Persistent hypertension induces atrial remodeling and atrial fibrillation through DNA damage and ATM/CHK2/p53 signaling pathway

Atrial fibrillation (AF) is the most prevalent arrhythmia in clinical practice, with hypertension emerging as an independent risk factor. Previous literature has established associations between DNA damage response (DDR) and autophagy in relation to the pathogenesis of AF. The aim of this study was...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2025-01, Vol.1871 (1), p.167534, Article 167534
Hauptverfasser:	Huang, Yuting, Zhao, Jikai, Zhou, Zijun, Guo, Xiaodong, Xu, Yinli, Huang, Tao, Meng, Shan, Cao, Zijun, Xu, Dengyue, Zhao, Qiusheng, Yin, Zongtao, Jiang, Hui, Yu, Liming, Wang, Huishan
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Animals Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism ATM Atrial fibrillation Atrial Fibrillation - metabolism Atrial Fibrillation - pathology Atrial Fibrillation - physiopathology Atrial Remodeling Autophagy Cell Line Checkpoint Kinase 2 - genetics Checkpoint Kinase 2 - metabolism DNA Damage DNA damage response Heart Atria - metabolism Heart Atria - pathology Heart Atria - physiopathology Humans Hypertension - genetics Hypertension - metabolism Hypertension - pathology Inflammation Male Mice Rats Rats, Inbred SHR Signal Transduction Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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