COX-2 targeted therapy for diabetic foot ulcers using T7-enhanced CS-PVA membranes

•Chitosan-polyvinylalcohol (CS-PVA) membrane inhibits growth of pathogenic bacteria.•T7, a selective COX-2 inhibitor accelerates wound healing potential of CS-PVA.•T7 reduces inflammation by selectively inhibiting COX-2 enzyme.•T7 increases TGF-β expression in wound healing. Diabetic foot ulcers can...

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Veröffentlicht in:	International immunopharmacology 2024-12, Vol.143 (Pt 1), p.113206, Article 113206
Hauptverfasser:	Murugan, Raghul, Ashok, Kumar, Ramya Ranjan Nayak, S.P., Deivasigamani, Priya, Almutairi, Mikhlid H., Almutairi, Bader O., Guru, Ajay, Muthu Kumaradoss, Kathiravan, Arockiaraj, Jesu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antibacterial Chitosan - chemistry Chitosan-polyvinylalcohol membrane Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase 2 Inhibitors - therapeutic use Diabetic Foot - drug therapy Diabetic Foot - pathology Diabetic foot ulcers Drug release Humans Membranes, Artificial Polyvinyl Alcohol - chemistry Wound healing Wound Healing - drug effects Zebrafish
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