Ameliorative effect of Schisandrol B against Diosbulbin B-induced hepatotoxicity via inhibiting CYP3A4-mediated bioactivation

Diosbulbin B (DBB), the major component isolated from herbal medicine Dioscorea bulbifera L. (DBL), can trigger severe hepatotoxicity. The previous studies demonstrated that DBB-induced hepatotoxicity is closely relevant to the bioactivation mediated by CYP3A4 and subsequent generation of adducts wi...

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Veröffentlicht in:	Toxicology and applied pharmacology 2024-11, Vol.492, p.117116, Article 117116
Hauptverfasser:	Lin, Dongju, Wang, Shuo, Yang, Bufan, Li, Guangyao
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation, Metabolic Animals Bioactivation Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - prevention & control Cyclooctanes - pharmacology Cyclooctanes - toxicity Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inhibitors - pharmacology Diosbulbin B Dioxoles Dose-Response Relationship, Drug Glutathione - metabolism Hepatotoxicity Heterocyclic Compounds, 4 or More Rings Humans Lignans - pharmacokinetics Lignans - pharmacology Liver - drug effects Liver - metabolism Liver - pathology Male Mice Microsomes, Liver - drug effects Microsomes, Liver - metabolism Polycyclic Compounds - pharmacology Polycyclic Compounds - toxicity Schisandrol B
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