Long-term neurodevelopmental outcomes at three years in preterm infants born before 29 Weeks gestation following Preterm Premature Rupture of Membranes (PPROM)
To determine the association between preterm premature rupture of membranes (PPROM) and neurodevelopmental impairment (NDI) at 3 years corrected age (CA) in infants born before 29 weeks of gestational age (GA). Infants born before 29 weeks GA between 2005 and 2017 were included. The primary outcome...
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Veröffentlicht in: | Journal of perinatology 2024-09 |
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creator | Bhullar, Harkirat Stritzke, Amelie Makarchuk, Sue Tang, Selphee Lodha, Abhay |
description | To determine the association between preterm premature rupture of membranes (PPROM) and neurodevelopmental impairment (NDI) at 3 years corrected age (CA) in infants born before 29 weeks of gestational age (GA).
Infants born before 29 weeks GA between 2005 and 2017 were included. The primary outcome was a composite of death or NDI (full-scale intelligence quotient |
doi_str_mv | 10.1038/s41372-024-02134-8 |
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Infants born before 29 weeks GA between 2005 and 2017 were included. The primary outcome was a composite of death or NDI (full-scale intelligence quotient<85, cerebral palsy, vision or hearing impairment) at 3 years of CA. Infants were stratified by maternal PPROM status. Associations were explored using multivariate models.
Of 1231 participants, 481 were in the PPROM group, and 750 were in the No PPROM group. After adjusting for factors, the odds ratio of death or NDI for PPROM vs. No PPROM was 1.22 (95% Confidence Interval 0.93-1.59).
Our study suggests that PPROM was not associated with an increased risk of a composite outcome of death or NDI at 3 years CA.</description><identifier>ISSN: 0743-8346</identifier><identifier>ISSN: 1476-5543</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-024-02134-8</identifier><identifier>PMID: 39349683</identifier><language>eng</language><publisher>United States</publisher><ispartof>Journal of perinatology, 2024-09</ispartof><rights>2024. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c184t-9c0c037e52615f4d14efae26d979afa56166b46f72a968017ce16559a06a5fbf3</cites><orcidid>0000-0003-3685-3569 ; 0000-0003-4809-0765 ; 0000-0001-7309-9011</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39349683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhullar, Harkirat</creatorcontrib><creatorcontrib>Stritzke, Amelie</creatorcontrib><creatorcontrib>Makarchuk, Sue</creatorcontrib><creatorcontrib>Tang, Selphee</creatorcontrib><creatorcontrib>Lodha, Abhay</creatorcontrib><title>Long-term neurodevelopmental outcomes at three years in preterm infants born before 29 Weeks gestation following Preterm Premature Rupture of Membranes (PPROM)</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><description>To determine the association between preterm premature rupture of membranes (PPROM) and neurodevelopmental impairment (NDI) at 3 years corrected age (CA) in infants born before 29 weeks of gestational age (GA).
Infants born before 29 weeks GA between 2005 and 2017 were included. The primary outcome was a composite of death or NDI (full-scale intelligence quotient<85, cerebral palsy, vision or hearing impairment) at 3 years of CA. Infants were stratified by maternal PPROM status. Associations were explored using multivariate models.
Of 1231 participants, 481 were in the PPROM group, and 750 were in the No PPROM group. After adjusting for factors, the odds ratio of death or NDI for PPROM vs. No PPROM was 1.22 (95% Confidence Interval 0.93-1.59).
Our study suggests that PPROM was not associated with an increased risk of a composite outcome of death or NDI at 3 years CA.</description><issn>0743-8346</issn><issn>1476-5543</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kctOxCAUhonR6Hh5AReGpS6qUCi0S2O8JWOcGI1LQjuHsdpCBarxaXxVcWZ0cfIvzv-fSz6EDik5pYSVZ4FTJvOM5DwVZTwrN9CEcimyouBsE02I5CwrGRc7aDeEV0J-m3Ib7bCK8UqUbIK-p84usgi-xxZG7-bwAZ0berBRd9iNsXE9BKwjji8eAH-B9gG3Fg8elqnWGm1jwLXzFtdgnAecV_gZ4C3gBYSoY-ssNq7r3GdrF3i2DibtdRyT_WEcluoMvoO-9tqmjcez2cP93ck-2jK6C3Cw1j30dHX5eHGTTe-vby_Op1lDSx6zqiENYRKKXNDC8DnlYDTkYl7JShtdCCpEzYWRuU5_EyoboKIoKk2ELkxt2B46Xs0dvHsf09mqb0MDXZeOcWNQjFIqmBC5TNZ8ZW28C8GDUYNve-2_FCXqF4xagVEJjFqCUWUKHa3nj3UP8__IHwn2Aw8fi8M</recordid><startdate>20240930</startdate><enddate>20240930</enddate><creator>Bhullar, Harkirat</creator><creator>Stritzke, Amelie</creator><creator>Makarchuk, Sue</creator><creator>Tang, Selphee</creator><creator>Lodha, Abhay</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3685-3569</orcidid><orcidid>https://orcid.org/0000-0003-4809-0765</orcidid><orcidid>https://orcid.org/0000-0001-7309-9011</orcidid></search><sort><creationdate>20240930</creationdate><title>Long-term neurodevelopmental outcomes at three years in preterm infants born before 29 Weeks gestation following Preterm Premature Rupture of Membranes (PPROM)</title><author>Bhullar, Harkirat ; Stritzke, Amelie ; Makarchuk, Sue ; Tang, Selphee ; Lodha, Abhay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c184t-9c0c037e52615f4d14efae26d979afa56166b46f72a968017ce16559a06a5fbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhullar, Harkirat</creatorcontrib><creatorcontrib>Stritzke, Amelie</creatorcontrib><creatorcontrib>Makarchuk, Sue</creatorcontrib><creatorcontrib>Tang, Selphee</creatorcontrib><creatorcontrib>Lodha, Abhay</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhullar, Harkirat</au><au>Stritzke, Amelie</au><au>Makarchuk, Sue</au><au>Tang, Selphee</au><au>Lodha, Abhay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term neurodevelopmental outcomes at three years in preterm infants born before 29 Weeks gestation following Preterm Premature Rupture of Membranes (PPROM)</atitle><jtitle>Journal of perinatology</jtitle><addtitle>J Perinatol</addtitle><date>2024-09-30</date><risdate>2024</risdate><issn>0743-8346</issn><issn>1476-5543</issn><eissn>1476-5543</eissn><abstract>To determine the association between preterm premature rupture of membranes (PPROM) and neurodevelopmental impairment (NDI) at 3 years corrected age (CA) in infants born before 29 weeks of gestational age (GA).
Infants born before 29 weeks GA between 2005 and 2017 were included. The primary outcome was a composite of death or NDI (full-scale intelligence quotient<85, cerebral palsy, vision or hearing impairment) at 3 years of CA. Infants were stratified by maternal PPROM status. Associations were explored using multivariate models.
Of 1231 participants, 481 were in the PPROM group, and 750 were in the No PPROM group. After adjusting for factors, the odds ratio of death or NDI for PPROM vs. No PPROM was 1.22 (95% Confidence Interval 0.93-1.59).
Our study suggests that PPROM was not associated with an increased risk of a composite outcome of death or NDI at 3 years CA.</abstract><cop>United States</cop><pmid>39349683</pmid><doi>10.1038/s41372-024-02134-8</doi><orcidid>https://orcid.org/0000-0003-3685-3569</orcidid><orcidid>https://orcid.org/0000-0003-4809-0765</orcidid><orcidid>https://orcid.org/0000-0001-7309-9011</orcidid></addata></record> |
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title | Long-term neurodevelopmental outcomes at three years in preterm infants born before 29 Weeks gestation following Preterm Premature Rupture of Membranes (PPROM) |
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