Berberine extends healthspan and delays neurodegenerative diseases in Caenorhabditis elegans through ROS-dependent PMK-1/SKN-1 activation

•Berberine significantly extends the healthy lifespan in wild type C. elegans.•Berberine generates ROS, which is followed by the activation of PMK-1/SKN-1dependent manner to extend healthspan.•Berberine also delays neurodegeneration diseases such as Alzheimer's and polyglutamine disease through...

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Veröffentlicht in:	Archives of gerontology and geriatrics 2025-01, Vol.128, p.105644, Article 105644
Hauptverfasser:	Xiao, Yi, Zhang, Li, Zhou, Hanlin, Cui, Yingwen, Chen, Keer, Zhang, Han, Wu, Qinyi, Liu, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects Animals Berberine Berberine - pharmacology Caenorhabditis elegans - drug effects Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Healthspan Longevity - drug effects Mitogen-Activated Protein Kinases Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Oxidative Stress - drug effects PMK-1/SKN-1dependent manner Reactive Oxygen Species - metabolism ROS Signal Transduction - drug effects Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism
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