Attenuation of inflammation, oxidative stress and TGF-β1/Smad3 signaling and upregulation of Nrf2/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity

Heavy metals are toxic environmental pollutants with serious health effects on humans and animals. Cadmium (Cd) is known for its serious nephrotoxic effect and its toxicity involves oxidative stress (OS) and inflammation. Diallyl disulfide (DADS), a main constituent of garlic, exhibites cytoprotecti...

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Veröffentlicht in:	Tissue & cell 2024-12, Vol.91, p.102576, Article 102576
Hauptverfasser:	Alruhaimi, Reem S., Hassanein, Emad H.M., Ahmeda, Ahmad F., Alnasser, Sulaiman M., Atwa, Ahmed M., Sabry, Mostafa, Alzoghaibi, Mohammed A., Mahmoud, Ayman M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allyl Compounds - pharmacology Animals Antioxidants - metabolism Antioxidants - pharmacology Cadmium Cadmium - toxicity Disulfides - pharmacology Garlic Heavy metals Inflammation Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Male Nephrotoxicity NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects PPAR gamma - metabolism Protective Agents - pharmacology Rats Rats, Wistar Signal Transduction - drug effects Smad3 Protein - metabolism Transforming Growth Factor beta1 - metabolism Up-Regulation - drug effects
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