An Adenosine Analogue Library Reveals Insights into Active Sites of Protein Arginine Methyltransferases and Enables the Discovery of a Selective PRMT4 Inhibitor

Protein arginine methyltransferases (PRMTs) represent promising drug targets. However, the lack of isoform-selective chemical probes poses a significant hurdle in deciphering their biological roles. To address this issue, we devised a library of 100 diverse adenosine analogues, enabling a detailed e...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 2024-10, Vol.67 (20), p.18053-18069
Hauptverfasser:	Deng, Youchao, Kim, Eui-Jun, Song, Xiaosheng, Kulkarni, Akshay S., Zhu, Ryan X., Wang, Yidan, Bush, Michelle, Dong, Aiping, Noinaj, Nicholas, Min, Jinrong, Xu, Wei, Huang, Rong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!