Intestinal Lactobacillus murinus -derived small RNAs target porcine polyamine metabolism
Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ-free models possess elevated polyamine levels in the colon. Mechanistically, intestinal -derived small RNAs in extracellular vesicles down-regulate hos...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2024-10, Vol.121 (41), p.e2413241121 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Fan, Lijuan Liu, Bingnan Wang, Youxia Tang, Bin Xu, Tianqi Fu, Jian Wang, Chuanlong Liu, Yuan Ge, Liangpeng Wei, Hong Ren, Wenkai |
| description | Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ-free models possess elevated polyamine levels in the colon. Mechanistically, intestinal
-derived small RNAs in extracellular vesicles down-regulate host polyamine metabolism by targeting the expression of enzymes in polyamine metabolism. In addition,
delays recovery of dextran sodium sulfate-induced colitis by reducing polyamine levels in mice. Notably, a decline in the abundance of small RNAs was observed in the colon of mice with colorectal cancer (CRC) and human CRC specimens, accompanied by elevated polyamine levels. Collectively, our study identifies a specific underlying mechanism used by intestinal microbiota to modulate host polyamine metabolism, which provides potential intervention for the treatment of polyamine-associated diseases. |
| doi_str_mv | 10.1073/pnas.2413241121 |
| format | Article |
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-derived small RNAs in extracellular vesicles down-regulate host polyamine metabolism by targeting the expression of enzymes in polyamine metabolism. In addition,
delays recovery of dextran sodium sulfate-induced colitis by reducing polyamine levels in mice. Notably, a decline in the abundance of small RNAs was observed in the colon of mice with colorectal cancer (CRC) and human CRC specimens, accompanied by elevated polyamine levels. Collectively, our study identifies a specific underlying mechanism used by intestinal microbiota to modulate host polyamine metabolism, which provides potential intervention for the treatment of polyamine-associated diseases.</description><identifier>ISSN: 0027-8424</identifier><identifier>ISSN: 1091-6490</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.2413241121</identifier><identifier>PMID: 39361652</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; Colitis ; Colitis - chemically induced ; Colitis - metabolism ; Colitis - microbiology ; Colon ; Colon - metabolism ; Colon - microbiology ; Colon cancer ; Colorectal carcinoma ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - microbiology ; Dextran ; Dextran Sulfate ; Dextrans ; Digestive system ; Extracellular Vesicles - metabolism ; Gastrointestinal Microbiome ; Gastrointestinal tract ; Germfree ; Humans ; Intestinal microflora ; Lactobacillus ; Lactobacillus - genetics ; Lactobacillus - metabolism ; Mice ; Microbiota ; Microorganisms ; Polyamines ; Polyamines - metabolism ; Sodium sulfate ; Swine</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2024-10, Vol.121 (41), p.e2413241121</ispartof><rights>Copyright National Academy of Sciences Oct 8, 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c250t-5db92ddf869a69fa5bb042f9a2852dd01e4b7d6f3011669b029adb76f17c53133</cites><orcidid>0000-0002-9622-6471</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39361652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fan, Lijuan</creatorcontrib><creatorcontrib>Liu, Bingnan</creatorcontrib><creatorcontrib>Wang, Youxia</creatorcontrib><creatorcontrib>Tang, Bin</creatorcontrib><creatorcontrib>Xu, Tianqi</creatorcontrib><creatorcontrib>Fu, Jian</creatorcontrib><creatorcontrib>Wang, Chuanlong</creatorcontrib><creatorcontrib>Liu, Yuan</creatorcontrib><creatorcontrib>Ge, Liangpeng</creatorcontrib><creatorcontrib>Wei, Hong</creatorcontrib><creatorcontrib>Ren, Wenkai</creatorcontrib><title>Intestinal Lactobacillus murinus -derived small RNAs target porcine polyamine metabolism</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ-free models possess elevated polyamine levels in the colon. Mechanistically, intestinal
-derived small RNAs in extracellular vesicles down-regulate host polyamine metabolism by targeting the expression of enzymes in polyamine metabolism. In addition,
delays recovery of dextran sodium sulfate-induced colitis by reducing polyamine levels in mice. Notably, a decline in the abundance of small RNAs was observed in the colon of mice with colorectal cancer (CRC) and human CRC specimens, accompanied by elevated polyamine levels. Collectively, our study identifies a specific underlying mechanism used by intestinal microbiota to modulate host polyamine metabolism, which provides potential intervention for the treatment of polyamine-associated diseases.</description><subject>Animals</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - metabolism</subject><subject>Colitis - microbiology</subject><subject>Colon</subject><subject>Colon - metabolism</subject><subject>Colon - microbiology</subject><subject>Colon cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - microbiology</subject><subject>Dextran</subject><subject>Dextran Sulfate</subject><subject>Dextrans</subject><subject>Digestive system</subject><subject>Extracellular Vesicles - metabolism</subject><subject>Gastrointestinal Microbiome</subject><subject>Gastrointestinal tract</subject><subject>Germfree</subject><subject>Humans</subject><subject>Intestinal microflora</subject><subject>Lactobacillus</subject><subject>Lactobacillus - genetics</subject><subject>Lactobacillus - metabolism</subject><subject>Mice</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Polyamines</subject><subject>Polyamines - metabolism</subject><subject>Sodium sulfate</subject><subject>Swine</subject><issn>0027-8424</issn><issn>1091-6490</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtLw0AQhxdRbK2evUnAi5e0s49sssdSfBSKgih4C7vJRrZsHu4mQv97N7YqeBh-w_DNwHwIXWKYY0jpomuknxOGaShM8BGaYhA45kzAMZoCkDTOGGETdOb9FgBEksEpmlBBOeYJmaK3ddNr35tG2mgji75VsjDWDj6qB2eakHGpnfnUZeRraW30_Lj0US_du-6jrnWFaXRIu5P12NW6l6q1xtfn6KSS1uuLQ87Q693ty-oh3jzdr1fLTVyQBPo4KZUgZVllXEguKpkoBYxUQpIsCXPAmqm05BUFjDkXCoiQpUp5hdMioZjSGbrZ3-1c-zGEV_La-EJbKxvdDj6nwUuWpIyO6PU_dNsOLnz-TfEUYwYkUIs9VbjWe6ervHOmlm6XY8hH6fkoPf-THjauDncHVevyl_-xTL8AYkV9cA</recordid><startdate>20241008</startdate><enddate>20241008</enddate><creator>Fan, Lijuan</creator><creator>Liu, Bingnan</creator><creator>Wang, Youxia</creator><creator>Tang, Bin</creator><creator>Xu, Tianqi</creator><creator>Fu, Jian</creator><creator>Wang, Chuanlong</creator><creator>Liu, Yuan</creator><creator>Ge, Liangpeng</creator><creator>Wei, Hong</creator><creator>Ren, Wenkai</creator><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9622-6471</orcidid></search><sort><creationdate>20241008</creationdate><title>Intestinal Lactobacillus murinus -derived small RNAs target porcine polyamine metabolism</title><author>Fan, Lijuan ; 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however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ-free models possess elevated polyamine levels in the colon. Mechanistically, intestinal
-derived small RNAs in extracellular vesicles down-regulate host polyamine metabolism by targeting the expression of enzymes in polyamine metabolism. In addition,
delays recovery of dextran sodium sulfate-induced colitis by reducing polyamine levels in mice. Notably, a decline in the abundance of small RNAs was observed in the colon of mice with colorectal cancer (CRC) and human CRC specimens, accompanied by elevated polyamine levels. Collectively, our study identifies a specific underlying mechanism used by intestinal microbiota to modulate host polyamine metabolism, which provides potential intervention for the treatment of polyamine-associated diseases.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>39361652</pmid><doi>10.1073/pnas.2413241121</doi><orcidid>https://orcid.org/0000-0002-9622-6471</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Colitis Colitis - chemically induced Colitis - metabolism Colitis - microbiology Colon Colon - metabolism Colon - microbiology Colon cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - microbiology Dextran Dextran Sulfate Dextrans Digestive system Extracellular Vesicles - metabolism Gastrointestinal Microbiome Gastrointestinal tract Germfree Humans Intestinal microflora Lactobacillus Lactobacillus - genetics Lactobacillus - metabolism Mice Microbiota Microorganisms Polyamines Polyamines - metabolism Sodium sulfate Swine |
| title | Intestinal Lactobacillus murinus -derived small RNAs target porcine polyamine metabolism |
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