Effects of beetroot (Beta vulgaris) supplements on selective enzymatic and non-enzymatic antioxidants in iron deficiency anemia
Iron deficiency anemia (IDA) is not only associated with iron deficiency but has shown strong association with the over production of free radicles and deficiency of antioxidant enzymes. The result of this imbalance is oxidative stress (OS) which is now considered as an important associated factor w...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2024-07, Vol.37 (4), p.803 |
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| container_title | Pakistan journal of pharmaceutical sciences |
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| creator | Khalid, Shamaila Mahboob Alam, Syed Mohammad Saud Hassan, Syed Nadeem Ahmad, Shaikh Zehra, Dabeeran Imran-Ul-Haq, Hafiz Syed |
| description | Iron deficiency anemia (IDA) is not only associated with iron deficiency but has shown strong association with the over production of free radicles and deficiency of antioxidant enzymes. The result of this imbalance is oxidative stress (OS) which is now considered as an important associated factor with various diseases. Treating IDA in most of cases with oral iron supplements results in more OS as iron is a transition metal. A more suitable alternate for iron supplementation is Beta vulgaris supplement, which being herbal in origin is far less associated with side effects. We studied effects of beta vulgaris supplements on enzymatic and non-enzymatic antioxidants in IDA patients. A significant increase in all study parameters were observed after treatment (p |
| doi_str_mv | 10.36721/PJPS.2024.37.4.REG.803-808.1 |
| format | Article |
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The result of this imbalance is oxidative stress (OS) which is now considered as an important associated factor with various diseases. Treating IDA in most of cases with oral iron supplements results in more OS as iron is a transition metal. A more suitable alternate for iron supplementation is Beta vulgaris supplement, which being herbal in origin is far less associated with side effects. We studied effects of beta vulgaris supplements on enzymatic and non-enzymatic antioxidants in IDA patients. A significant increase in all study parameters were observed after treatment (p <0.05). When pre-supplemental values of super oxide dismutase (SOD) and reduced glutathione (GSH-PX) of IDA were compared with post-supplemental values, they were significantly low (p <0.05). A positive correlation was noted between the two antioxidants and hemoglobin (Hb) values suggesting a direct relationship between antioxidant status and Hb levels. Non enzymatic antioxidants included vitamin A,C and E. We also found a significant improvement (p <0.05) of these vitamins when compared with their initial values and the control group. Our study shows improvement of antioxidant status of anemic patients with 12 week supplementation of Beta vulgaris.</description><identifier>ISSN: 1011-601X</identifier><identifier>DOI: 10.36721/PJPS.2024.37.4.REG.803-808.1</identifier><identifier>PMID: 39348645</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Adult ; Anemia, Iron-Deficiency - blood ; Anemia, Iron-Deficiency - diet therapy ; Anemia, Iron-Deficiency - drug therapy ; Antioxidants - pharmacology ; Beta vulgaris - chemistry ; Dietary Supplements ; Female ; Glutathione Peroxidase - metabolism ; Hemoglobins - metabolism ; Humans ; Male ; Middle Aged ; Oxidative Stress - drug effects ; Superoxide Dismutase - blood ; Superoxide Dismutase - metabolism ; Treatment Outcome ; Young Adult</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2024-07, Vol.37 (4), p.803</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39348645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalid, Shamaila</creatorcontrib><creatorcontrib>Mahboob Alam, Syed Mohammad</creatorcontrib><creatorcontrib>Saud Hassan, Syed</creatorcontrib><creatorcontrib>Nadeem Ahmad, Shaikh</creatorcontrib><creatorcontrib>Zehra, Dabeeran</creatorcontrib><creatorcontrib>Imran-Ul-Haq, Hafiz Syed</creatorcontrib><title>Effects of beetroot (Beta vulgaris) supplements on selective enzymatic and non-enzymatic antioxidants in iron deficiency anemia</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Iron deficiency anemia (IDA) is not only associated with iron deficiency but has shown strong association with the over production of free radicles and deficiency of antioxidant enzymes. The result of this imbalance is oxidative stress (OS) which is now considered as an important associated factor with various diseases. Treating IDA in most of cases with oral iron supplements results in more OS as iron is a transition metal. A more suitable alternate for iron supplementation is Beta vulgaris supplement, which being herbal in origin is far less associated with side effects. We studied effects of beta vulgaris supplements on enzymatic and non-enzymatic antioxidants in IDA patients. A significant increase in all study parameters were observed after treatment (p <0.05). When pre-supplemental values of super oxide dismutase (SOD) and reduced glutathione (GSH-PX) of IDA were compared with post-supplemental values, they were significantly low (p <0.05). A positive correlation was noted between the two antioxidants and hemoglobin (Hb) values suggesting a direct relationship between antioxidant status and Hb levels. Non enzymatic antioxidants included vitamin A,C and E. We also found a significant improvement (p <0.05) of these vitamins when compared with their initial values and the control group. Our study shows improvement of antioxidant status of anemic patients with 12 week supplementation of Beta vulgaris.</description><subject>Adult</subject><subject>Anemia, Iron-Deficiency - blood</subject><subject>Anemia, Iron-Deficiency - diet therapy</subject><subject>Anemia, Iron-Deficiency - drug therapy</subject><subject>Antioxidants - pharmacology</subject><subject>Beta vulgaris - chemistry</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress - drug effects</subject><subject>Superoxide Dismutase - blood</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtKAzEUhrNQbK2-gmQj1MWMuU0ms9RSq1KweAF3Qzo5kcjcnGSKdeOrO8UKrg785_sOhx-hc0piLlNGL1f3q6eYESZinsYifpwvYkV4pIiK6QEaU0JpJAl9HaFj798JkSLLsiM04hkXSopkjL7n1kIRPG4sXgOErmkCnl5D0HjTl2-6c_4C-75tS6ig3nE19lAOitsAhvprW-ngCqxrg-umjv4nwTWfzuid5WrsukE1YF3hoC62wx4qp0_QodWlh9P9nKCXm_nz7DZaPizuZlfLqKWChsgoRhKrpCaKZYwaSKWSmSUWEpbYIdBCphKygiUJCGNVZnhBtEg0l0ZLxido-nu37ZqPHnzIK-cLKMvhjab3OaeUSi45Twb0bI_26wpM3nau0t02_yuN_wBKu3H8</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Khalid, Shamaila</creator><creator>Mahboob Alam, Syed Mohammad</creator><creator>Saud Hassan, Syed</creator><creator>Nadeem Ahmad, Shaikh</creator><creator>Zehra, Dabeeran</creator><creator>Imran-Ul-Haq, Hafiz Syed</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202407</creationdate><title>Effects of beetroot (Beta vulgaris) supplements on selective enzymatic and non-enzymatic antioxidants in iron deficiency anemia</title><author>Khalid, Shamaila ; Mahboob Alam, Syed Mohammad ; Saud Hassan, Syed ; Nadeem Ahmad, Shaikh ; Zehra, Dabeeran ; Imran-Ul-Haq, Hafiz Syed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-d8205f86a082921de76869f0fe525f21da4676e9c255e4df89d3c0a45a36da623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Anemia, Iron-Deficiency - blood</topic><topic>Anemia, Iron-Deficiency - diet therapy</topic><topic>Anemia, Iron-Deficiency - drug therapy</topic><topic>Antioxidants - pharmacology</topic><topic>Beta vulgaris - chemistry</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress - drug effects</topic><topic>Superoxide Dismutase - blood</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalid, Shamaila</creatorcontrib><creatorcontrib>Mahboob Alam, Syed Mohammad</creatorcontrib><creatorcontrib>Saud Hassan, Syed</creatorcontrib><creatorcontrib>Nadeem Ahmad, Shaikh</creatorcontrib><creatorcontrib>Zehra, Dabeeran</creatorcontrib><creatorcontrib>Imran-Ul-Haq, Hafiz Syed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalid, Shamaila</au><au>Mahboob Alam, Syed Mohammad</au><au>Saud Hassan, Syed</au><au>Nadeem Ahmad, Shaikh</au><au>Zehra, Dabeeran</au><au>Imran-Ul-Haq, Hafiz Syed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of beetroot (Beta vulgaris) supplements on selective enzymatic and non-enzymatic antioxidants in iron deficiency anemia</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2024-07</date><risdate>2024</risdate><volume>37</volume><issue>4</issue><spage>803</spage><pages>803-</pages><issn>1011-601X</issn><abstract>Iron deficiency anemia (IDA) is not only associated with iron deficiency but has shown strong association with the over production of free radicles and deficiency of antioxidant enzymes. The result of this imbalance is oxidative stress (OS) which is now considered as an important associated factor with various diseases. Treating IDA in most of cases with oral iron supplements results in more OS as iron is a transition metal. A more suitable alternate for iron supplementation is Beta vulgaris supplement, which being herbal in origin is far less associated with side effects. We studied effects of beta vulgaris supplements on enzymatic and non-enzymatic antioxidants in IDA patients. A significant increase in all study parameters were observed after treatment (p <0.05). When pre-supplemental values of super oxide dismutase (SOD) and reduced glutathione (GSH-PX) of IDA were compared with post-supplemental values, they were significantly low (p <0.05). A positive correlation was noted between the two antioxidants and hemoglobin (Hb) values suggesting a direct relationship between antioxidant status and Hb levels. Non enzymatic antioxidants included vitamin A,C and E. We also found a significant improvement (p <0.05) of these vitamins when compared with their initial values and the control group. Our study shows improvement of antioxidant status of anemic patients with 12 week supplementation of Beta vulgaris.</abstract><cop>Pakistan</cop><pmid>39348645</pmid><doi>10.36721/PJPS.2024.37.4.REG.803-808.1</doi></addata></record> |
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| subjects | Adult Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - diet therapy Anemia, Iron-Deficiency - drug therapy Antioxidants - pharmacology Beta vulgaris - chemistry Dietary Supplements Female Glutathione Peroxidase - metabolism Hemoglobins - metabolism Humans Male Middle Aged Oxidative Stress - drug effects Superoxide Dismutase - blood Superoxide Dismutase - metabolism Treatment Outcome Young Adult |
| title | Effects of beetroot (Beta vulgaris) supplements on selective enzymatic and non-enzymatic antioxidants in iron deficiency anemia |
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