mTOR activity paces human blastocyst stage developmental progression

Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway. It is unknown whether this ability is conserved in mammal...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2024-11, Vol.187 (23), p.6566-6583.e22
Hauptverfasser:	Iyer, Dhanur P., Khoei, Heidar Heidari, van der Weijden, Vera A., Kagawa, Harunobu, Pradhan, Saurabh J., Novatchkova, Maria, McCarthy, Afshan, Rayon, Teresa, Simon, Claire S., Dunkel, Ilona, Wamaitha, Sissy E., Elder, Kay, Snell, Phil, Christie, Leila, Schulz, Edda G., Niakan, Kathy K., Rivron, Nicolas, Bulut-Karslioğlu, Aydan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - cytology Blastocyst - metabolism blastoid Cell Proliferation development diapause dormancy Embryonic Development Endometrium - cytology Endometrium - metabolism Female human Humans Mice mTOR pluripotent stem cells Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!