-ai6x-RDZcA3QCgH5MN05J3EpQ6Iae13jDGh0GJp-QENPSDALYhPy7zHQ2phWJnmtZWYos50SX7UGlM07yG5AJNtub9zpZDug4IOltcTHmxtK7lNt7mUuldbDs62xaoP1Rkr6OldkJhWqyPue1wxf7wjlp8J5-X-D146nJqJc8zXmtb_eEZeTLZuYbnD_WMfP344cv5ZXf1-eLT-furzgnVtw68kGJQDoKyfBJaOq8d91oJHYKetlzAqDyecSt7P2xHL7nunRg1SC3cAGfk9VF3X_K3NdRmllhdmGebQl6rAc6Bi54zgeirf9CbvJaEv7unhEZHe0BKHClXcq0lTGZf4oKGGc7MfVrmmJbBtMyvtEyPQy8fpNftEvyfkd_xIABHoGILrS9_d_9H9iduraKp</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Zeng, Hongji</creator><creator>Zhao, Weijia</creator><creator>Zhang, Xuyang</creator><creator>Wang, Xin’ao</creator><creator>Luo, Pengchao</creator><creator>Li, Heping</creator><creator>Wang, Liugen</creator><creator>Zeng, Xi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20241001</creationdate><title>How enteral nutrition modes influence nasopharyngeal carcinoma survivors with late dysphagia after radiotherapy: a randomized controlled study</title><author>Zeng, Hongji ; Zhao, Weijia ; Zhang, Xuyang ; Wang, Xin’ao ; Luo, Pengchao ; Li, Heping ; Wang, Liugen ; Zeng, Xi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-3d24275c3e5a1f294cd9c1d9529ee9fb12385d5d58b46d7b8d4196c2893492c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cancer Survivors</topic><topic>Deglutition Disorders - etiology</topic><topic>Dysphagia</topic><topic>Enteral nutrition</topic><topic>Enteral Nutrition - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Intubation, Gastrointestinal - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Carcinoma - radiotherapy</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Nutrition</topic><topic>Nutritional Status</topic><topic>Oncology</topic><topic>Pain Medicine</topic><topic>Quality of Life</topic><topic>Radiation therapy</topic><topic>Rehabilitation</topic><topic>Rehabilitation Medicine</topic><topic>Survivor</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Hongji</creatorcontrib><creatorcontrib>Zhao, Weijia</creatorcontrib><creatorcontrib>Zhang, Xuyang</creatorcontrib><creatorcontrib>Wang, Xin’ao</creatorcontrib><creatorcontrib>Luo, Pengchao</creatorcontrib><creatorcontrib>Li, Heping</creatorcontrib><creatorcontrib>Wang, Liugen</creatorcontrib><creatorcontrib>Zeng, Xi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Hongji</au><au>Zhao, Weijia</au><au>Zhang, Xuyang</au><au>Wang, Xin’ao</au><au>Luo, Pengchao</au><au>Li, Heping</au><au>Wang, Liugen</au><au>Zeng, Xi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How enteral nutrition modes influence nasopharyngeal carcinoma survivors with late dysphagia after radiotherapy: a randomized controlled study</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>32</volume><issue>10</issue><spage>702</spage><pages>702-</pages><artnum>702</artnum><issn>0941-4355</issn><issn>1433-7339</issn><eissn>1433-7339</eissn><abstract>Background
Palliation to late dysphagia after radiotherapy for nasopharyngeal carcinoma (NPC) continues to be a challenge. Intermittent oro-esophageal tube feeding (IOE) is an emerging enteral nutrition mode that can address nutrition and quality of life issues related to nasogastric tube feeding (NGT).
Objectives
This study aims to investigate the effect of IOE versus NGT in late dysphagia after radiotherapy for NPC.
Methods
This randomized controlled study included 82 NPC survivors with late dysphagia after radiotherapy. The subjects were randomized divided into the IOE and NGT groups (
n
1 =
n
2 = 41). Both groups received standard-of-care rehabilitation. Enteral nutrition supports were administered through IOE or NGT accordingly. This study lasted 2 weeks for each participant. The primary outcome was nutritional status including albumin, hemoglobin, total serum protein, and body mass index. The secondary outcomes were (i) the functional oral intake scale (FOIS), (ii) the penetration-aspiration scale (PAS), (iii) oral transit time (OTT), (iv) hyoid pause time (HPT), (v) pharyngeal transport time (PTT), and (vi) swallowing-quality of life (SWAL-QoL).
Results
Three cases quitted the study halfway and there were no significant baseline differences between the IOE (
n
= 40) and NGT (
n
= 39) groups. Both time and group effects were significant in all nutritional indicators. The time effect was significant in the FOIS levels, OTT and PTT, while the group effect was not. Either time or group effect were insignificant in the PAS levels and HPT. Both group and time effects were significant in the SWAL-QoL total scores (
z
Group
= 5.080,
P
< 0.001;
z
Time
= 18.005,
P
< 0.001). The significance of time and group effects varied across different dimensions of the SWAL-QoL.
Conclusions
Rehabilitation interventions can improve swallowing function among NPC survivors with late dysphagia after radiotherapy. In this population who received standard-of-care rehabilitation, IOE is more conducive to the improvement of nutritional status, and swallowing-related quality of life.
Trial registration
ClinicalTrials.gov Identifier: NCT06301763.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39367230</pmid><doi>10.1007/s00520-024-08912-6</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2024-10, Vol.32 (10), p.702, Article 702 |
| issn | 0941-4355 1433-7339 1433-7339 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3113126102 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Cancer Survivors Deglutition Disorders - etiology Dysphagia Enteral nutrition Enteral Nutrition - methods Female Humans Intubation, Gastrointestinal - methods Male Medicine Medicine & Public Health Middle Aged Nasopharyngeal Carcinoma - radiotherapy Nasopharyngeal Neoplasms - radiotherapy Nursing Nursing Research Nutrition Nutritional Status Oncology Pain Medicine Quality of Life Radiation therapy Rehabilitation Rehabilitation Medicine Survivor Throat cancer |
| title | How enteral nutrition modes influence nasopharyngeal carcinoma survivors with late dysphagia after radiotherapy: a randomized controlled study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T19%3A34%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=How%20enteral%20nutrition%20modes%20influence%20nasopharyngeal%20carcinoma%20survivors%20with%20late%20dysphagia%20after%20radiotherapy:%20a%20randomized%20controlled%20study&rft.jtitle=Supportive%20care%20in%20cancer&rft.au=Zeng,%20Hongji&rft.date=2024-10-01&rft.volume=32&rft.issue=10&rft.spage=702&rft.pages=702-&rft.artnum=702&rft.issn=0941-4355&rft.eissn=1433-7339&rft_id=info:doi/10.1007/s00520-024-08912-6&rft_dat=%3Cproquest_cross%3E3113126102%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3112975263&rft_id=info:pmid/39367230&rfr_iscdi=true |