GSDMB interacts with IGF2BP1 to suppress colorectal cancer progression by modulating DUSP6-ERK pathway

•Aberrantly upregulated GSDMB suppresses the colorectal cancer progression.•GSDMB-mediated DUSP-ERK pathway determines cancer cell fate.•GSDMB interacts with IGF2BP1 to regulate DUSP6-ERK pathway.•Transgenic expression of epithelial GSDMB develops diminished tumorigenesis. There is growing evidence...

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Veröffentlicht in:	International immunopharmacology 2024-12, Vol.143 (Pt 1), p.113280, Article 113280
Hauptverfasser:	Jiang, Haiyang, Deng, Liting, Lin, Zexing, Yang, Kui, Yang, Jun, Zhao, Wei, Gong, Wenbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell death Cell proliferation Colorectal cancer GSDMB IGF2BP1
Online-Zugang:	Volltext
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