PCSK9 inhibitor attenuates cardiac fibrosis in reperfusion injury rat by suppressing inflammatory response and TGF-β1/Smad3 pathway

[Display omitted] Progressive cardiac fibrosis, a hallmark of heart failure, remains poorly understood regarding Proprotein convertase subtilisin/kexin type 9 (PCSK9) ’s role. This study aims to elucidate PCSK9′s involvement in cardiac fibrosis. After ischemia/reperfusion (I/R) injury surgery in rat...

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Veröffentlicht in:	Biochemical pharmacology 2024-12, Vol.230 (Pt 1), p.116563, Article 116563
Hauptverfasser:	Huang, Qing, Zhou, Zhina, Xu, Lei, Zhan, Peng, Huang, Guangwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac fibrosis Fibrosis Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammatory response Ischemia reperfusion injury Male Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocardium - pathology PCSK9 PCSK9 Inhibitors Proprotein Convertase 9 Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology Smad3 Protein - metabolism TGF-β1/Smad3 Transforming Growth Factor beta1 - metabolism
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