Application of shadowgraph imaging (SGI) particle characterisation data to interpret the impact of varying test conditions on powder dissolution and to develop an automated agglomeration identification method (AIM) in the USP flow-through apparatus

[Display omitted] •Shadowgraph imaging can detect suspended particles in USP 4 dissolution apparatus.•Image-analysis enables particle characterisation during dissolution testing.•Trends in particle dispersal behaviour can explain powder dissolution in USP 4.•Development of image analysis approach fo...

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Veröffentlicht in:	International journal of pharmaceutics 2024-12, Vol.666, p.124778, Article 124778
Hauptverfasser:	Taseva, Alexandra R., Persoons, Tim, Healy, Anne Marie, D’Arcy, Deirdre M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregate and agglomerate AI method development Dissolution Image analysis Real time monitoring USP 4 flow-through apparatus
Online-Zugang:	Volltext
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