Optimal Preservation of PFFs in Glycerol Enhances Suitability for Modeling Parkinson's Disease

Injecting α‐synuclein pre‐formed fibrils (αSyn PFFs) into various tissues and organs involves converting monomeric αSyn into a fibrillar form, inducing extensive αSyn pathology that effectively models Parkinson's disease (PD). However, the distinct physicochemical properties of αSyn amyloid fib...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-12, Vol.20 (51), p.e2401552-n/a
Hauptverfasser:	Mao, Hengxu, Kuang, Yaoyun, Huang, Weiqing, Gan, Tingting, Dai, Wei, Guo, Wenyuan, Chen, Minshan, Su, Zhongqiang, Shu, Hui, Wu, Tengteng, Wang, Xiaobei, Wu, Zhuohua, Li, Hongyan, Liu, Qin, Li, Hong, Huang, Xiaoyun, Yang, Xinling, Xu, Ping‐Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - metabolism Amyloid - chemistry Amyloid - metabolism Animals Cold storage Denaturation disassemble Disease Models, Animal Dismantling Glycerol Glycerol - chemistry Glycerol - pharmacology Humans In vivo methods and tests Low temperature Neurons - drug effects Neurons - metabolism Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Pathology PFFs α‐synuclein
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