Genetic deletion of the apoptosis associated speck like protein containing a card in LysM+ macrophages attenuates spinal cord injury by regulating M1/M2 polarization through ASC-dependent inflammasome signaling axis

Apoptosis associated speck like protein containing a card (ASC), the key adaptor protein of the assembly and activation of canonical inflammasomes, has been found to play a significant role in neuroinflammation after spinal cord injury (SCI). The previous studies indicated that widely block or knock...

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Veröffentlicht in:	Experimental neurology 2024-12, Vol.382, p.114982, Article 114982
Hauptverfasser:	Ding, Shu-Qin, Yan, Hua-Zheng, Gao, Jian-Xiong, Chen, Yu-Qing, Zhang, Nan, Wang, Rui, Li, Jiang-Yan, Hu, Jian-Guo, Lü, He-Zuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis-associated speck-like protein containing a card Conditional gene knockout LysM+ macrophages Spinal cord injury
Online-Zugang:	Volltext
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