TGN-020 ameliorates motor dysfunction post-spinal cord injury via enhancing astrocyte autophagy and mitigating inflammation by activating AQP4/PPAR-γ/mTOR pathway

Spinal Cord Injury (SCI) is a severe condition that often leads to substantial neurological impairments. This study aimed to explore the role of Aquaporin-4 (AQP4) in regulating astrocyte autophagy and neuroinflammation post-SCI, as well as to evaluate the therapeutic potential of AQP4 inhibition us...

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Veröffentlicht in:	Experimental neurology 2024-12, Vol.382, p.114975, Article 114975
Hauptverfasser:	Kong, Jundong, Zhang, Qiangqiang, Zheng, Haohong, Tang, Diandong, Fang, Li, An, Shuaihao, Li, Jian, Fan, Zhongkai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaporin 4 - antagonists & inhibitors Aquaporin 4 - metabolism Aquaporin-4 Astrocytes - drug effects Astrocytes - metabolism Autophagy Autophagy - drug effects Inflammation Inflammation - drug therapy Inflammation - metabolism Male Neuroinflammatory Diseases - drug therapy Neuroinflammatory Diseases - metabolism Niacinamide - analogs & derivatives PPAR gamma - metabolism PPAR-γ/mTOR Rats Rats, Sprague-Dawley Signal Transduction - drug effects Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal cord injury Thiadiazoles - pharmacology Thiadiazoles - therapeutic use TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
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