Mortality associated with clozapine: what is the evidence?
While clozapine has risks, relative risk of fatality is overestimated. The UK pharmacovigilance programme is efficient, but comparisons with other drugs can mislead because of reporting variations. Clozapine actually lowers mortality, partly by reducing schizophrenia-related suicides, but preventabl...
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| Veröffentlicht in: | British journal of psychiatry 2024-09, Vol.225 (3), p.357-359 |
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| container_title | British journal of psychiatry |
| container_volume | 225 |
| creator | Fernandez-Egea, Emilio Flanagan, Robert J. Taylor, David Gaughran, Fiona Lawrie, Stephen M. Jenkins, Christopher Smith, Shubulade Howes, Oliver D. MacCabe, James H. |
| description | While clozapine has risks, relative risk of fatality is overestimated. The UK pharmacovigilance programme is efficient, but comparisons with other drugs can mislead because of reporting variations. Clozapine actually lowers mortality, partly by reducing schizophrenia-related suicides, but preventable deaths still occur. Clozapine should be used earlier and more widely, but there should be better monitoring and better management of toxicity. |
| doi_str_mv | 10.1192/bjp.2024.88 |
| format | Article |
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| ispartof | British journal of psychiatry, 2024-09, Vol.225 (3), p.357-359 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Cambridge University Press Journals Complete |
| subjects | Academic Psychiatry Antipsychotic Agents - adverse effects Antipsychotics Avoidable BJPsych Editorial Blood Clozapine Clozapine - adverse effects Fatalities Hematology Humans Licenses Mental disorders Monitoring systems Mortality Pharmacovigilance Pneumonia Professionals Psychosis Psychotropic drugs Risk assessment Risk factors Schizophrenia Schizophrenia - drug therapy Schizophrenia - mortality Suicide Suicide - statistics & numerical data Toxicity United Kingdom - epidemiology |
| title | Mortality associated with clozapine: what is the evidence? |
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