Seasonal and genetic effects on lipid profiles of juvenile Atlantic salmon
Seasonality can influence many physiological traits requiring optimal energetic capacity for life-history stage transitions. In Atlantic salmon, high-energy status is essential for the initiation of maturation. Earlier studies have linked a genomic region encoding vgll3 to maturation age, potentiall...
Gespeichert in:
| Veröffentlicht in: | Biochimica et biophysica acta. Molecular and cell biology of lipids 2025-01, Vol.1870 (1), p.159565, Article 159565 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 159565 |
| container_title | Biochimica et biophysica acta. Molecular and cell biology of lipids |
| container_volume | 1870 |
| creator | House, Andrew H. Debes, Paul V. Holopainen, Minna Käkelä, Reijo Donner, Iikki Frapin, Morgane Ahi, Ehsan Pashay Kurko, Johanna Ruhanen, Hanna Primmer, Craig R. |
| description | Seasonality can influence many physiological traits requiring optimal energetic capacity for life-history stage transitions. In Atlantic salmon, high-energy status is essential for the initiation of maturation. Earlier studies have linked a genomic region encoding vgll3 to maturation age, potentially mediated via body condition. Vgll3 has also been shown to act as an inhibitor of adipogenesis in mice. Here we investigate the influence of season and vgll3 genotypes associating with early (EE) and late (LL) maturation on lipid profiles in the muscle and liver of juvenile Atlantic salmon. We reared Atlantic salmon for two years from fertilization and sampled muscle and liver during the spring and autumn of the second year (at which time some males were sexually mature). We found no seasonal or genotype effect in the muscle lipid profiles of immature males or females. However, in the liver we detected a triacylglycerol enrichment and a genotype specific direction of change in membrane lipids, phosphatidylcholine and phosphatidylethanolamine, from spring to autumn. Specifically, from spring to autumn membrane lipid concentrations increased in vgll3*EE individuals but decreased in vgll3*LL individuals. This could be explained by 1) a seasonally more stable capacity of endoplasmic reticulum (ER) functions in vgll3*EE individuals compared to vgll3*LL individuals or 2) vgll3*LL individuals storing larger lipid droplets from spring to autumn in the liver compared to vgll3*EE individuals at the expense of ER capacity. This genotype specific seasonal direction of change in membrane lipid concentrations provides more indirect evidence of a potential mechanism linking vgll3 with lipid metabolism and storage.
•Seasonal lipid species profile separation in muscle and liver in juvenile Atlantic salmon•Genotype specific direction of change of membrane lipids from spring to autumn•Indirect evidence that a mechanism linking vgll3 with lipid metabolism and storage exists. |
| doi_str_mv | 10.1016/j.bbalip.2024.159565 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3110729751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S138819812400115X</els_id><sourcerecordid>3110729751</sourcerecordid><originalsourceid>FETCH-LOGICAL-c287t-365357d36a7643d5fb31f59dd56dc97e588c209b92c9a8489cc5fa9dd78833ef3</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMojo6-gUiXblqbprlthGHwyoALdR3S5ERSehmbdsC3N0NHl65y-875Tz6ErnCe4Ryz2zqrKt34bVbkRZlhKimjR-gMCy7TgmFxHPdEiBRLgRfoPIQ6zzElhJ6iBZGEFIzxM_TyBjr0nW4S3dnkEzoYvUnAOTBjSPouiQneJtuhd76BeOOSetpBFw_Jamx0t8eDbtq-u0AnTjcBLg_rEn083L-vn9LN6-PzerVJTSH4mBJGCeWWMM1ZSSx1FcGOSmsps0ZyoEKYIpeVLIzUohTSGOp0fOdCEAKOLNHN3DcO9TVBGFXrg4EmDgP9FBTBOOeF5BRHtJxRM_QhDODUdvCtHr4VztXeoqrVbFHtLarZYiy7PiRMVQv2r-hXWwTuZgDiP3ceBhWMh86A9UMUp2zv_0_4AWldhJ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3110729751</pqid></control><display><type>article</type><title>Seasonal and genetic effects on lipid profiles of juvenile Atlantic salmon</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>House, Andrew H. ; Debes, Paul V. ; Holopainen, Minna ; Käkelä, Reijo ; Donner, Iikki ; Frapin, Morgane ; Ahi, Ehsan Pashay ; Kurko, Johanna ; Ruhanen, Hanna ; Primmer, Craig R.</creator><creatorcontrib>House, Andrew H. ; Debes, Paul V. ; Holopainen, Minna ; Käkelä, Reijo ; Donner, Iikki ; Frapin, Morgane ; Ahi, Ehsan Pashay ; Kurko, Johanna ; Ruhanen, Hanna ; Primmer, Craig R.</creatorcontrib><description>Seasonality can influence many physiological traits requiring optimal energetic capacity for life-history stage transitions. In Atlantic salmon, high-energy status is essential for the initiation of maturation. Earlier studies have linked a genomic region encoding vgll3 to maturation age, potentially mediated via body condition. Vgll3 has also been shown to act as an inhibitor of adipogenesis in mice. Here we investigate the influence of season and vgll3 genotypes associating with early (EE) and late (LL) maturation on lipid profiles in the muscle and liver of juvenile Atlantic salmon. We reared Atlantic salmon for two years from fertilization and sampled muscle and liver during the spring and autumn of the second year (at which time some males were sexually mature). We found no seasonal or genotype effect in the muscle lipid profiles of immature males or females. However, in the liver we detected a triacylglycerol enrichment and a genotype specific direction of change in membrane lipids, phosphatidylcholine and phosphatidylethanolamine, from spring to autumn. Specifically, from spring to autumn membrane lipid concentrations increased in vgll3*EE individuals but decreased in vgll3*LL individuals. This could be explained by 1) a seasonally more stable capacity of endoplasmic reticulum (ER) functions in vgll3*EE individuals compared to vgll3*LL individuals or 2) vgll3*LL individuals storing larger lipid droplets from spring to autumn in the liver compared to vgll3*EE individuals at the expense of ER capacity. This genotype specific seasonal direction of change in membrane lipid concentrations provides more indirect evidence of a potential mechanism linking vgll3 with lipid metabolism and storage.
•Seasonal lipid species profile separation in muscle and liver in juvenile Atlantic salmon•Genotype specific direction of change of membrane lipids from spring to autumn•Indirect evidence that a mechanism linking vgll3 with lipid metabolism and storage exists.</description><identifier>ISSN: 1388-1981</identifier><identifier>ISSN: 1879-2618</identifier><identifier>EISSN: 1879-2618</identifier><identifier>DOI: 10.1016/j.bbalip.2024.159565</identifier><identifier>PMID: 39332667</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Atlantic salmon ; Female ; Fish Proteins - genetics ; Fish Proteins - metabolism ; Genotype ; Life-history variation ; Lipid droplet ; Lipid Metabolism - genetics ; Lipidomics ; Lipids - genetics ; Liver - metabolism ; Male ; Membrane lipids ; Muscles - metabolism ; Salmo salar - genetics ; Salmo salar - growth & development ; Salmo salar - metabolism ; Seasonal metabolism ; Seasonality ; Seasons ; Triglycerides - genetics ; Triglycerides - metabolism</subject><ispartof>Biochimica et biophysica acta. Molecular and cell biology of lipids, 2025-01, Vol.1870 (1), p.159565, Article 159565</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c287t-365357d36a7643d5fb31f59dd56dc97e588c209b92c9a8489cc5fa9dd78833ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbalip.2024.159565$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39332667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>House, Andrew H.</creatorcontrib><creatorcontrib>Debes, Paul V.</creatorcontrib><creatorcontrib>Holopainen, Minna</creatorcontrib><creatorcontrib>Käkelä, Reijo</creatorcontrib><creatorcontrib>Donner, Iikki</creatorcontrib><creatorcontrib>Frapin, Morgane</creatorcontrib><creatorcontrib>Ahi, Ehsan Pashay</creatorcontrib><creatorcontrib>Kurko, Johanna</creatorcontrib><creatorcontrib>Ruhanen, Hanna</creatorcontrib><creatorcontrib>Primmer, Craig R.</creatorcontrib><title>Seasonal and genetic effects on lipid profiles of juvenile Atlantic salmon</title><title>Biochimica et biophysica acta. Molecular and cell biology of lipids</title><addtitle>Biochim Biophys Acta Mol Cell Biol Lipids</addtitle><description>Seasonality can influence many physiological traits requiring optimal energetic capacity for life-history stage transitions. In Atlantic salmon, high-energy status is essential for the initiation of maturation. Earlier studies have linked a genomic region encoding vgll3 to maturation age, potentially mediated via body condition. Vgll3 has also been shown to act as an inhibitor of adipogenesis in mice. Here we investigate the influence of season and vgll3 genotypes associating with early (EE) and late (LL) maturation on lipid profiles in the muscle and liver of juvenile Atlantic salmon. We reared Atlantic salmon for two years from fertilization and sampled muscle and liver during the spring and autumn of the second year (at which time some males were sexually mature). We found no seasonal or genotype effect in the muscle lipid profiles of immature males or females. However, in the liver we detected a triacylglycerol enrichment and a genotype specific direction of change in membrane lipids, phosphatidylcholine and phosphatidylethanolamine, from spring to autumn. Specifically, from spring to autumn membrane lipid concentrations increased in vgll3*EE individuals but decreased in vgll3*LL individuals. This could be explained by 1) a seasonally more stable capacity of endoplasmic reticulum (ER) functions in vgll3*EE individuals compared to vgll3*LL individuals or 2) vgll3*LL individuals storing larger lipid droplets from spring to autumn in the liver compared to vgll3*EE individuals at the expense of ER capacity. This genotype specific seasonal direction of change in membrane lipid concentrations provides more indirect evidence of a potential mechanism linking vgll3 with lipid metabolism and storage.
•Seasonal lipid species profile separation in muscle and liver in juvenile Atlantic salmon•Genotype specific direction of change of membrane lipids from spring to autumn•Indirect evidence that a mechanism linking vgll3 with lipid metabolism and storage exists.</description><subject>Animals</subject><subject>Atlantic salmon</subject><subject>Female</subject><subject>Fish Proteins - genetics</subject><subject>Fish Proteins - metabolism</subject><subject>Genotype</subject><subject>Life-history variation</subject><subject>Lipid droplet</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipidomics</subject><subject>Lipids - genetics</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Membrane lipids</subject><subject>Muscles - metabolism</subject><subject>Salmo salar - genetics</subject><subject>Salmo salar - growth & development</subject><subject>Salmo salar - metabolism</subject><subject>Seasonal metabolism</subject><subject>Seasonality</subject><subject>Seasons</subject><subject>Triglycerides - genetics</subject><subject>Triglycerides - metabolism</subject><issn>1388-1981</issn><issn>1879-2618</issn><issn>1879-2618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMojo6-gUiXblqbprlthGHwyoALdR3S5ERSehmbdsC3N0NHl65y-875Tz6ErnCe4Ryz2zqrKt34bVbkRZlhKimjR-gMCy7TgmFxHPdEiBRLgRfoPIQ6zzElhJ6iBZGEFIzxM_TyBjr0nW4S3dnkEzoYvUnAOTBjSPouiQneJtuhd76BeOOSetpBFw_Jamx0t8eDbtq-u0AnTjcBLg_rEn083L-vn9LN6-PzerVJTSH4mBJGCeWWMM1ZSSx1FcGOSmsps0ZyoEKYIpeVLIzUohTSGOp0fOdCEAKOLNHN3DcO9TVBGFXrg4EmDgP9FBTBOOeF5BRHtJxRM_QhDODUdvCtHr4VztXeoqrVbFHtLarZYiy7PiRMVQv2r-hXWwTuZgDiP3ceBhWMh86A9UMUp2zv_0_4AWldhJ4</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>House, Andrew H.</creator><creator>Debes, Paul V.</creator><creator>Holopainen, Minna</creator><creator>Käkelä, Reijo</creator><creator>Donner, Iikki</creator><creator>Frapin, Morgane</creator><creator>Ahi, Ehsan Pashay</creator><creator>Kurko, Johanna</creator><creator>Ruhanen, Hanna</creator><creator>Primmer, Craig R.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202501</creationdate><title>Seasonal and genetic effects on lipid profiles of juvenile Atlantic salmon</title><author>House, Andrew H. ; Debes, Paul V. ; Holopainen, Minna ; Käkelä, Reijo ; Donner, Iikki ; Frapin, Morgane ; Ahi, Ehsan Pashay ; Kurko, Johanna ; Ruhanen, Hanna ; Primmer, Craig R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c287t-365357d36a7643d5fb31f59dd56dc97e588c209b92c9a8489cc5fa9dd78833ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Animals</topic><topic>Atlantic salmon</topic><topic>Female</topic><topic>Fish Proteins - genetics</topic><topic>Fish Proteins - metabolism</topic><topic>Genotype</topic><topic>Life-history variation</topic><topic>Lipid droplet</topic><topic>Lipid Metabolism - genetics</topic><topic>Lipidomics</topic><topic>Lipids - genetics</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Membrane lipids</topic><topic>Muscles - metabolism</topic><topic>Salmo salar - genetics</topic><topic>Salmo salar - growth & development</topic><topic>Salmo salar - metabolism</topic><topic>Seasonal metabolism</topic><topic>Seasonality</topic><topic>Seasons</topic><topic>Triglycerides - genetics</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>House, Andrew H.</creatorcontrib><creatorcontrib>Debes, Paul V.</creatorcontrib><creatorcontrib>Holopainen, Minna</creatorcontrib><creatorcontrib>Käkelä, Reijo</creatorcontrib><creatorcontrib>Donner, Iikki</creatorcontrib><creatorcontrib>Frapin, Morgane</creatorcontrib><creatorcontrib>Ahi, Ehsan Pashay</creatorcontrib><creatorcontrib>Kurko, Johanna</creatorcontrib><creatorcontrib>Ruhanen, Hanna</creatorcontrib><creatorcontrib>Primmer, Craig R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimica et biophysica acta. Molecular and cell biology of lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>House, Andrew H.</au><au>Debes, Paul V.</au><au>Holopainen, Minna</au><au>Käkelä, Reijo</au><au>Donner, Iikki</au><au>Frapin, Morgane</au><au>Ahi, Ehsan Pashay</au><au>Kurko, Johanna</au><au>Ruhanen, Hanna</au><au>Primmer, Craig R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seasonal and genetic effects on lipid profiles of juvenile Atlantic salmon</atitle><jtitle>Biochimica et biophysica acta. Molecular and cell biology of lipids</jtitle><addtitle>Biochim Biophys Acta Mol Cell Biol Lipids</addtitle><date>2025-01</date><risdate>2025</risdate><volume>1870</volume><issue>1</issue><spage>159565</spage><pages>159565-</pages><artnum>159565</artnum><issn>1388-1981</issn><issn>1879-2618</issn><eissn>1879-2618</eissn><abstract>Seasonality can influence many physiological traits requiring optimal energetic capacity for life-history stage transitions. In Atlantic salmon, high-energy status is essential for the initiation of maturation. Earlier studies have linked a genomic region encoding vgll3 to maturation age, potentially mediated via body condition. Vgll3 has also been shown to act as an inhibitor of adipogenesis in mice. Here we investigate the influence of season and vgll3 genotypes associating with early (EE) and late (LL) maturation on lipid profiles in the muscle and liver of juvenile Atlantic salmon. We reared Atlantic salmon for two years from fertilization and sampled muscle and liver during the spring and autumn of the second year (at which time some males were sexually mature). We found no seasonal or genotype effect in the muscle lipid profiles of immature males or females. However, in the liver we detected a triacylglycerol enrichment and a genotype specific direction of change in membrane lipids, phosphatidylcholine and phosphatidylethanolamine, from spring to autumn. Specifically, from spring to autumn membrane lipid concentrations increased in vgll3*EE individuals but decreased in vgll3*LL individuals. This could be explained by 1) a seasonally more stable capacity of endoplasmic reticulum (ER) functions in vgll3*EE individuals compared to vgll3*LL individuals or 2) vgll3*LL individuals storing larger lipid droplets from spring to autumn in the liver compared to vgll3*EE individuals at the expense of ER capacity. This genotype specific seasonal direction of change in membrane lipid concentrations provides more indirect evidence of a potential mechanism linking vgll3 with lipid metabolism and storage.
•Seasonal lipid species profile separation in muscle and liver in juvenile Atlantic salmon•Genotype specific direction of change of membrane lipids from spring to autumn•Indirect evidence that a mechanism linking vgll3 with lipid metabolism and storage exists.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39332667</pmid><doi>10.1016/j.bbalip.2024.159565</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-1981 |
| ispartof | Biochimica et biophysica acta. Molecular and cell biology of lipids, 2025-01, Vol.1870 (1), p.159565, Article 159565 |
| issn | 1388-1981 1879-2618 1879-2618 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3110729751 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Atlantic salmon Female Fish Proteins - genetics Fish Proteins - metabolism Genotype Life-history variation Lipid droplet Lipid Metabolism - genetics Lipidomics Lipids - genetics Liver - metabolism Male Membrane lipids Muscles - metabolism Salmo salar - genetics Salmo salar - growth & development Salmo salar - metabolism Seasonal metabolism Seasonality Seasons Triglycerides - genetics Triglycerides - metabolism |
| title | Seasonal and genetic effects on lipid profiles of juvenile Atlantic salmon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T20%3A11%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Seasonal%20and%20genetic%20effects%20on%20lipid%20profiles%20of%20juvenile%20Atlantic%20salmon&rft.jtitle=Biochimica%20et%20biophysica%20acta.%20Molecular%20and%20cell%20biology%20of%20lipids&rft.au=House,%20Andrew%20H.&rft.date=2025-01&rft.volume=1870&rft.issue=1&rft.spage=159565&rft.pages=159565-&rft.artnum=159565&rft.issn=1388-1981&rft.eissn=1879-2618&rft_id=info:doi/10.1016/j.bbalip.2024.159565&rft_dat=%3Cproquest_cross%3E3110729751%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3110729751&rft_id=info:pmid/39332667&rft_els_id=S138819812400115X&rfr_iscdi=true |